Abstract:The expression of different immunological markers by cultured human melanocytes (MC) in relation to immune phenomena, were investigated on ten different MC cell lines from early (1st) to late (22nd) passage. Four melanocyte lines (MC-a) which had undergone changes in growth behaviour during prolonged culture were included in the study, together with two melanoma lines. Cytospin preparations of the cells were stained for the presence of a set of different immunological markers and a melanoma-associated antigen … Show more
“…Some melanocyte cell lines also express major histocompatibility complex class II molecules (Smit et al, 1993). Intercellular adhesion molecules such as intercellular adhesion molecule 1 (ICAM-1) and CD40 have also been shown to be expressed by melanocytes (Yohn et al, 1990;Lu et al, 2002).…”
Section: Immunity-associated Markers and Molecules On Melanocytesmentioning
“…Some melanocyte cell lines also express major histocompatibility complex class II molecules (Smit et al, 1993). Intercellular adhesion molecules such as intercellular adhesion molecule 1 (ICAM-1) and CD40 have also been shown to be expressed by melanocytes (Yohn et al, 1990;Lu et al, 2002).…”
Section: Immunity-associated Markers and Molecules On Melanocytesmentioning
“…After all, melanocytes produce cytokines that draw attention to themselves (5,6). They can phagocytize, and can process and present antigens in the context of MHC class II as one would normally expect a professional antigen-presenting cell to do (7,8).…”
Section: Viewpointmentioning
confidence: 99%
“…Metabolic damage, characterized by increased susceptibility to chemical ⁄ physical stress, high H 2 O 2 intracellular level, low catalase activity, faulty activity of the mitochondrial respiratory chain and defective assembly ⁄ activity of TRP1, all have been demonstrated (6)(7)(8)(9)(10)(11). The increased cellular death cannot be a simple effect of the in vitro manipulation, but mirror the in vivo experience of the Koëbner phenomenon.…”
“…Melanocytes can express major histocompatibility complex (MHC)-class I and II molecules and adhesion molecules, such as intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 (al Badri et al, 1993;Le Poole et al, 1993a;Smit et al, 1993). In addition, they can produce several cytokines, such as interleukin (IL)-1, IL-6 (Smit et al, 1993), IL-8 (Zachariae et al, 1991), and transforming growth factor-1 (TGF-1) (Le Poole and Boyce, 1999). Furthermore, melanocytes are not only capable of phagocytosis (Le Poole et al, 1993c), but can also process antigen and present antigenic peptides to T cells (Le Poole et al, 1993a).…”
Section: Ontogeny and Function Of Normal Human Melanocytesmentioning
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