Expression of Decorin and Biglycan in Rat Gastric Tissue: Effects of Ulceration and Basic Fibroblast Growth Factor

Pohle, Thorsten; Altenburger, Martin; Shahin, Manal; Konturek, J. W.; Kresse, Hans; Domschke, W

doi:10.1080/003655201300191932

Cited by 6 publications

(5 citation statements)

References 35 publications

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“…Thus, decorin may suppress the proliferation of HCC through direct and indirect tumor inhibitory effects and may be associated with prognosis in patients with HCC ( Figure 3). However, decorin is known to be expressed not only in skeletal muscle [15], but also in various tissues including intestinal tissue, cardiac tissue, and adipose tissue [21][22][23][24]. Accordingly, it remains unclear where decorin comes from in the present study (Figure 3).…”

Section: Discussionmentioning

confidence: 76%

“…Decorin is also reported to interact with transforming growth factor-β and receptors of tyrosine kinase such as epidermal and insulin-like growth factors [17], leading to suppression of proliferation of various tumor cell lines, including HCC cell lines [18][19][20]. In addition, decorin is known to be expressed in various tissues including intestinal tissue, cardiac tissue, and adipose tissue and is known to regulate autophagy, inflammation, and glucose homeostasis [21][22][23][24]. Thus, accumulated evidence from basic studies suggests that decorin has an impact on the prognosis of patients with HCC.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Decorin on the Physical Function and Prognosis of Patients with Hepatocellular Carcinoma

Kawaguchi

Yoshio

Sakamoto

et al. 2020

JCM

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The outcome of patients with hepatocellular carcinoma (HCC) is still poor. Decorin is a small leucine-rich proteoglycan, which exerts antiproliferative and antiangiogenic properties in vitro. We aimed to investigate the associations of decorin with physical function and prognosis in patients with HCC. We enrolled 65 patients with HCC treated with transcatheter arterial chemoembolization (median age, 75 years; female/male, 25/40). Serum decorin levels were measured using enzyme-linked immunosorbent assays; patients were classified into the High or Low decorin groups by median levels. Associations of decorin with physical function and prognosis were evaluated by multivariate correlation and Cox regression analyses, respectively. Age and skeletal muscle indices were not significantly different between the High and Low decorin groups. In the High decorin group, the 6-min walking distance was significantly longer than the Low decorin group and was significantly correlated with serum decorin levels (r = 0.2927, p = 0.0353). In multivariate analysis, the High decorin group was independently associated with overall survival (hazard ratio 2.808, 95% confidence interval 1.016–8.018, p = 0.0498). In the High decorin group, overall survival rate was significantly higher than in the Low decorin group (median 732 days vs. 463 days, p = 0.010). In conclusion, decorin may be associated with physical function and prognosis in patients with HCC.

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Section: Discussionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Impact of Decorin on the Physical Function and Prognosis of Patients with Hepatocellular Carcinoma

Kawaguchi

Yoshio

Sakamoto

et al. 2020

JCM

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“…DS binds to apoptotic cells and autoAgs released from dying cells, which has led to our previous identification of hundreds of autoAgs ( 13–16, 18 ). Upon tissue injury, DS biosynthesis is ramped up by fibroblasts and epithelial and endothelial cells ( 7–9 ). After tissue injury, DS assists fibroblast migration into the wound to facilitate granulation tissue formation and wound healing ( 11 ).…”

Section: Resultsmentioning

confidence: 99%

An Autoantigen Atlas from Human Lung HFL1 Cells Offers Clues to Neurological and Diverse Autoimmune Manifestations of COVID-19

Wang¹,

Zhang

Mw³

et al. 2021

Preprint

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COVID-19 is accompanied by a myriad of both transient and long-lasting autoimmune responses. Dermatan sulfate (DS), a glycosaminoglycan crucial for wound healing, has unique affinity for autoantigens (autoAgs) from apoptotic cells. DS-autoAg complexes are capable of stimulating autoreactive B cells and autoantibody production. Using DS affinity, we identified an autoantigenome of 408 proteins from human fetal lung fibroblast HFL11 cells, at least 231 of which are known autoAgs. Comparing with available COVID data, 352 proteins of the autoantigenome have thus far been found to be altered at protein or RNA levels in SARS-Cov-2 infection, 210 of which are known autoAgs. The COVID-altered proteins are significantly associated with RNA metabolism, translation, vesicles and vesicle transport, cell death, supramolecular fibrils, cytoskeleton, extracellular matrix, and interleukin signaling. They offer clues to neurological problems, fibrosis, smooth muscle dysfunction, and thrombosis. In particular, 150 altered proteins are related to the nervous system, including axon, myelin sheath, neuron projection, neuronal cell body, and olfactory bulb. An association with the melanosome is also identified. The findings from our study illustrate a strong connection between viral infection and autoimmunity. The vast number of COVID-altered proteins with propensity to become autoAgs offers an explanation for the diverse autoimmune complications in COVID patients. The variety of autoAgs related to mRNA metabolism, translation, and vesicles raises concerns about potential adverse effects of mRNA vaccines. The COVID autoantigen atlas we are establishing provides a detailed molecular map for further investigation of autoimmune sequelae of the pandemic.Summary sentenceAn autoantigenome by dermatan sulfate affinity from human lung HFL1 cells may explain neurological and autoimmune manifestations of COVID-19

