Expression of estrogen receptors α and β in the corpus luteum and uterus from non‐pregnant and pregnant llamas

Powell, Susan A.; Smith, Bruce P.; Timm, Karen I.; Menino, Alfred R.

doi:10.1002/mrd.20684

Cited by 12 publications

(14 citation statements)

References 42 publications

(52 reference statements)

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“…Because all embryos migrate to the left horn, a greater expression of ER in the right horn to promote its contraction was expected but could not be demonstrated. This suggests that a more complex mechanism with differential expression of ER subtypes may be involved in embryo migration from the right to the left horn (Powell et al, 2007a). These findings were supported by recent work in our laboratory, which did not demonstrate a greater expression of ERα in the right uterine horn of pregnant alpacas (Figure 4 and 5) to promote its contraction (Campbell, 2015), as well as recent research performed in camels (Abdoon et al, 2017).…”

Section: Maternal Recognition Of Pregnancy In Camelidssupporting

confidence: 82%

See 1 more Smart Citation

Early Embryonic Development and Maternal Recognition of Pregnancy in Camelids: A Review

Campbell¹,

Ciccarelli²,

Tibary³

2017

SPERMOVA

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Section: Maternal Recognition Of Pregnancy In Camelidssupporting

confidence: 82%

“…The authors suggested that the presence of an embryo may be influencing this expression (Powell et al, 2007a). Endometrial expression of ERα and ERβ was not affected by uterine side or days post-mating.…”

Section: Maternal Recognition Of Pregnancy In Camelidsmentioning

confidence: 99%

Early Embryonic Development and Maternal Recognition of Pregnancy in Camelids: A Review

Campbell¹,

Ciccarelli²,

Tibary³

2017

SPERMOVA

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“…2001). Previous reports have shown an absence of ERβ RNAm during the follicular phase in llamas (Powell et al. 2007).…”

Section: Discussionmentioning

confidence: 74%

Endometrial Population of Oestrogen Receptors Alpha and Beta and Progesterone Receptors A and B During the Different Phases of the Follicular Wave of Llamas (Lama glama)

Bianchi

Sahlin

Meikle

et al. 2009

Reproduction in Domestic Animals

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The aim of this study was to characterize the distribution of oestrogen receptor (ER)α and ERβ as well as both progesterone receptors isoforms progesterone receptor (PR) A and PRB in the luminal and glandular epithelia and stroma of the endometrium during the different phases of the follicular wave in llamas. Six llamas were examined by transrectal ultrasonography, and a transcervical biopsy was obtained when a follicle at the growing, plateau and regressing phase was recorded. Blood samples were collected at the time of biopsy for hormone determinations. An immunohistochemical technique was used to study receptor populations. Total positive area was evaluated in the different cell types by Image Analysis. Mean diameter measurements of the largest follicle were 6.9, 8.5 and 5.1 mm (p < 0.001) and mean plasma oestradiol-17β concentrations were 27.9 ± 3.26; 30.0 ± 2.79 and 24.0 ± 1.78 pmol/l (p = 0.32) during the growing, plateau and regressing phases, respectively. Immunostaining of ERα was higher in the luminal epithelium during the plateau and regressing phases (p < 0.05) than during the growing phase. More positive cells to ERβ were observed in the glandular epithelium of the growing and plateau phases (p < 0.05) than during the regressing phase. A higher percentage of cells positive to PRB was recorded in the luminal and glandular epithelia during the plateau phase (p < 0.05), while the PRA immunostaining was similar among phases. In brief, this study showed an increased population of ERα and PRB in the luminal epithelium, and only of PRB in the glandular epithelium at the time when an ovulatory follicle is present. The physiological importance of these changes in llamas remains to be elucidated.

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“…E2 is well accepted to be a critical component of endometrial development and pregnancy in both animal and human models [13,15]. Some studies have shown that, in some women, E2 levels may drop during the luteal phase of an IVF cycle [14].…”

Section: Resultsmentioning

confidence: 99%

“…Animal and human studies have shown that estradiol (E2) serves a critical role in endometrial development compatible with successful pregnancy [13,14]. Additionally, data have shown that, in some women, E2 levels fall in the mid luteal phase of an IVF cycle [14].…”

Section: Introductionmentioning

confidence: 99%

The impact of luteal phase support on endometrial estrogen and progesterone receptor expression: a randomized control trial

Brezina

Vlahos²,

Lai

et al. 2012

Reprod Biol Endocrinol

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BackgroundTo assess the impact of luteal phase support on the expression of estrogen receptor (ER) alpha and progesterone receptors B (PR-B) on the endometrium of oocyte donors undergoing controlled ovarian hyperstimulation (COH).MethodsA prospective, randomized study was conducted in women undergoing controlled ovarian hyperstimulation for oocyte donation. Participants were randomized to receive no luteal support, vaginal progesterone alone, or vaginal progesterone plus orally administered 17 Beta estradiol. Endometrial biopsies were obtained at 4 time points in the luteal phase and evaluated by tissue microarray for expression of ER alpha and PR-B.ResultsOne-hundred and eight endometrial tissue samples were obtained from 12 patients. No differences were found in expression of ER alpha and PR-B among all the specimens with the exception of one sample value.ConclusionsThe administration of progesterone during the luteal phase of COH for oocyte donor cycles, either with or without estrogen, does not significantly affect the endometrial expression of ER alpha and PR.

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Expression of estrogen receptors α and β in the corpus luteum and uterus from non‐pregnant and pregnant llamas

Cited by 12 publications

References 42 publications

Early Embryonic Development and Maternal Recognition of Pregnancy in Camelids: A Review

Early Embryonic Development and Maternal Recognition of Pregnancy in Camelids: A Review

Endometrial Population of Oestrogen Receptors Alpha and Beta and Progesterone Receptors A and B During the Different Phases of the Follicular Wave of Llamas (Lama glama)

The impact of luteal phase support on endometrial estrogen and progesterone receptor expression: a randomized control trial

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