Expression of discoidin domain receptor 1 and E‐cadherin in epidermis affects melanocyte behavior in rhododendrol‐induced leukoderma mouse model

Abe, Yuko; Hozumi, Yasukazu; Okamura, Ken; Suzuki, Tamio

doi:10.1111/1346-8138.15534

Cited by 5 publications

(3 citation statements)

References 13 publications

(33 reference statements)

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“…In the present report, skin pigmentation accompanied with an increase in the number of epidermal melanocytes surprisingly occurred in skin irradiated with a lower dose of MEL in RD-treated guinea pigs, when compared with control animals. It was reported that the application of RD-induced melanocyte cell death and temporarily reduced the expressions of E-cadherin and DDR1, inducing melanocyte floating in a tyrosinase-dependent manner in mice [ 45 , 46 ]. In our previous report, the number of DOPA-positive melanocytes was greatly reduced by applying RD to guinea pigs [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

A Lower Irradiation Dose of 308 nm Monochromatic Excimer Light Might Be Sufficient for Vitiligo Treatment: A Novel Insight Gained from In Vitro and In Vivo Analyses

Kuroda

Yang

Lai

et al. 2021

IJMS

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A 308 nm monochromatic excimer light (MEL) is widely used to treat patients with vitiligo. However, dose optimization still needs to be clarified. This study aimed to obtain objective evidence regarding various doses of MEL irradiation, induced cell level changes in vitro, and skin level alterations in vivo. Cultured human keratinocytes were irradiated with MEL using various doses. After irradiation at low doses, stem cell factor, endothelin-1, and glycoprotein nonmetastatic melanoma protein B, factors that activate and protect melanocytes, were found to be significantly elevated in keratinocytes. After irradiation using medium and high doses, inflammatory cytokines were induced. The amount of ATP released and the level of inflammasome activation, which are known to be related to interleukin-1β activation, were also increased. The back skin of guinea pigs and mice were irradiated with MEL at varying doses. After irradiation, an increase of epidermal melanin and epidermal melanocytes was confirmed, using the minimal erythemal dose or less. In rhododendrol-induced leukoderma guinea pigs, a much lower dose of MEL irradiation was effective, when compared with the effective dose for control guinea pigs. Our results suggest that a lower irradiation dose of MEL might be sufficient and more suitable for repigmentation in vitiligo treatment.

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Section: Discussionmentioning

confidence: 99%

A Lower Irradiation Dose of 308 nm Monochromatic Excimer Light Might Be Sufficient for Vitiligo Treatment: A Novel Insight Gained from In Vitro and In Vivo Analyses

Kuroda

Yang

Lai

et al. 2021

IJMS

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“…Discoidin domain receptor 1 (DDR1) forms complexes with E-cadherin [77] and acts as a collagen IV adhesion receptor, thereby regulating the location of melanocytes at the basement membrane zone [78]. As genetic variants of the DDR1 gene are observed in Brazilian [79] and Korean [80] populations, dysfunction of DDR1 may be associated with vitiligo pathogenesis, although further functional analysis is necessary [81]. Bastonini et al also summarizes the involvement of keratinocytes, fibroblasts, and the extracellular matrix in vitiligo pathogenesis [82].…”

