Expression of Cyclon/CCDC86, a novel nuclear protein, in the hippocampus of adult non-human primates

Shishkov, Rinaldo; Chervenkov, Trifon; Yamashima, Tetsumori; Tonchev, Anton B.

doi:10.1016/j.jneuroim.2013.02.016

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…SARS-CoV-2 could also utilize these or similar groups of proteins for its effective shuttling between various subcellular compartments. Although AP2M1 and UBE2I were discussed earlier, CCDC86, an important cytokine-induced protein that regulates various immune responses, was shown to be expressed in the hippocampus of adult macaque monkeys, indicating the importance of this CSP in neurological disorders during COVID-19 ( Shishkov et al., 2013 ). RAB and RHO group of ras proteins may be involved in augmenting inflammatory signaling pathways ( Prashar et al., 2017 ).…”

Section: Discussionmentioning

confidence: 97%

Integrative Network Biology Framework Elucidates Molecular Mechanisms of SARS-CoV-2 Pathogenesis

et al. 2020

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COVID-19 (coronavirus disease 2019) is a respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although the pathophysiology of this virus is complex and largely unknown, we employed a network-biology-fueled approach and integrated transcriptome data pertaining to lung epithelial cells with human interactome to generate Calu-3-specific human-SARS-CoV-2 interactome (CSI). Topological clustering and pathway enrichment analysis show that SARS-CoV-2 targets central nodes of the host-viral network, which participate in core functional pathways. Network centrality analyses discover 33 high-value SARS-CoV-2 targets, which are possibly involved in viral entry, proliferation, and survival to establish infection and facilitate disease progression. Our probabilistic modeling framework elucidates critical regulatory circuitry and molecular events pertinent to COVID-19, particularly the host-modifying responses and cytokine storm. Overall, our network-centric analyses reveal novel molecular components, uncover structural and functional modules, and provide molecular insights into the pathogenicity of SARS-CoV-2 that may help foster effective therapeutic design.

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Section: Discussionmentioning

confidence: 97%

Integrative Network Biology Framework Elucidates Molecular Mechanisms of SARS-CoV-2 Pathogenesis

et al. 2020

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“…Coiled-coil domains constitute a family of proteins containing coiled-coil domains (CCDCs), which are involved in many functions in cell growth and development, such as regulation of gene expression and drug sensitivity [10][11][12][13][14][15]. The abnormal expression of CCDC65 and CCDC88 proteins has been shown to significantly affect the malignant progression of gastric and pancreatic cancers, providing a theoretical basis for identifying oncology drug targets.…”

Section: Introductionmentioning

confidence: 99%

Coiled-Coil Domain-Containing Protein 45 Is a Potential Prognostic Biomarker and Is Associated with Immune Cell Enrichment of Hepatocellular Carcinoma

et al. 2022

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Objective. The role of coiled-coil domain-containing protein 45 (CCDC45) in the development of hepatocellular carcinoma (HCC) has not been reported. The present study is aimed at investigating the expression and prognosis of CCDC45 in HCC and its relevance to immune infiltration. Methods. We conducted CCDC45 expression analysis using The Cancer Genome Atlas (TCGA) tumor database, the Human Protein Atlas (HPA) database, and the Tumor Immunological Evaluation Resource (TIMER). We used the University of Alabama at Birmingham Cancer data analysis Portal (UALCAN) database to show the correlation of CCDC45 with clinical features. We examined the prognostic impact of CCDC45 expression levels on HCC patients with the Kaplan-Meier mapper database. Genes coexpressed with CCDC45 and its regulators were also identified using LinkedOmics. The enriched Gene Ontology (GO) categories and associated signaling pathways were estimated using GO, Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Set Enrichment Assay (GSEA) pathway data. Correlations between CCDC45 and cancer immune infiltration was analyzed through the TIMER and an integrated repository portal for Tumor-Immune System Interactions (TISIDB) databases. Results. The expression of CCDC45 was elevated in HCC tissues compared to adjacent liver tissues, and overexpression of CCDC45 was significantly correlated with tumor stage. Furthermore, HCC patients with CCDC45 overexpression had a shorter overall survival (OS). Functional network analysis indicated that CCDC45 was involved in homologous recombination, spliceosome, and DNA replication. Interestingly, CCDC45 expression was positively correlated with the level of immune cell infiltration. Conclusions. CCDC45 is associated with prognosis and immune infiltration of HCC and may be a potential therapeutic target for HCC.

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Expression of Cyclon/CCDC86, a novel nuclear protein, in the hippocampus of adult non-human primates

Cited by 2 publications

References 17 publications

Integrative Network Biology Framework Elucidates Molecular Mechanisms of SARS-CoV-2 Pathogenesis

Integrative Network Biology Framework Elucidates Molecular Mechanisms of SARS-CoV-2 Pathogenesis

Coiled-Coil Domain-Containing Protein 45 Is a Potential Prognostic Biomarker and Is Associated with Immune Cell Enrichment of Hepatocellular Carcinoma

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