Expression of functionally distinct ecto‐5′‐nucleotidase/CD73 glycovariants in reactive astrocytes in experimental autoimmune encephalomyelitis and neuroinflammatory conditions in vitro
Marija Adzic Bukvic,
Danijela Laketa,
Milorad Dragic
et al.
Abstract:Ecto‐5′‐nucleotidase/CD73 (eN/CD73) is a membrane‐bound enzyme involved in extracellular production of adenosine and a cell adhesion molecule involved in cell–cell interactions. In neuroinflammatory conditions such as experimental autoimmune encephalomyelitis (EAE), reactive astrocytes occupying active demyelination areas significantly upregulate eN/CD73 and express additional eN/CD73 variants. The present study investigated whether the different eN/CD73 variants represent distinct glycoforms and the functiona… Show more
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