Expression of cyclooxygenase isoforms in ulcerated tissues of the nonglandular portion of the stomach in horses

Rodrigues, N.; Doré, Monique; Doucet, Michèle

doi:10.2460/ajvr.71.5.592

Cited by 8 publications

(5 citation statements)

References 37 publications

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“…However, this study was performed on cultured cells and it is unknown if this is applicable to ulcerated gastric mucosa in horses. Overall, these findings suggest a possible role for COX‐2 in mucosal repair, indicating that horses with gastric ulceration should remain off NSAIDs regardless of their selectivity.…”

Section: Side Effectsmentioning

confidence: 81%

The use of nonsteroidal anti‐inflammatory drugs in critically ill horses

Cook

Blikslager

2014

J Vet Emergen Crit Care

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Section: Side Effectsmentioning

confidence: 81%

The use of nonsteroidal anti‐inflammatory drugs in critically ill horses

Cook

Blikslager

2014

J Vet Emergen Crit Care

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“…Gastrointestinal ulceration associated with NSAID administration in horses and other species likely occurs owing to interference with mucosal protective mechanisms. In vitro and ex vivo studies have demonstrated that COX1 is preferentially expressed in the healthy gastric mucosa of horses and COX2 is variably expressed in healing ulcers in this region, or induced after bradykinin stimulation of tissue explants . Hence it has been hypothesized that agents such as meloxicam, which preferentially targets COX2 in horses, might spare COX1 and hence have less detrimental effect on gastric mucosal integrity than nonselective NSAIDs such as phenylbutazone (PBZ).…”

Section: Introductionmentioning

confidence: 99%

Effects of Meloxicam and Phenylbutazone on Equine Gastric Mucosal Permeability

D'Arcy-Moskwa

Noble

Weston

et al. 2012

Veterinary Internal Medicne

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Background: Newer NSAIDs that more selectively target the induced isoform of the cyclooxygenase enzyme (COX2) activity might reduce adverse effects while preserving therapeutic benefits of these drugs.Objectives: To compare the effect of oral administration of multiple dose rates of meloxicam and phenylbutazone (PBZ) on gastric mucosal integrity in horses.Animals: Twenty-five light breed horses. Methods: In vivo toxicity study. Horses were randomly assigned to 5 treatment groups, receiving placebo, PBZ (4.4 mg/kg PO q12h day 1, 2.2 mg/kg PO q12h for 4 days, 2.2 mg/kg PO q24h for 9 days), or 3 dose rates of meloxicam (0.6 mg/kg q24h, 1.8 mg/kg q24h, 3.0 mg/kg q24h) for 14 days. Sucrose permeability testing was performed on Day 0 (before treatment) and on Day 13. All personnel involved with data collection or analysis were blinded to treatment.Results: Administration of PBZ at the above dose rate significantly increased gastric permeability to sucrose, evidenced by increased peak serum sucrose concentrations (280-1,580 pg/lL, P = .001) after treatment. Similar changes were not evident after administration of meloxicam at any dose rate tested, or in control horses (P > .05). Treatment was not associated with significant differences in ulceration of the squamous or glandular mucosa. Peak sucrose concentrations were not correlated with serum total protein or albumin concentrations (R 2 = À0.07, P = .61, R 2 = À0.08, P = .58, respectively). Conclusion and Clinical Importance: These results suggest that PBZ was associated with greater compromise to gastric mucosal integrity than meloxicam.

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“…COX-1 enzymes have been found in healthy, non-ulcerated, squamous gastric mucosa in horses, with little expression of COX-2 isoforms [ 70 ]. However, in the presence of ulcerated lesions, it was found that expression of COX-2 enzymes was significantly increased.…”

Section: Pathologymentioning

confidence: 99%

“…However, in the presence of ulcerated lesions, it was found that expression of COX-2 enzymes was significantly increased. COX-2 enzymes may have an important role in the mucosal healing of squamous gastric ulcerations in horses and further research is required to assess the clinical relevance and potential effects of COX-2 selective NSAIDs on the healing of gastric ulcers [ 70 ]. A study comparing meloxicam (0.6–3.0 mg/kg PO) and phenylbutazone (4.4 mg/kg PO q12 h day 1, 2.2 mg/kg PO q12 h for 4 days, 2.2 mg/kg PO q24 h for 9 days) found that phenylbutazone administration resulted in increased gastric mucosal permeability to sucrose, suggesting phenylbutazone may be associated with increased mucosal damage in comparison to meloxicam [ 71 ].…”

Section: Pathologymentioning

confidence: 99%

Non-Steroidal Anti-Inflammatory Drugs and Associated Toxicities in Horses

Flood

Stewart

2022

Animals

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Effective pain management in horses can be a challenge despite the understanding that appropriate analgesia improves animal welfare and increases treatment success. The administration of NSAID drugs, particularly phenylbutazone and flunixin, are common practice in equine veterinary patients. Known for their analgesic and anti-inflammatory properties, NSAIDs are used for the treatment of a variety of conditions in horses, from gastrointestinal to orthopedic pain. Despite extensive usage, NSAIDs have a narrow margin of safety and the body of literature documenting the efficacy and side effects of different NSAIDs is broad. The three main side effects associated with excessive or prolonged NSAID usage in horses include gastroduodenal ulceration, right dorsal colitis (RDC) and renal papillary necrosis. The use of cyclooxygenase-2 selective NSAIDS, such as firocoxib, are theoretically safer. The aim of this paper is to review the current literature on the use and efficacy of different NSAIDs, summarise the associated side effects of NSAID usage and evaluate the current state of knowledge for the diagnosis and treatment of such toxicities.

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Expression of cyclooxygenase isoforms in ulcerated tissues of the nonglandular portion of the stomach in horses

Abstract: Increased expression of COX-2 in gastric ulcers of the squamous portion of the stomach in horses suggested a role for this enzyme in gastric ulcer healing.

Cited by 8 publications

References 37 publications

The use of nonsteroidal anti‐inflammatory drugs in critically ill horses

The use of nonsteroidal anti‐inflammatory drugs in critically ill horses

Effects of Meloxicam and Phenylbutazone on Equine Gastric Mucosal Permeability

Non-Steroidal Anti-Inflammatory Drugs and Associated Toxicities in Horses

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