Expression of excision repair cross-complementation group 1 protein predicts poor outcome in patients with small cell lung cancer

High expression of excision repair cross-complementation group1 protein predicts poor outcome in patients with nasopharyngeal cancer

“…The correlation between the expression of ERCC1 and resistance to platinum-based chemotherapy or prognosis has been reported in various malignancies, such as non-small and small cell lung, esophageal, gastric, colorectal, and ovarian cancers. 11,16,[26][27][28] In head and neck squamous cell carcinoma, high expression of ERCC1 was associated with poor survival in patients with locally advanced disease treated by CRT. 29,30 The poor outcome for NPC patients with high expression of ERCC1 most likely results from a resistance to cisplatin, which is an integral component of CRT for locally advanced NPC.…”

Bax Predicts Outcome in Gastric Cancer Patients Treated with 5-fluorouracil, Leucovorin, and Oxaliplatin Palliative Chemotherapy

“…Bax and excision repair cross-complementation group 1 (ERCC1), one of the nucleotide excision repair system's key enzymes, have been investigated as important candidates for predictors of resistance to chemotherapy in many malignancies [18][19][20]. In terms of resistance to 5-FU, thymidylate synthase (TS), which is a critical target of 5-FU, has been widely investigated.…”

In vitro modulation of Bcl-2 levels in small cell lung cancer cells: effects on cell viability

“…Nevertheless, despite controversial data, existing evidence about the specific role of Bcl-2 in SCLC is consistent with the results obtained in the present study. It has been demonstrated that, regardless of the frequently observed Bcl-2 overexpression in SCLC cell lines (2) and tumors (3), there is no correlation between Bcl-2 expression and resistance to therapy and/or patient survival (26)(27)(28)(29)(30). In fact, Bcl-2 overexpression, mainly with nuclear localization, together with a high Bcl-2/Bax ratio, was correlated directly with an elevated spontaneous apoptosis index (31)(32)(33), and with the absence of metastasis in SCLC tumors (34).…”