Expression of Follicle-Stimulating Hormone Receptor in Tumor Blood Vessels

Abstract

Environmental disorders associated with vitamin D deficiency include musculoskeletal disorders (childhood rickets, osteomalacia, and fractures), and may include extraskeletal disorders (diabetes, cardiovascular disease, risk of falls, and cancer). There is high interindividual variability in the occurrence of both musculoskeletal and extraskeletal disorders. Previous twin and family studies suggested that genetic factors play a significant role in this variability. Little data exist on the possible effects of common genetic variation on vitamin D status; the available studies have been small and only small numbers of variants were examined.The SUNLIGHT consortium (study of underlying genetic determinants of vitamin D and highly related traits) was a multicenter genome-wide association study designed to identify common genetic variants that affect vitamin D concentrations and increase the risk of vitamin D insufficiency. Concentrations of vitamin D were determined in 33,996 individuals of European descent from 15 epidemiologic cohorts. Of these cohorts, 5 were designated as discovery cohorts (n ϭ 16,125), 5 as in-silico replication cohorts (n ϭ 9367), and 5 as de novo replication cohorts (n ϭ 8504). Genome-wide analyses were conducted in all cohorts. Methods used to measure 25-hydroxyvitamin D concentrations varied between cohorts and included radioimmunoassay, chemiluminescent assay, enzyme-linked immunosorbent assay, or mass spectrometry. Concentrations lower than 75 nmol/L or 50 nmol/L were the defined threshold for vitamin D insufficiency. Combined effect estimates from the logistic regression analysis across cohorts were calculated by meta-analysis using a weighted Z-score-based approach. A genotype score was constructed by taking a weighted average of the confirmed variants. GYNECOLOGYVolume 66, Number 2 OBSTETRICAL AND GYNECOLOGICAL SURVEY ABSTRACT A number of epidemiological studies have reported an association between plasma levels of the proinflammatory cytokines, C-reactive protein (CRP), interleukin-6 (IL-6), and the risk of cardiovascular disease and all-cause mortality. Plasma levels of these cytokines also appear to be associated with obesity and insulin resistance; both are elevated in patients with type 2 diabetes and insulin resistance. Approximately 15% to 30% of factors associated with exceptional longevity are genetic. Many of the environmental factors associated with exceptional longevity are potentially modifiable. The association between circulating CRP and IL-6 levels with type 2 diabetes and cardiovascular disease, diseases generally associated with decreased survival, suggests that elevations in the plasma levels of these inflamma- Cardiovascular Endocrinology 93ABSTRACT Short-term risks to children conceived by in vitro fertilization (IVF) include adverse perinatal outcomes and birth defects. Little data are available on long-term risks in IVF children, especially for subtle measures of cognitive development. The few studies that have investigated cognitive development in these children...

The effect of toxoplasmosis on the level of some sex hormones in males blood donors in Baghdad

“…The quantitative production of spermatozoa generally requires the presence of FSH, LH and testosterone (Anderson et al 1997). The role of FSH for the initiation of spermatogenesis is more important for female than for male fertility (Radu et al 2010). …”

Immunohistochemical detection of follicle stimulating hormone receptor (FSHR) in neuroendocrine tumours

“…However, their incidence was also recently revealed in numerous non-gonadal tumours. Radu et al [2] found the expression of FSHR in endothelia of intra-and peritumoral blood vessels in a large series of non-gonadal cancers (prostate, breast, colon, pancreas, bladder, kidney, lung, liver and stomach). The quoted authors claim that FSHR incidence is specific for tumoral and peritumoral blood vessels since they found them neither in endothelia of non-tumoral vessels nor in tumoral cells.…”

Revisiting the Role of Antiandrogen Strategies in Ovarian Cancer

“…The proposed mechanism of GnRH analogs (goserelin, triptorelin) in epithelial ovarian cancer is thought to be desensitization or downregulation of GnRH receptors in the pituitary, resulting in a decline in gonadotropin secretion and subsequent reduction in gonadal steroids including androgens. giogenesis, raising the possibility that GnRH analogs may impact ovarian cancer growth by additional mechanisms [64]. Combining the data from all 12 trials, a total of 21 (5.7%) patients achieved an objective response and 77 patients (21%) had stable disease (SD).…”