Expression of DOG1, CD117 and PDGFRA in Gastrointestinal Stromal Tumors and Correlations with Clinicopathology

Sun, Xia; Feng, Zhanjun; Huang, Peng; Wang, Hao; Sui, Xing-Ling

doi:10.7314/apjcp.2012.13.4.1389

Cited by 18 publications

(5 citation statements)

References 26 publications

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“…This observation was in agreement with that of Ahmed et al [9], Klieser et al [10], Lopes et al [11] Alqusous et al [12], Vij et al [13], Yacob et al [14], Din et al [16], Li et al [17], Cao et al [18], Sui et al [19], Tazawa et al [20], Kang et al [21], and Kkrishnappa et al [22]. These are in contrast with the two studies of Antonescu et al [7] and Bhalgami et al [15] which found slightly more in the small intestine than stomach.…”

Section: Discussionsupporting

confidence: 91%

“…One of the studies conducted in Pakistan, Din et al [16], one from China, Sun et al [19], and one from Korea, Kang et al [21], also found that majority were spindle type (84.7%, 83%, 88.2%), followed by epithelioid cell type (12.5%, 10%, 9.3%), and the minority were mixed spindled-epithelioid cell type (2.7%, 8%, 2.5%). However, the study of Klieser et al [10] in Europe found that the majority were spindle type (61.2%), while the epithelioid cell type (19.4%) was equally found with the mixed spindled-epithelioid cell type (19.4%).…”

Section: Discussionmentioning

confidence: 99%

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Gastrointestinal stromal tumor: clinicopathological characteristics and pathologic prognostic analysis

Jumniensuk

Charoenpitakchai

2018

World J Surg Onc

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ObjectiveThis study aimed to understand clinicopathological characteristics of gastrointestinal stromal tumors (GISTs) and correlation between pathologic features and clinical outcome.MethodsWe used 76 cases diagnosed as primary GISTs during January 2007 to July 2017 at Army Institute of Pathology, Thailand. Clinical, survival, and pathological data were collected and analyzed.ResultsAges of the patients ranged from 15 to 88 years (M:F = 1:1). The most common presentation was gastrointestinal bleeding (39.7%). The most common site was the stomach (64.5%). Tumor size ranged from 0.6 to 25.5 cm (average 8.78 cm). Histologic types were spindle cell type (75%), mixed spindled-epithelioid type (17.1%), and epithelioid type (7.9%). The majority of histologic subtype was diffuse hypercellularity (67.1%). Tumor necrosis was found in 38.1% and 80% showed low mitotic counts. Most gastrointestinal stromal tumors (27.6%) are low-risk category according to Miettinen and Lasota’s algorithm. Metastasis was found in 27.7%, mostly occurs within 2 years, and is correlated with tumor size > 10 cm (P = 0.023), non-spindle cell histologic type (P = 0.027), mitotic count > 5/5mm2 (P = 0.000), myxoid change (P = 0.011), and mucosal invasion (P = 0.002). Recurrence was found in 8.1%, mostly occurs within 7 years, and correlated with myxoid change (P = 0.045).ConclusionWe found that most of GISTs show spindle cell type and low-risk category. Metastasis was correlated with tumor size > 10 cm, non-spindle cell histologic type, mitotic count > 5/5mm2, myxoid change, and mucosal invasion. Recurrence was correlated with myxoid change.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Gastrointestinal stromal tumor: clinicopathological characteristics and pathologic prognostic analysis

Jumniensuk

Charoenpitakchai

2018

World J Surg Onc

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“…A study from China showed CD117 positivity in 94.5% and CD34 positivity in 86.2% cases (Cao et al, 2010). Another Asian study showed CD117 and DOG 1 positivity in 90.5% and 84.1% cases respectively (Sun et al, 2012).…”

Section: Discussionmentioning

confidence: 94%

“…However, ASMA expression is a statistically significant favorable prognostic factor in gastric and small intestinal GISTs (Tworek et al, 1997;Miettenin et al, 2005;Miettenin et al, 2006). The prognostic and predictive potential of immunohistochemical stains in GIST has been studied but results are conflicting and inconclusive (Sun et al, 2012;Demir et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal Stromal Tumors: A Clinicopathologic and Risk Stratification Study of 255 Cases from Pakistan and Review of Literature

