Expression of female sex hormone receptors in human middle-ear cholesteatomas

Raynov, Alexander M.; Choung, Yun‐Hoon; Moon, Sung-Kyun; Park, Keehyun

doi:10.1258/002221505775010878

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…progesterone receptor and estrogen receptor) differed between male and female patients with cholesteatoma, suggesting that estrogen has an effect on keratinocyte proliferation and differentiation in cholesteatoma. 26 In contrast to the study by Raynov et al, we examined manifestations of bone destruction in chronic otitis media. We focused on ER-α, which is assumed to have a close relationship with bone destruction in chronic otitis media, in contrast to the role of the progesterone receptor.…”

Section: Discussionmentioning

confidence: 99%

Bone destruction in chronic otitis media is not mediated by the RANKL pathway or estrogen receptor-alpha

Heo,

Noh,

Hur

et al. 2023

Science Progress

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Background Chronic otitis media with or without cholesteatoma progresses with various degrees of bone resorption and remodeling. Estrogen mediates osteoprotective effects through the receptor activator of NF-κB ligand (RANKL) pathway, which is mainly mediated by estrogen receptor-alpha (ER-α). Objectives The present study investigated the expression patterns of receptor activator of NF-κB (RANK), osteoprotegerin (OPG), RANKL, and ER-α in pathological tissue from patients with chronic otitis media to determine the roles of those factors in osteolytic mechanisms underlying the pathogenesis of chronic otitis media. Methods Normal and pathological specimens from 18 patients with chronic otitis media were examined. Results There were no significant differences in RANK, OPG, RANKL, or ER-α mRNA expression between normal and pathological specimens of epithelial tissue. Conclusions Our findings suggested that RANK, OPG, RANKL, and ER-α are not associated with the bone destruction in chronic otitis media; other cytokines may directly activate the osteoclasts in chronic otitis media.

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Section: Discussionmentioning

confidence: 99%

Bone destruction in chronic otitis media is not mediated by the RANKL pathway or estrogen receptor-alpha

Heo,

Noh,

Hur

et al. 2023

Science Progress

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“…In the presence of sex hormone receptors in human middle ear cholesteatoma, stronger expression of progesterone receptor was found in samples from male patients, while stronger expression of estrogen receptor was found in samples from female patients. It suggests that female sex hormones may stimulate proliferation of middle ear cholesteatoma keratinocytes [67]. Estrogen levels between females and males in different ages may influence the function of the auditory systems, and the details of the mechanism should be studied in the future.…”

Section: Gender Differences In Auditory Functionmentioning

confidence: 99%

Sex Hormones and Inner Ear

He¹

2018

Sex Hormones in Neurodegenerative Processes and Diseases

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There are increasing evidence of interactions between sex hormones and the structure and function of inner ear, especially in hearing impairment and balance disorders. In this chapter, we will discuss the mechanism of sex hormones on the inner ear, describe both clinical and basic research that has led us to our current understanding, and conclude with future perspectives on avenues of investigation that may lead to innovative treatments on the hearing loss, tinnitus, and dizziness resulted from the changes in estrogen and progesterone levels. The presence of estrogen receptors α and β has earlier been shown in the inner ear of mice. Expression of estrogen receptors (ER) correlates with the protection of auditory function. Estrogen may have certain protective effects on the hearing. Evidence for the treatment of sex hormone-induced symptoms is principally restricted to case reports and retrospective studies. Recognition and understanding of sex hormone-related inner ear problems will allow otologists to notice and manage these patients. Also, basic studies on the mechanism of how sex hormones act on inner ear provide the way to further prevent and treat on hearing impairment and balance disorders. High-quality evidence for their management is limited, with further research required.

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“…Although cholesteatoma has been recognized for more than three centuries [20], the nature of this disorder has yet not been fully determined, particularly the factors regulating its progression [28]. Some studies revealed that sex predilection for cholesteatoma might be dependent on the expression of female sex hormone receptors in the middle ear that act as an auditory protectant [43]. It has also been noted that various expression of genes may control pathogenesis of cholesteatomas [3,29,40].…”

Section: Introductionmentioning

confidence: 99%