Expression of Distinct Desmocollin Isoforms in Human Epidermis

King, Ian A.; Tabiowo, Anne; Purkis, Patricia E.; Leigh, Irene M.; Magee, Anthony I.

doi:10.1111/1523-1747.ep12471843

Cited by 32 publications

(18 citation statements)

References 39 publications

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“…Dsc3 and Dsg3 are found most abundantly in the basal, proliferative layer and first suprabasal layers of stratified epithelia [31,32]. Dsc1 and Dsg1 are first expressed in the suprabasal layers of the epidermis but become concentrated in the upper, most differentiated layers [32,33]. Dsg4 is also expressed primarily in the upper layers of the skin, as well as in the hair follicle [7,34].…”

Section: Regulation Of Desmosomal Cadherin Expressionmentioning

confidence: 99%

Discriminating roles of desmosomal cadherins: Beyond desmosomal adhesion

Dusek¹,

Godsel²,

Green³

2007

Journal of Dermatological Science

119

111

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Section: Regulation Of Desmosomal Cadherin Expressionmentioning

confidence: 99%

Discriminating roles of desmosomal cadherins: Beyond desmosomal adhesion

Dusek¹,

Godsel²,

Green³

2007

Journal of Dermatological Science

119

111

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“…In experiments using pieces of stratum corneum and an ultrastructural endpoint, proteases alone were ineffective in digesting or altering desmosomes, but glycosidase treatment followed by protease treatment succeeded in significantly reducing the size of those desmosomes [20]. Analysis of proteins in the stratum corneum has been used to demonstrate the progressive degradation of the desmosomal proteins desmoglein I [19,21,22], desmocollin [23], desmoplakin (Bernard,unpublished,cited in [24]) and corneodesmosin [25]. Proteases have been isolated from stratum corneum and several are expressed or activated in epidermis as late products of terminal differentiation: stratum corneum chymotryptic enzyme (SCCE) [26]; stratum corneum tryptic enzyme (SCTE) [27,28]; cathepsin D [29]; and stratum corneum thiol protease (SCTP/cathepsinL2) [24,30].…”

Section: Mechanism Of Epidermal Desquamationmentioning

confidence: 99%

Epidermal desquamation

Milstone¹

2004

Journal of Dermatological Science

125

103

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Epidermal desquamation, a continuous but insensible bodily activity, is largely ignored unless the rate or amount of scale production becomes abnormal. It is the last topic to be considered in any serious discussion of epidermal growth and differentiation, but is becoming an increasingly fertile ground for investigation. This review summarizes: (a) methods for measuring desquamation; (b) variables that affect normal desquamation; (c) mechanisms of desquamation; (d) the role of desquamation in nutritional homeostasis; and (e) the role of desquamation as a first line of defense. Consideration is given to whether desquamation might be harnessed to eliminate or remediate toxins that have accumulated in the body.

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“…The desmocollins exist in three different isoforms, Dsc1, 2 and 3, that demonstrate differentiation‐specific expression through the epidermal layers. Dsc1 is found mainly in the upper spinous and granular layers, Dsc2 in the basal layer, and Dsc3 throughout the whole epidermis, but mainly in the basal and spinous layers 17–23 …”

mentioning

confidence: 99%

Acquired palmoplantar keratoderma and immunobullous disease associated with antibodies to desmocollin 3

et al. 2007

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We present a case of immunobullous disease with an impressive acquired palmoplantar keratoderma (PPK) and unique antigenicity. The palms of the patient showed hyperkeratotic ridges with a tripe pattern that decreased with the amelioration of the immunobullous condition. The histopathology of perilesional skin (blister) demonstrated eosinophilic spongiosis and suprabasal blistering as in pemphigus vulgaris. In palmar skin, acantholysis, intraepidermal pustules, papillomatosis and marked hyperkeratosis were observed. Direct and indirect immunofluorescence displayed intraepidermal intercellular IgG staining as well as linear IgG staining along the epidermal basement membrane zone. Immunochemical assays revealed IgG antibodies to the desmosomal protein desmocollin 3 and to the hemidesmosomal proteins BP230 and LAD-1. Affinity-purified antidesmocollin 3 serum IgG bound to monkey oesophagus in the typical pemphigus pattern. Desmocollins are transmembrane proteins of the desmosome. Desmosome diseases may cause hereditary PPK. In our patient with acquired PPK, we hypothesize that the antibodies to desmocollin 3 were, apart from their role in eliciting the pemphigus-like blistering disease, also implicated in the pathogenesis of the PPK.

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Expression of Distinct Desmocollin Isoforms in Human Epidermis

Cited by 32 publications

References 39 publications

Discriminating roles of desmosomal cadherins: Beyond desmosomal adhesion

Discriminating roles of desmosomal cadherins: Beyond desmosomal adhesion

Epidermal desquamation

Acquired palmoplantar keratoderma and immunobullous disease associated with antibodies to desmocollin 3

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