Section: Pathogenesis Of Vitiligomentioning

confidence: 99%

Pathogenesis of Alopecia Areata and Vitiligo: Commonalities and Differences

Yamaguchi,

Peeva

2024

IJMS

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Both alopecia areata (AA) and vitiligo are distinct, heterogenous, and complex disease entities, characterized by nonscarring scalp terminal hair loss and skin pigment loss, respectively. In AA, inflammatory cell infiltrates are in the deep reticular dermis close to the hair bulb (swarm of bees), whereas in vitiligo the inflammatory infiltrates are in the epidermis and papillary dermis. Immune privilege collapse has been extensively investigated in AA pathogenesis, including the suppression of immunomodulatory factors (e.g., transforming growth factor-β (TGF-β), programmed death-ligand 1 (PDL1), interleukin-10 (IL-10), α-melanocyte-stimulating hormone (α-MSH), and macrophage migration inhibitory factor (MIF)) and enhanced expression of the major histocompatibility complex (MHC) throughout hair follicles. However, immune privilege collapse in vitiligo remains less explored. Both AA and vitiligo are autoimmune diseases that share commonalities in pathogenesis, including the involvement of plasmacytoid dendritic cells (and interferon-α (IFN- α) signaling pathways) and cytotoxic CD8+ T lymphocytes (and activated IFN-γ signaling pathways). Blood chemokine C-X-C motif ligand 9 (CXCL9) and CXCL10 are elevated in both diseases. Common factors that contribute to AA and vitiligo include oxidative stress, autophagy, type 2 cytokines, and the Wnt/β-catenin pathway (e.g., dickkopf 1 (DKK1)). Here, we summarize the commonalities and differences between AA and vitiligo, focusing on their pathogenesis.

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“…54,55 Both E-cadherin and DDR1 expression in keratinocytes resumed after disappearance of damaged melanocytes from the epidermis. 56 The weaker expression of E-cadherin and DDR1 adhering melanocytes to the epidermis basal layer has been implicated as one of the aggravating factors in the loss of melanocytes in vitiligo. It is quite possible that injured melanocytes affect the surrounding keratinocytes, subsequently altering the adhesion molecules.…”

Section: Epithelial Cadherin and Discoidin Domain Receptor Tyrosine K...mentioning

confidence: 99%

Surgical procedures and innovative approaches for vitiligo regenerative treatment and melanocytorrhagy

Kawakami

2022

The Journal of Dermatology

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Surgical treatments for vitiligo are a safe and effective treatment modality for select patients with vitiligo. Many techniques of vitiligo surgery exist, each with unique advantages and disadvantages. We reviewed the various surgical therapies and innovative approaches for vitiligo regenerative treatment reported in the literature. Surgical therapies can be subdivided into tissue grafting methods and cellular grafting methods. Tissue grafting methods mainly include mini punch grafts, suction blister roof grafts, and hair follicle grafts. Cellular grafting methods include cultured and non-cultured treatments. The efficacy needs to be improved largely due to the poor proliferation and quality of the autologous melanocytes. Rho-associated protein kinase inhibitor enhances primary melanocyte culture proliferation from vitiligo patients to prevent apoptosis. Innovative approaches using stem cell methods could prove invaluable in developing a novel cell therapy for patients suffering from vitiligo. We succeeded in inducing melanin pigmentation in mice skin in vivo using our human induced pluripotent stem cell-derived melanocytes. In addition, we reviewed melanocytorrhagy, detachment and transepidermal loss of melanocytes, and melanocyte-related adhesion molecules. These adhesion molecules include epithelial cadherin, discoidin domain receptor tyrosine kinase 1, glycoprotein non-metastatic melanoma protein B, macrophage migration inhibiting factor, 17β-hydroxysteroid dehydrogenase 1, and E26 transformation-specific 1.

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Expression of discoidin domain receptor 1 and E‐cadherin in epidermis affects melanocyte behavior in rhododendrol‐induced leukoderma mouse model

Cited by 5 publications

References 13 publications

A Lower Irradiation Dose of 308 nm Monochromatic Excimer Light Might Be Sufficient for Vitiligo Treatment: A Novel Insight Gained from In Vitro and In Vivo Analyses

A Lower Irradiation Dose of 308 nm Monochromatic Excimer Light Might Be Sufficient for Vitiligo Treatment: A Novel Insight Gained from In Vitro and In Vivo Analyses

Pathogenesis of Alopecia Areata and Vitiligo: Commonalities and Differences

Surgical procedures and innovative approaches for vitiligo regenerative treatment and melanocytorrhagy

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