Expression of functional major histocompatility complex class II molecules on HMC-1 human mast cells

Dimitriadou, Violetta; Mécheri, Salaheddine; Koutsilieris, Michael; Fraser, William D.; Al-Daccak, Reem; Mourad, Walid

doi:10.1002/jlb.64.6.791

Cited by 43 publications

(27 citation statements)

References 68 publications

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“…It has been reported that MCs can process bacterial Ags through a phagocytic route for MHC class I presentation to T cells (11,12) and that human MCs can induce MHC class II-dependent activation of CD4 ϩ T cell hybridomas through superantigen presentation (13,14). We confirmed that MHC class II expression on human MCs was up-regulated in IFN-␥ treatment or Fc⑀RI activation (data not shown).…”

Section: Discussionsupporting

confidence: 81%

“…Recent studies indicate that MCs can process bacterial Ags through a phagocytic route for MHC class I presentation to T cells (11,12) and that MCs can induce MHC class II-dependent activation of CD4-positive (CD4 ϩ ) T cell hybridomas through superantigen presentation (13,14). A subsequent study has shown that signaling generated by Fc⑀RI provides MCs with IgE-mediated enhanced Ag presentation to T cells (15).…”

Section: Ast Cells (Mcs)mentioning

confidence: 99%

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T Cell Proliferation by Direct Cross-Talk between OX40 Ligand on Human Mast Cells and OX40 on Human T Cells: Comparison of Gene Expression Profiles between Human Tonsillar and Lung-Cultured Mast Cells

Kashiwakura

Yokoi

Saito

et al. 2004

The Journal of Immunology

150

120

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Mast cells (MCs) are the primary effector cells in allergic reactions and have also been found to activate T cells and to reside in close physical proximity to T cells. However, the molecular mechanisms involved in the MC-T cell interaction remain unclear. We hypothesized that human tonsillar MCs, which locate in the interfollicular areas, might interact with T cells. Thus, we first established a culture system of human tonsillar MCs and then compared gene expression profiles of tonsillar MCs with that of lung MCs before and after aggregation of FcεRI by using high-density oligonucleotide probe arrays. Here we show that resting tonsillar MCs, when compared with lung MCs, revealed significantly higher expression levels for CC chemokines (CCL3 and 4), which recruit T cells, and for TNFR superfamilies (OX40 ligand and 4-1BB ligand), which induce proliferation of T cells. After aggregation of FcεRI, not only tonsillar MCs but also lung MCs up-regulated the expression of these molecules. We confirmed that T cell proliferation is induced in direct cross-talk by the MC surface molecule OX40 ligand. These results suggest that human MCs may play important roles in adaptive immunity through the T cell responses.

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Section: Discussionsupporting

confidence: 81%

Section: Ast Cells (Mcs)mentioning

confidence: 99%

T Cell Proliferation by Direct Cross-Talk between OX40 Ligand on Human Mast Cells and OX40 on Human T Cells: Comparison of Gene Expression Profiles between Human Tonsillar and Lung-Cultured Mast Cells

Kashiwakura

Yokoi

Saito

et al. 2004

The Journal of Immunology

150

120

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“…98 They present antigens to naive T cells in an MHC-restricted manner. 99,100 Mast cells stimulate the migration of antigen-presenting cells to nodes through the release of IL-1, -3, and -6 and TNF. 101 They also influence T cell differentiation: IL-4 and histamine direct Th 2 responses 102 as well as modulate the differentiation of Th17 ϩ CD4 cells.…”

Section: Role Of Mast Cells In Inflammatory and Autoimmune Kidney Dismentioning

confidence: 99%

Role of Mast Cells in Progressive Renal Diseases

Holdsworth¹,

Summers²

2008

Journal of the American Society of Nephrology

116

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“…One possible additional mechanism is that the binding of HD8 Abs to HLA-DR on mast cells activates them; indeed, it has been shown that such binding induces ultrastructural mast cell changes that suggest they are induced to secrete granules (28). However, this possibility is less likely because the Fab of the HD8 Ab did not induce infusion reactions in the rat model.…”

Section: Discussionmentioning

confidence: 99%

Complement Activation Plays a Key Role in Antibody-Induced Infusion Toxicity in Monkeys and Rats

Tawara

Hasegawa

Sugiura

et al. 2008

The Journal of Immunology

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Infusion reactions are a major side effect of the administration of therapeutic Abs and are the result of a complex immune reaction. In this study, we report that substitutions of Fc amino acids in the anti-HLA-DR Ab HD8 reduce its ability to induce infusion reactions in rats and monkeys. We first showed that i.v. administration of IgG1- and IgG2-subclass HD8 Abs induces severe infusion reactions in monkeys. These Abs express strong complement-dependent cytotoxicity (CDC), and in vivo depletion of complement in rats by pretreatment with cobra venom factor abrogated the lethal infusion reactions generated by HD8-IgG1. Thus, the infusion reactions appear to be largely driven by the complement system. To reduce the CDC function of HD8-IgG1, its Fc region was modified by two amino acid substitutions at Pro331Ser and Lys322Ala. The modified Ab was incapable of expressing CDC in vitro and did not induce severe infusion reactions in rats and monkeys, even at extremely high doses. The modified Ab retained its Ab-dependent cellular cytotoxicity function as well as its antitumor activity in a tumor-bearing mouse model. In summary, complement appears to drive infusion reactions, and modifications that eliminate the CDC activity of an Ab also reduce its ability to induce infusion reactions.

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Expression of functional major histocompatility complex class II molecules on HMC-1 human mast cells

Cited by 43 publications

References 68 publications

T Cell Proliferation by Direct Cross-Talk between OX40 Ligand on Human Mast Cells and OX40 on Human T Cells: Comparison of Gene Expression Profiles between Human Tonsillar and Lung-Cultured Mast Cells

T Cell Proliferation by Direct Cross-Talk between OX40 Ligand on Human Mast Cells and OX40 on Human T Cells: Comparison of Gene Expression Profiles between Human Tonsillar and Lung-Cultured Mast Cells

Role of Mast Cells in Progressive Renal Diseases

Complement Activation Plays a Key Role in Antibody-Induced Infusion Toxicity in Monkeys and Rats

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