Expression of dendritic cells in ovarian tumors correlates with clinical outcome in patients with ovarian cancer

Eisenthal, Avi; Polyvkin, N.; Bramante-Schreiber, Letizia; Misonznik, F.; Hassner, Avi; Lifschitz-Mercer, Beatriz

doi:10.1053/hupa.2001.26455

Cited by 60 publications

(44 citation statements)

References 18 publications

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“…Cases with more number of tumor infiltrating lymphocytes did not have the higher 5-year tumor-free survival rate compared to those with less infiltrating lymphocytes (Qin et al 1997), which might attribute to immunosuppression of the lymphocytes (Unitt et al 2005). The relationship between the number of tumor infiltrating DCs and clinicopathological features has been studied in esophageal (Ishigami et al 2003), lung (Zeid et al 1993), breast (Lespagnard et al 1999), cervical (Bethwaite et al 1996) and ovarian cancer (Eisenthal et al 2001). Most of these studies demonstrated that the number of tumor infiltrating DCs positively correlate with the clinicopathological features including surgical outcome, and even could serve as an independent prognostic factor in some cancers (Bethwaite et al 1996;Ishigami et al 2003).…”

Section: Discussionmentioning

confidence: 96%

“…Although the local immune responses cannot directly reflect the anti-tumor activity of immunocompetent cells in patients with tumor, it is of great significance in (Kawata et al 1992;Eisenthal et al 2001;Yu et al 2002;Dave et al 2004). Due to the complexity of the immune microenvironment, there is still controversy in the anti-tumor immune response of its single component; however, the interaction among its components that might heavily contribute to anti-tumor immune responses is gaining attention (Cho et al 2003).…”

Section: Discussionmentioning

confidence: 98%

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Dendritic cell infiltration and prognosis of human hepatocellular carcinoma

Cai

Gao

Qiu

et al. 2006

J Cancer Res Clin Oncol

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 98%

Dendritic cell infiltration and prognosis of human hepatocellular carcinoma

Cai

Gao

Qiu

et al. 2006

J Cancer Res Clin Oncol

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“…In addition, the correlation between increased CD8 + T-cell infiltration and good clinical outcome was recently described in the previous unstudied neoplasias, including GIST (Rusakiewicz et al, 2013), oropharyngeal ( Jung et al, 2013;Näsman et al, 2012;Wansom et al, 2012), thyroid (Cunha et al, 2012), and biliary tract cancer (Goeppert et al, 2013). Poor (Salvesen & Akslen, 1999) Good Poor (Lan et al, 2013) Good (Eisenthal et al, 2001;Zhang et al, 2015) Good Sato et al, 2005;Zhang et al, 2003) Oesophageal cancer -Poor (Guo et al, 2007) Poor (Shigeoka et al, 2013) Good (Furihata et al, 1992;Ishigami et al, 2003aIshigami et al, , 2003bLu et al, 2013) Good (Hsia et al, 2005) Colorectal cancer Good (Bindea et al, 2013;Menon et al, 2004) Poor (BarberaGuillem et al,…”

Section: Role Of T Cellsmentioning

confidence: 90%

Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of Cancers

Becht¹,

Giraldo²,

Germain³

et al. 2016

Advances in Immunology

177

136

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“…Tumor-infiltrating mature DC have also been observed in many solid tumors like melanoma [23,24], breast [25], gall bladder [26], and colorectal carcinomas [27]. Furthermore, although tumorspecific immune responsiveness is now regarded as an important mechanism that controls early-stage tumor growth and metastasis, the prognostic value of tumorinfiltrating DC is still controversial [28][29][30].…”

mentioning

confidence: 98%

Tumor microenvironment is multifaceted

Sautès-Fridman

Cherfils‐Vicini

Damotte

et al. 2011

Cancer Metastasis Rev

101

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Cancer initiation, progression, and invasion occur in a complex and dynamic microenvironment which depends on the hosts and sites where tumors develop. Tumors arising in mucosal tissues may progress in an inflammatory context linked to local viral and/or bacterial infections. At the opposite, tumors developing in immunoprivileged sites are protected from microorganisms and grow in an immunosuppressive environment. In the present review, we summarize and present our recent data on the influence of infectious context and immune cell infiltration organization in human Non-Small Cell Lung Cancers (NSCLC) progression. We show that stimulation of tumor cells by TLR for viral ssRNA, such as TLR7/8, or bacteria, such as TLR4, promotes cell survival and induces chemoresistance. On the opposite, stimulation by TLR3, receptor for double-stranded viral RNA, decreases tumor cell viability and induces chemosensitivity in some lung tumor cell lines. Since fresh lung tumor cells exhibit a gene expression profile characteristic of TLR-stimulated lung tumor cell lines, we suspect that viral and bacterial influence may not only act on the host immune system but also directly on tumor growth and sensitivity to chemotherapy. The stroma of NSCLC contains tertiary lymphoid structures (or Tumor-induced Bronchus-Associated Lymphoid Tissues (Ti-BALT)) with mature DC, follicular DC, and T and B cells. Two subsets of immature DC, Langerhans cells (LC) and interstitial DC (intDC), were detected in the tumor nests and the stroma, respectively. Here, we show that the densities of the three DC subsets, mature DC, LC, and intDC, are highly predictive of disease-specific survival in a series of 74 early-stage NSCLC patients. We hypothesize that the mature DC may derive from local activation and migration of the immature DC--and especially LC which contact the tumor cells--to the tertiary lymphoid structures, after sampling and processing of the tumor antigens. In view of the prominent role of DC in the immune response, we suggest that the microenvironment of early-stage NSCLC may allow the in situ activation of the adaptive response. Finally, we find that the eyes or brain of mice with growing B cell lymphoma are infiltrated with T cells and that the cytokines produced ex vivo by the tumoral tissues have an impaired Th1 cytokine profile. Our work illustrates that the host and external tumor microenvironments are multifaceted and strongly influence tumor progression and anti-tumor immune responses.

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Expression of dendritic cells in ovarian tumors correlates with clinical outcome in patients with ovarian cancer

Cited by 60 publications

References 18 publications

Dendritic cell infiltration and prognosis of human hepatocellular carcinoma

Dendritic cell infiltration and prognosis of human hepatocellular carcinoma

Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of Cancers

Tumor microenvironment is multifaceted

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