Expression of epithelial calcium transport system in rat cochlea and vestibular labyrinth

Yamauchi, Daisuke; Nakaya, Kazuhiro; Raveendran, Nithya N.; Harbidge, Donald G.; Singh, Ruchira; Wangemann, Philine; Marcus, Daniel C.

doi:10.1186/1472-6793-10-1

Cited by 70 publications

(52 citation statements)

References 36 publications

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“…3). The failure to lower the endolymphatic Ca 2+ concentration may be due to a lack of Ca 2+ absorption via acid-sensitive epithelial Ca 2+ channels [23,31,48]. Whether and how loss of pendrin leads to a loss of expression of Ca 2+ transporters, as observed in the kidney [49], remains to be determined.…”

Section: Secondary Consequence Of a Lack Of Pendrin Expression: Oxidamentioning

confidence: 99%

The Role of Pendrin in the Development of the Murine Inner Ear

Wangemann¹

2011

Cell Physiol Biochem

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Enlargement of the vestibular aqueduct (EVA) is a common inner ear malformation found in children with sensorineural hearing loss that is frequently associated with loss-of-function or hypo-function mutations of SLC26A4. SLC26A4 codes for pendrin, which is a protein that is expressed in apical membranes of selected epithelia and functions as an anion exchanger. The comparatively high prevalence of EVA provides a strong imperative to develop rational interventions that delay, ameliorate or prevent hearing loss associated with this phenotype. The development of rational interventions requires a fundamental understanding of the role that pendrin plays in the normal development of hearing, as well as a detailed understanding of the pathobiologic mechanisms that, in the absence of fully functional pendrin, lead to an unstable hearing phenotype, with fluctuating or progressive loss of hearing. This review summarizes studies in mouse models that have focused on delineating the role of pendrin in the physiology of the inner ear and the pathobiology that leads to hearing loss.

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Section: Secondary Consequence Of a Lack Of Pendrin Expression: Oxidamentioning

confidence: 99%

The Role of Pendrin in the Development of the Murine Inner Ear

Wangemann¹

2011

Cell Physiol Biochem

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“…Ca 2þ concentration of the endolymph is maintained at relatively low levels (cochlea at 23 mM and vestibule at 280 mM versus perilymph at 1 mM) (18). This is thought to be accomplished by a Ca 2þ absorptive system expressed in cochlear and vestibular tissues (19). It is not known how this system is regulated, but it has been implicated in mediating the association between BPPV and osteoporosis (20).…”

Section: Discussionmentioning

confidence: 99%

Preliminary Report on the Investigation of the Association Between BPPV and Osteoporosis Using Biomarkers

Sacks

Parham²

2015

Otology &Amp; Neurotology

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Despite a strong correlation between DEXA scan results and otolin-1 levels, there were no significant correlations between otolin-1 and P1NP or NTX. This suggests that the association between osteoporosis and BPPV is complex, but not likely to be causal. Although more work is needed to elucidate these relationships, this preliminary finding has important practical implications for BPPV in that proactive management of osteoporosis, per se, would not be expected to have benefits in management of BPPV.

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“…The Ca 2+ absorptive system comprises an apical membrane entry pathway (TRPV5 and TRPV6 channels), a cytosolic Ca 2+ buffer protein (calbindin-D9K and calbindin-D28K), and basolateral Ca 2+ exit pathways (sodium-calcium exchangers -NCX-) and plasma membrane Ca 2+ -ATPases (PMCA) [31] . Expression of these transporters can be regulated by the active form of vitamin D, i.e., 1,25-(OH) 2 vitamin D3 [30] .…”

Section: Discussionmentioning

confidence: 99%

A Pilot Study Using Intratympanic Methylprednisolone for Treatment of Persistent Posterior Canal Benign Paroxysmal Positional Vertigo

Pérez¹,

Franco²,

Oliva³

et al. 2016

Int Adv Otol

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OBJECTIVE:To assess the effect of intratympanic methylprednisolone (ITMP) in posterior canal benign paroxysmal positional vertigo (BPPV) that fails treatment involving repositioning maneuver in a case series. MATERIALS and METHODS:Nine patients with persistent posterior canal BPPV after 6 or more repositioning maneuvers were treated by ITMP (two weekly doses of 0.3-0.4 mL at 40 mg/mL) before repeating the repositioning procedures. RESULTS:Following ITMP treatment, 7 out of 9 patients were relieved of their symptoms and did not exhibit positional nystagmus after 1 or 2 repositioning maneuvers. The number of positional maneuvers performed before and after ITMP treatment in these 7 patients showed a statistically significant (p=0.016) reduction in the amount of repositioning treatments required. None of the 7 respondent patients showed any relapses during the follow-up period (follow-up range: 11-95 months). CONCLUSION:Administering ITMP before resuming repositioning procedures can be a useful treatment for persistent BPPV of the posterior canal. Intratympanic (IT) steroids are often used to treat inner ear disorders such as sudden idiopathic sensorineural hearing loss, autoimmune hearing loss, and Ménière's disease [14] . Corticosteroids exert their effects in the inner ear after interacting with intracellular glucocorticoid receptors by producing metabolic and anti-inflammatory effects. It is also known that glucocorticoid receptors are widespread throughout the inner ear, including semicircular canal duct epithelial cells, where they facilitate cation absorption via sodium channels [15][16][17] . KEYWORDS:Thus, considering the possibility of an inflammatory process of the labyrinth or an imbalance of Na + and Ca 2+ in the endolymph could be related with the intractability of BPPV, we have carried out a pilot study to assess the effect of IT methylprednisolone (ITMP) in persistent posterior canal BPPV. MATERIALS and METHODSThis prospective study included patients from 3 different hospitals. From January 2006 to March 2014, we diagnosed 187 patients affected from unilateral posterior canal BPPV. None of them had any symptoms or signs of central nervous system (CNS) disease. A complete otoneurological examination, including otoscopy, audiometry, head thrust test, spontaneous nystagmus recording, gaze-evoked nystagmus test, cover test, and Romberg and Fukuda tests, were performed in all the cases.The diagnosis of posterior canal BPPV was made by Dix-Hallpike test, showing a mixed vertical and torsional nystagmus beating toward the undermost ear, with appropriate latency and duration, and the direction of the nystagmus reversed on resuming the upright position. In every patient, the roll test and head hyperextension test were also performed in order to rule out lateral or superior canal BPPV.Patients with BPPV were treated by Epley or Semont maneuvers. We carried out only one of those maneuvers in every session. Each session, weekly programmed, began with a Dix-Hallpike test; if it was positive for the same posterior...

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Expression of epithelial calcium transport system in rat cochlea and vestibular labyrinth

Cited by 70 publications

References 36 publications

The Role of Pendrin in the Development of the Murine Inner Ear

The Role of Pendrin in the Development of the Murine Inner Ear

Preliminary Report on the Investigation of the Association Between BPPV and Osteoporosis Using Biomarkers

A Pilot Study Using Intratympanic Methylprednisolone for Treatment of Persistent Posterior Canal Benign Paroxysmal Positional Vertigo

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