Din¹,

Ahmad²,

Arshad³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Purpose: To describe the clinicopathological features of gastrointestinal stromal tumors (GIST) diagnosed in our section and to perform risk stratification of our cases by assigning them to specific risk categories and groups for disease progression based on proposals by Fletcher et al and Miettinen and Lasota. Materials and Results: We retrieved 255 cases of GIST diagnosed between 2003 and 2014. Over 59% were male. The age range was 16 to 83 years with a mean of 51 years. Over 70% occurred between 40 and 70 years of age. Average diameter of tumors was 10 cms. The stomach was the most common site accounting for about 40%. EGISTs constituted about 16%. On histologic examination, spindle cell morphology was seen in almost of 85% cases. CD117 was the most useful immunohistochemical antibody, positive in 98%. Risk stratification was possible for 220 cases. Based on Fletcher's consensus proposal, 62.3 gastric, 81.8% duodenal, 68% small intestinal, 72% colorectal and 89% EGISTs were assigned to the high risk category; while based on Miettinen and Lasota's algorithm, about 48% gastric, 100% duodenal, 76% small intestinal, 100% colorectal and 100% EGISTs in our study were associated with high risk for disease progression, tumor metastasis and tumor related death. Follow up was available in 95 patients; 26 were dead and 69 alive at follow up. Most of the patients who died had high risk disease and on average death occurred just a few months to a maximum of one to two years after initial surgical resection. Conclusions: Epidemiological and morphologic findings in our study were similar to international published data. The majority of cases in our study belonged to the high risk category.

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“…As a specific marker of GISTs, CD117 has good sensitivity and was highly expressed in nearly 85% to 94% of cases [16]. The high sensitivity and specificity of CD117 is a useful marker in differentiating GIST from other mesenchymal tumors of the gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 99%

Surgical resection should be taken into consideration for the treatment of small gastric gastrointestinal stromal tumors

Yang

Feng

et al. 2013

World J Surg Onc

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BackgroundThe National Comprehensive Cancer Network (NCCN) recommends conservative follow-up for gastric gastrointestinal stromal tumors (GISTs) less than 2 cm. The aim of the present study was to investigate the clinical and pathological features of small gastric GISTs, re-evaluate the risk potential, and discuss the treatment strategy of small gastric GISTs.MethodsIn this retrospective study, 63 cases of small gastric GISTs (less than 2 cm) were resected surgically from May 2010 to March 2013 in our department. Clinicopathological factors were collected and the malignant potential of small gastric GISTs was analyzed.ResultsThe mitotic index of 14 out of 63 cases (22.22%) exceeded 5. The malignant potential of small gastric GISTs was related to tumor location (P = 0.0218). The mitotic index of 4 out of 8 GISTs (50%) located in gastric cardia exceeded 5, 8 out 28 GISTs (28.57%) located in the gastric fundus exceeded 5, and only 2 out of 27 GISTs (7.41%) located in the gastric body exceeded 5. We also discovered a good consistency between mitotic index and Ki-67 expression of small gastric GISTs.ConclusionsGastric GISTs less than 2 cm also have malignant potential. Thus, we recommended surgical resection of all small gastric GISTs once diagnosed.

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Expression of DOG1, CD117 and PDGFRA in Gastrointestinal Stromal Tumors and Correlations with Clinicopathology

Cited by 18 publications

References 26 publications

Gastrointestinal stromal tumor: clinicopathological characteristics and pathologic prognostic analysis

Gastrointestinal stromal tumor: clinicopathological characteristics and pathologic prognostic analysis

Gastrointestinal Stromal Tumors: A Clinicopathologic and Risk Stratification Study of 255 Cases from Pakistan and Review of Literature

Surgical resection should be taken into consideration for the treatment of small gastric gastrointestinal stromal tumors

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