Expression of epidermal growth factor receptor in urinary bladder cancer metastases

Bue, Peter; Wester, Kenneth; Sjöström, Anna; Holmberg, Anders; Nilsson, Sten; Carlsson, Jörgen; Westlin, Jan‐Erik; Busch, Christer; Malmström, Per‐Uno

doi:10.1002/(sici)1097-0215(19980413)76:2<189::aid-ijc4>3.3.co;2-s

Cited by 6 publications

(8 citation statements)

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“…In bladder cancer, amplifications or rearrangements in the EGFR gene are not frequently detected [5]. The proportion of patients with bladder cancer (over‐)expressing EGFR protein has been reported to be 27–86%[6–9]. Some studies have shown that expression of EGFR increases with T category and grade, but apparently in a nonlinear pattern.…”

Section: Introductionmentioning

confidence: 99%

“…Some studies have shown that expression of EGFR increases with T category and grade, but apparently in a nonlinear pattern. A marked up‐regulation was reported in precursor lesions (carcinoma in situ , CIS) than in superficial tumours, but there was no further increase when comparing CIS and muscle‐invasive tumours, nor between primary tumours and corresponding metastases [8,10]. Another study showed a significant increase in EGFR protein levels comparing T1 and T2–4 tumours [11].…”

Section: Introductionmentioning

confidence: 99%

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Expression of the epidermal growth factor receptor family in normal and malignant urothelium

Røtterud¹,

Nesland

Berner

et al. 2005

BJU International

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RESULTSAll NU samples expressed ERBB4, none expressed ERBB2 and two expressed EGFR; all staining was uniform throughout all cell layers. ERBB2 expression increased and ERBB4 decreased from normal samples to carcinomas. There was no difference between NMCs and MCs in ERBB2, ERBB3 and ERBB4, but the NMCs expressed more EGFR than both NU and MC samples. There were no associations with T category, grade or survival. All combinations of expression levels for the four receptors were detected, with no dominant profile. CONCLUSIONWe hypothesise that: (i) ERBB4 is important for differentiation in NU; (ii) ERBB2 is upregulated with carcinogenesis in the urinary bladder but does not discriminate between bladder cancer with or without metastases; (iii) EGFR may be a marker of indolent disease. A current hypothesis, that superficial layers of NU do not express EGFR and thus protect the basal cells from the mitogenic effect of urinary EGF, is challenged.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Expression of the epidermal growth factor receptor family in normal and malignant urothelium

Røtterud¹,

Nesland

Berner

et al. 2005

BJU International

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“…Both Bue et al and Ravery et al have found similar findings with CIS and EGFR status in their patients with TCC bladder. 25,31 Authors had observed no significant association of muscle invasion of primary tumour (p=0.25) and stage of tumour (p=0.39) with the EGFR score in tumour specimens. Chow et al observed no significant correlation between EGFR status and TNM staging (p=0.291).…”

Section: Discussionmentioning

confidence: 95%

Correlation of epidermal growth factor receptor score with prognostic variables in transitional cell carcinoma of urinary bladder among north-eastern Indian population

Barua¹,

Das²,

Baruah³

et al. 2018

Int Surg J

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Background: Epidermal growth factor receptor (EGFR) has demonstrated over expression in bladder tumours and correlation with stage and grade of tumours. The aim of present study was to find the relation between score of the EGFR in Transitional Cell Carcinoma (TCC) of bladder and its various prognostic variables.Methods: This is a retrospective study conducted in Dept of Urology, Gauhati Medical College Hospital between Dec 2016 and July 2017. Forty cases of TCC bladder that were operated either by TURBT or radical cystectomy have been taken. However, patients with CKD, pre-existing systemic disease and UTI were excluded from the study. Presence of EGFR and its score were analysed. The rating was done as 0 (non-immunoreactive), 1+ (weak), 2+ (moderate) and 3+ (strong). The correlation between EGFR score and the various factors like age, sex, stage, size of tumour, presence of CIS, tumour grade, muscle invasion, number of tumours and type of stalk were evaluated statistically using chi square tests.Results: Average age is 59.825 years and male to female ratio is 5.6:1. EGFR score is not significantly related with age, sex, stage of disease, muscle invasiveness or number of tumours whereas size of tumour, presence of CIS changes, grade of TCC and type of tumour stalk bears statistically significant relation with EGFR score.Conclusions: Studies have shown EGFR positivity to be associated with high tumour stage, tumour progression, and poor clinical outcome. Authors have found size >3cm, CIS changes, high grade tumours and broad-based stalks to be significantly associated with higher EGFR scores among patients with TCC of bladder.

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“…Los últimos estudios publicados confirman lo ya conocido anteriormente, que HER-2-neu se sobreexpresa en el cáncer de vejiga, con una significación estadística para estadios avanzados, así como con una asociación a un peor pronóstico. El aumento de expresión de HER-2-neu se encuentra también en las metástasis del primario vesical llegando a encontrarse incluso en el 65% de las metástasis analizadas, un porcentaje similar al encontrado en el tumor primario (Bue et al) 18 .…”

Section: Her-2-neu: ¿Posible Diana Del Carcinoma Vesical?unclassified

HER-2-neu: ¿posible diana del carcinoma vesical?

et al. 2006

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Expression of epidermal growth factor receptor in urinary bladder cancer metastases

Cited by 6 publications

References 0 publications

Expression of the epidermal growth factor receptor family in normal and malignant urothelium

Expression of the epidermal growth factor receptor family in normal and malignant urothelium

Correlation of epidermal growth factor receptor score with prognostic variables in transitional cell carcinoma of urinary bladder among north-eastern Indian population

HER-2-neu: ¿posible diana del carcinoma vesical?

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