Expression of E-cadherin in primary oral squamous cell carcinoma and metastatic lymph nodes: An immunohistochemical study

Kaur, Gurkiran; Carnelio, Sunitha; Rao, Nirmala N; Rao, Laxmi

doi:10.4103/0970-9290.49075

Cited by 44 publications

(10 citation statements)

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“…Some studies have focussed on the invasive tumour front [33,38] while other studies have examined expression in random areas [24,36,37,39] within the tumour. It would, however, appear from the results in the present study and other studies on OSCC [16,17,25,27,28,35,36,39] that E-cadherin and β-catenin are probably not the key determinants for regional metastases in OSCC.…”

Section: Discussioncontrasting

confidence: 82%

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Study of β-catenin, E-cadherin and vimentin in oral squamous cell carcinoma with and without lymph node metastases

et al. 2014

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BackgroundDespite great improvement in the surgical treatment and adjunctive therapy for oral squamous cell carcinoma (OSCC), prognosis remains dismal in advanced cases. Regional metastatic disease is known to reduce recurrence free survival and disease specific survival significantly. The present study was conducted to evaluate the role of cell adhesion molecules β-catenin, E-cadherin and vimentin in predicting tumour metastasis of OSCC.MethodsA total of sixty cases of oral squamous cell carcinoma were included for the study which comprised of 30 cases with lymph node metastases and 30 cases without metastases. Immunohistochemistry was performed for β-catenin, E-cadherin and vimentin on both the test groups along with 30 controls from normal buccal mucosa and inflammatory lesions each.ResultsThere was no significant difference between the immunoreactivity for β-catenin, E-cadherin and vimentin between OSCC with and without lymph node metastases. Vimentin immunopositivity was noted with varying intensity in all cases of OSCC.ConclusionsE-cadherin and β-catenin are probably not the key determinants for regional metastases in OSCC. The role of vimentin expression in OSCC and metastases is controversial and needs to be studied further.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/6506095201182002.

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Section: Discussioncontrasting

confidence: 82%

“…Down regulation and loss of E-cadherin was associated with lymph node metastases and advanced stage of OSCC according to various studies [18,24-26] while few studies [16,17,27,28] failed to prove this prognostic value. The present study followed the latter trend.…”

Section: Discussionmentioning

confidence: 99%

Study of β-catenin, E-cadherin and vimentin in oral squamous cell carcinoma with and without lymph node metastases

et al. 2014

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“…Multivariate analysis showed significant association of ECAD mRNA with differentiation and stage of disease. Earlier studies have reported that mRNA levels of ECAD decreased significantly in metastatic tumors as compared to non-metastatic tumors in nasopharyngeal carcinoma (Kaur et al, 2009). In the present study, Kaplan Meir's survival analysis indicated that lower ECAD mRNA expression depicted lower survival.…”

Section: Discussionsupporting

confidence: 61%

Correlation between Loss of E-cadherin, Matrix-metalloproteinases and c-Jun expression in Oral Carcinogenesis

Vajaria¹,

Patel²,

Begum³

et al. 2017

AJOM

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Background: Earlier invitro studies have observed that loss of E-cadherin is responsible for progression and metastasis of cancer by upregulation of c-Jun protein. There being lack of simultaneous evaluation of matrix metalloproteinase (MMP) -2 and -9, E-cadherin and c-Jun mRNA and protein. Objective: This study aimed to correlate the above-mentioned parameters to evaluate the pathway of oral carcinogenesis. Methods: The study included 100 controls, 50 patients with oral precancerous conditions (OPC) and 100 oral cancer patients. MMPs were evaluated by gelatin zymography, ECAD and CJUN mRNA and protein expression by semi quantitative RT-PCR and western blot respectively. Results: The levels of active and total MMP-2 and MMP-9 were significantly higher in patients with OPC and oral cancer patients as compared to controls. A significant increase in truncated E-cadherin and c-Jun protein was observed in malignant tissues as compared to adjacent normal tissues while CJUN mRNA levels were comparable. Higher values of c-Jun protein and MMPs, and lower values of ECAD mRNA were associated with reduced overall survival. A positive correlation was observed between truncated E-cadherin, MMPs and c-Jun protein. Conclusions: MMPs modulate cell-cell adhesion by increasing truncation of E-cadherin resulting in loss of E-cadherin which is responsible for upregulation of c-Jun protein in oral cancer.

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“…However, Kaur et al demonstrated that loss of E‐cadherin had an essential role in OSCC dedifferentiation; this protein's lack of expression could lead to OSCC invasion and progression. 42 Other reports showed that the tumor stage was related to E‐cadherin expression. 43 However, oral SCC is a revolute disorder; therefore, cadherin's role needs to be more studied for clarification.…”

Section: Discussionmentioning

confidence: 99%

“…Still, no statically significant association was observed between histopathological grades of OSCC samples and cadherin genotypes. However, Kaur et al demonstrated that loss of E‐cadherin had an essential role in OSCC dedifferentiation; this protein's lack of expression could lead to OSCC invasion and progression 42 . Other reports showed that the tumor stage was related to E‐cadherin expression 43 .…”

Section: Discussionmentioning

confidence: 99%

Effect of CDH1 and CDH2 genes polymorphisms in oral squamous cell carcinoma susceptibility in a sample of Iranian population: A case‐control study

Kadeh

Parsamanesh

Miri‐Moghaddam

2023

Health Science Reports

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Expression of E-cadherin in primary oral squamous cell carcinoma and metastatic lymph nodes: An immunohistochemical study

Cited by 44 publications

References 0 publications

Study of β-catenin, E-cadherin and vimentin in oral squamous cell carcinoma with and without lymph node metastases

Study of β-catenin, E-cadherin and vimentin in oral squamous cell carcinoma with and without lymph node metastases

Correlation between Loss of E-cadherin, Matrix-metalloproteinases and c-Jun expression in Oral Carcinogenesis

Effect of CDH1 and CDH2 genes polymorphisms in oral squamous cell carcinoma susceptibility in a sample of Iranian population: A case‐control study

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