Expression of epithelial growth factor receptor, tumor necrosis factor-α and nuclear factor κB in inflammatory bowel diseases

Abstract

Expression of epithelial growth factor receptor, tumor necrosis factor-α α and nuclear factor κ κB in inflammatory bowel diseases Ekspresja receptora dla naskórkowego czynnika wzrostu, czynnika martwicy nowotworów α i czynnika jądrowego κB w nieswoistych chorobach zapalnych jelit K Ke ey y w wo or rd ds s: : inflammatory bowel diseases, epithelial growth factor receptor, tumor necrosis factor-α, nuclear factor κB. S Sł ło ow wa a k kl lu uc cz zo ow we e: : choroby zapalne jelit, receptor dla naskórkowego czynnika wzrostu, czynnik martwicy nowotworów α, czynnik jądrowy κB. Original paper/Artykuł oryginalny Abstract I In nt tr ro od du uc ct ti io on n: : The role of epithelial growth factor receptor (EGFR) in inflammatory bowel diseases (IBD) pathogenesis has not been fully elucidated. Overexpression of EGFR in colonic inflamed mucosa in patients with IBD has been observed by some authors. Moreover some studies confirm the role of EGFR in upregulating nuclear factor κB (NF-κB) and tumor necrosis factor-α (TNF-α) expression, which may lead to pronounced inflammatory response in IBD. A Ai im m: : To evaluate the expression of EGFR, NF-κB and TNF-α in remission and active phase of Crohn disease (CD) and ulcerative colitis (UC). M Ma at te er ri ia al l a an nd d m me et th ho od ds s: : Biopsy specimens from colonic mucosa were taken at colonoscopy from 62 patients with CD, 92 patients with UC and from 18 healthy subjects with normal colonic mucosa (control). The expression of EGFR, NF-κB and TNF-α was evaluated by immunohistochemical staining. R Re es su ul lt ts s: : The colonic mucosal immunoexpression of EGFR in active phase of IBD was significantly lower compared to the remission. The immunoexpression of NF-κB and TNF-α was si gnificantly higher in the active disease phase of IBD than in remission. The results suggest that EGFR does not promote inflammation in IBD but most probably is involved in mucosal regeneration in IBD. C Co on nc cl lu us si io on ns s: : High expression of NF-κB and TNF-α in active phases of UC and CD confirm their proinflammatory role in these diseases.

Protection against ulcerative colitis and colorectal cancer by evodiamine via anti‑inflammatory effects

“…The promoter region of il-8 has binding sites for transcription factors, such as activator protein 1 and nF-κB (48). once activated, nF-κB may cause the overexpression of proinflammatory cytokines, thereby promoting a Th1-dependent lymphocyte immune response (49). il-6 promotes the chemotaxis of neutrophils, promotes colonic necrosis and ultimately tissue destruction (50).…”