Expression of endothelin-1 in laryngocarcinoma tissues and its clinical significance

Wang, Shaozhong; Wu, Jian; Song, Yisa; Zhong, Huiling

doi:10.3892/ol.2016.4406

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…The present study showed a significant association of ET-1 expression with the advanced stage of CSCC cases and positive lymph node metastasis. Similarly, high ET-1 expression and higher stages of laryngeal carcinoma were found to be associated in other studies (7,19). This could be explained by the fact that the ET-1/ETAR axis can promote EMT, thus enhancing invasion and metastasis.…”

Section: Discussionsupporting

confidence: 63%

Ezh2, endothelin-1, and cd34 as biomarkers of aggressive cervical squamous cell carcinoma: an immunohistochemical study

Fathy

Abdelrahman²

2018

TJPATH

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Objective: Cervical cancer has an increasing incidence in developing countries with a predominance of squamous cell carcinoma. In this work, we aimed to analyze the role of EZH2, Endothelin-1, and CD34 as indicators of the aggressiveness in cervical squamous cell carcinoma. Material and Method:Immunohistochemical expression of EZH2, Endothelin-1, and CD34 was studied in 54 paraffin-embedded tissue specimens of cervical squamous cell carcinoma. Their correlation to the clinicopathologic features and the potential angiogenic role were analyzed.Results: High EZH2 expression was noted in 78% of cervical squamous cell carcinoma with a significant relation with tumor grade, FIGO stage and lymph node metastasis (p=<0.001, p=0.007, p=0.03 respectively). Endothelin-1 overexpression was detected in 63% of the studied cases with a significant association with tumor size, FIGO stage and lymph node metastasis (p=0.009, p=0.002, p=0.02 respectively). High CD34 expression (MVD) was noted in 56% of the cases and associated with the tumor size, FIGO stage and lymph node metastasis (p<0.001, p<0.001, p=0.04 respectively). The three markers were significantly associated (p<0.05).Conclusion: EZH2, ET-1, and CD34 may act as biomarkers of aggressive cervical squamous cell carcinoma. They may contribute to the signaling pathway of angiogenesis. Therefore, they could potentially be used in targeted therapy.

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Section: Discussionsupporting

confidence: 63%

Ezh2, endothelin-1, and cd34 as biomarkers of aggressive cervical squamous cell carcinoma: an immunohistochemical study

Fathy

Abdelrahman²

2018

TJPATH

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“…In the current study, most of our studied meningioma cases (84%) showed positive MUC4 immunohistochemical expression and this was in concordance with Kong et al, 2020, Matsuyama et al, 2018 and Hasaneen et al, 2020 as 100%, 92.9% and 83.3% of their enrolled meningioma cases showed MUC4 positive immunohistochemical expression respectively [18][19][20] . Kong et al, 2020 reported that highest positivity was reported in meningothelial and secretory meningioma (100%), followed by 97.8% in angioma-tous meningiomas, 90.2% in atypical meningiomas and lowest in fibroblastic meningioma (13.5%) [18] . Similar figures were reported in our study as 100%; 12/12 of meningothelial and 7/7 of atypical meningiomas were positive for MUC4 followed by angiomatous meningioma (75%, 3/3) while only (1/6, 16.7%) of fibroblastic meningiomas were MUC4 positive.…”

Section: Discussionsupporting

confidence: 91%

Immunohistochemical Expression of MUC4, CD44, and Ki67/MIB1 in Different Meningioma Grades. A New Promise to Overcome the Chemoresistance Problem in Aggressive Meningioma

SARA E. KHALIFA, M.D.; RASHA R.

2023

The Medical Journal of Cairo University

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Background: MUC4 and CD44 have been addressed as major players in the progression and chemoresistance of several tumors. Aim of Study:We aimed to elucidate the role of MUC4, CD44, and ki67 in meningiomas to detect if anti-cancer agents with mucin-depleting and proteolytic effects could help in overcoming chemoresistance in meningiomas.Material and Methods: Fifty meningioma cases were immunohistochemically tested for CD44 and MUC4. In addition to grading of meningioma, Ki67/MIB 1 labeling index was evaluated.Results: MUC4 and CD44 were expressed in 84% and 100% of our cases respectively. Significant correlation (p=0.007) was detected between meningioma subtypes and MUC4 intensity being highest in meningothelial and lowest in fibroblastic variant. Moreover, advanced meningioma grades were positively correlated with CD44 intensity ( p<0.001) and Ki67/MIB1 labeling index (p<0.001). In addition, both CD44 and MUC4 immunohistochemical expression showed a significant positive association with Ki67/MIB 1 labeling index (p=0.011 and p=0.004) respectively. Conclusion:MUC4 and CD44 are upregulated in advanced meningioma WHO grades II and III and correlated with a higher Ki67/MIB 1 labeling index. Subsequently, they can adversely influence the outcome and recurrence rate in meningioma and can be targeted by an agent with mucolytic and proteolytic effects helping in overcoming the common problem of chemoresistance in aggressive meningiomas.

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“…The pathological type of laryngeal cancer is mainly squamous cell carcinoma. Studies have shown that the morbidity of laryngeal cancer is increasing (2,3). In the United States, the increase of new patients with laryngeal cancer total 12,000 cases each year.…”

Section: Introductionmentioning

confidence: 99%

Expression and clinical significance of miRNA-145 and miRNA-218 in laryngeal cancer

Guo

Hua

et al. 2019

Oncol Lett

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Expression of miRNA-145 and miRNA-218 in serum of patients with laryngeal cancer and the relationship between them and the clinicopathological parameters and prognosis were investigated. The clinical medical records of 132 patients with laryngeal cancer, who were admitted to Guangdong Second Provincial General Hospital from February 2009 to March 2014, were retrospectively analyzed and comprised the study group. The data of physical examinations of 56 healthy volunteers who took physical examinations in the same hospital comprised the control group. RT-qPCR was used to detect the expression levels of miRNA-145 and miRNA-218 in serum of the patients in the two groups. According to the relative expression levels of miRNA-145 and miRNA-218 in serum of the patients in the study group on the day when they left hospital, the study group was divided into the high expression group (n=73 patients) and the low expression group (n=59 patients). The patients received a 48-month follow-up visit and their survival condition was recorded and the Kaplan-Meier was used to carry out the survival analysis. The expression levels of miRNA-145 and miRNA-218 in serum of the patients in the study group were lower than those in the control group (P<0.05). The median survival time of the patients in the high expression group was 30 months while the median survival time of the patients in the low expression group was 26 months. The expression levels of miRNA-145 and miRNA-218 in serum of patients with laryngeal cancer decreased, the higher the expression levels of miRNA-145 and miRNA-218 in serum of patients with laryngeal cancer were, the better the prognosis was. miRNA-145 and miRNA-218 were used as indicators of assessing the prognosis of patients with laryngeal cancer.

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Expression of endothelin-1 in laryngocarcinoma tissues and its clinical significance

Cited by 4 publications

References 7 publications

Ezh2, endothelin-1, and cd34 as biomarkers of aggressive cervical squamous cell carcinoma: an immunohistochemical study

Ezh2, endothelin-1, and cd34 as biomarkers of aggressive cervical squamous cell carcinoma: an immunohistochemical study

Immunohistochemical Expression of MUC4, CD44, and Ki67/MIB1 in Different Meningioma Grades. A New Promise to Overcome the Chemoresistance Problem in Aggressive Meningioma

Expression and clinical significance of miRNA-145 and miRNA-218 in laryngeal cancer

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