Expression of genes of KCNQ potassium channels in cultured hippocampal inhibitory interneurons, and participation of these channels in the regulation of GABA-ergic transmission
Abstract:The expression and functioning of KCNQ potassium channels in the membranes of inhibitory interneurons of hippocampal culture and the involvement of these channels in the regulation of GABA-ergic synaptic transmission were investigated using a reverse transcription (RT) and polymerase chain reaction (PCR) for the single-cell technique (single-cell RT-PCR) and a patch-clamp technique in the "whole-cell" configuration. Expression of the genes of KCNQ2 and KCNQ3 α-subunits was revealed in all the GABA-ergic intern… Show more
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