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“…DS binds to apoptotic cells and autoAgs released from dying cells, which has led to our previous identification of hundreds of autoAgs ( 13 – 16 , 18 ). Upon tissue injury, DS biosynthesis is ramped up by fibroblasts and epithelial and endothelial cells ( 7 – 9 ). After tissue injury, DS assists fibroblast migration into the wound to facilitate granulation tissue formation and wound healing ( 11 ).…”

Section: Resultsmentioning

confidence: 99%

“…In human wound fluid, DS is the most abundant glycosaminoglycan ( 6 ). Its biosynthesis is increased by fibroblasts, epithelial cells, and capillary endothelial cells in wounded skin, mucosal ulcers, and inflammation-associated angiogenesis ( 7 – 9 ). Its molecular size also changes during wound healing, with elongated DS polymers packing along thin collagen fibrils in wounded skin ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

An Autoantigen Atlas From Human Lung HFL1 Cells Offers Clues to Neurological and Diverse Autoimmune Manifestations of COVID-19

Wang¹,

Zhang

Roehrl³

et al. 2022

Front. Immunol.

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COVID-19 is accompanied by a myriad of both transient and long-lasting autoimmune responses. Dermatan sulfate (DS), a glycosaminoglycan crucial for wound healing, has unique affinity for autoantigens (autoAgs) from apoptotic cells. DS-autoAg complexes are capable of stimulating autoreactive B cells and autoantibody production. We used DS-affinity proteomics to define the autoantigen-ome of lung fibroblasts and bioinformatics analyses to study the relationship between autoantigenic proteins and COVID-induced alterations. Using DS-affinity, we identified an autoantigen-ome of 408 proteins from human HFL1 cells, at least 231 of which are known autoAgs. Comparing with available COVID data, 352 proteins of the autoantigen-ome have thus far been found to be altered at protein or RNA levels in SARS-CoV-2 infection, 210 of which are known autoAgs. The COVID-altered proteins are significantly associated with RNA metabolism, translation, vesicles and vesicle transport, cell death, supramolecular fibrils, cytoskeleton, extracellular matrix, and interleukin signaling. They offer clues to neurological problems, fibrosis, smooth muscle dysfunction, and thrombosis. In particular, 150 altered proteins are related to the nervous system, including axon, myelin sheath, neuron projection, neuronal cell body, and olfactory bulb. An association with the melanosome is also identified. The findings from our study illustrate a connection between COVID infection and autoimmunity. The vast number of COVID-altered proteins with high intrinsic propensity to become autoAgs offers an explanation for the diverse autoimmune complications in COVID patients. The variety of autoAgs related to mRNA metabolism, translation, and vesicles suggests a need for long-term monitoring of autoimmunity in COVID. The COVID autoantigen atlas we are establishing provides a detailed molecular map for further investigation of autoimmune sequelae of the pandemic, such as “long COVID” syndrome.Summary SentenceAn autoantigen-ome by dermatan sulfate affinity from human lung HFL1 cells may explain neurological and autoimmune manifestations of COVID-19.

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Expression of Decorin and Biglycan in Rat Gastric Tissue: Effects of Ulceration and Basic Fibroblast Growth Factor

Abstract: The expression of decorin could be observed for the first time in epithelial cells. Decorin, but not biglycan, appears as an early phase reactant in the muscularis mucosae in accordance with its putative role during angiogenesis and the prevention of apoptosis.

Cited by 6 publications

References 35 publications

Impact of Decorin on the Physical Function and Prognosis of Patients with Hepatocellular Carcinoma

Impact of Decorin on the Physical Function and Prognosis of Patients with Hepatocellular Carcinoma

An Autoantigen Atlas from Human Lung HFL1 Cells Offers Clues to Neurological and Diverse Autoimmune Manifestations of COVID-19

An Autoantigen Atlas From Human Lung HFL1 Cells Offers Clues to Neurological and Diverse Autoimmune Manifestations of COVID-19

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