Expression of Eps8 correlates with poor survival in oral squamous cell carcinoma

Abstract

Eps8 is frequently expressed in OSCC. The aberrant expression of Eps8 closely correlated with poor survival in patients with OSCC.

Novel Oncoprotein EPS8: A New Target for Anticancer Therapy

“…Among them, EPS8 and EPS8L2 show a wide and overlapping expression and are both present in cerebellum, prostate, pancreas (duct epithelium), kidney, liver, lung and breast tissue [14,30]. Currently, abundant studies have elucidated elevated EPS8 expression in most human solid tumor types and hematologic malignancies (Table 1) [8], papillary thyroid carcinoma [9], pituitary tumor [10], pancreatic cancer [11] and mixed lineage leukemia (MLL) [12].…”

“…Not only has EPS8 been identified as a novel putative oncogene in breast cancer [31] and thyroid cancer [32], but it also has been reported to amplify EGFR signaling in promoting proliferation and progression of tumors, for example colon, pituitary and pancreatic cancers [7, 10,11]. Furthermore, increased EPS8 in cancer patients might also be an unfavorable prognostic biomarker for decreased overall survival in OSCC [8], MLL [12], cervical and ovarian cancers [6,33].…”

“…The EPS8/AKT/FOXM1 pathway Apart from the EPS8/Ras/ERK pathway above, EGF triggers the recruitment of PI3K to activated EGFR, leading to the formation of phosphatidylinositol (3,4,5)-triphosphate, Oral squamous cell carcinoma 186 (205) [8] Papillary thyroid carcinoma 8 (8) [9] Pituitary tumor 5.9-fold [10] Pancreatic cancer 4-fold [11] Mixed lineage leukemia High risk [12] 'x-fold' or 'high risk' means authors of the articles did not present a specific value of the number of tumors with elevated EPS8 levels. The author determined binary risk classification for event prediction by a threshold, with values above the threshold predicting 'high risk' [12].…”

“…EPS8 as a promising target for anticancer therapy EPS8 is overexpressed in many types of human solid tumors and hematologic malignancies (Table 1) [5][6][7][8][9][10][11][12]. Growing evidence implies that EPS8 expression in cancer cells may represent an essential prognostic biomarker for patient outcome.…”

“…Fazioli et al identified two proteins with molecular weights of 97 and 68 kDa recognized by the EPS8 antibody and referred to them as the two EPS8 isoforms (p97EPS8 and p68EPS8, respectively) [2], and these two isoforms of EPS8 have been identified as the substrates for several receptor tyrosine kinases [3]. EPS8 is universally expressed [4], and its overexpression is closely related to the formation of various types of human solid tumors and hematologic malignancies (Table 1) [5][6][7][8][9][10][11][12]. In addition, elevated EPS8 facilitates increased mitogenesis and malignant transformation in response to EGF [13].…”