Expression of cyclins in gastric carcinoma and in the gastric mucosa of first-degree relatives

Miehlke, Stephan; Szokodi, Daniel; Yu, Jin; Eder, Matthias; Kuhlisch, Eberhard; Buchcik, Rene; Wehrmann, U.; Stolte, Manfred; Ehninger, Gerhard; Bayerdoerffer, Ekkehard

doi:10.1016/s0016-5085(00)85181-1

Cited by 6 publications

(14 citation statements)

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“…Analyses of cyclin D3 localization in other tumor types indicated that cyclin D3 expression is enhanced in renal and gastric tumors (Hedberg et al, 2002;Miehlke et al, 2002). In renal cancer, high cyclin D3 expression correlated with high proliferative indices, and was detected in both the nucleus and cytoplasm (Hedberg et al, 2002;Miehlke et al, 2002). These data are distinct from our observations where cyclin D3 expression was mainly localized to the cytoplasm and inversely correlated with tumor grade and Ki-67 index, indicating distinct roles for cyclin D3 activity in different tumor types.…”

Section: Cyclin D3 Expression Is Altered In Pca Progressioncontrasting

confidence: 93%

“…Total cyclin D3 expression is inversely correlated with Ki-67, whereas nuclear cyclin D1 corresponds with higher Ki-67. Analyses of cyclin D3 localization in other tumor types indicated that cyclin D3 expression is enhanced in renal and gastric tumors (Hedberg et al, 2002;Miehlke et al, 2002). In renal cancer, high cyclin D3 expression correlated with high proliferative indices, and was detected in both the nucleus and cytoplasm (Hedberg et al, 2002;Miehlke et al, 2002).…”

Section: Cyclin D3 Expression Is Altered In Pca Progressionmentioning

confidence: 99%

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Cyclin D3 action in androgen receptor regulation and prostate cancer

et al. 2007

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Prostate cancer (PCa) cell proliferation is dependent on activation of the androgen receptor (AR), a liganddependent transcription factor. AR activation controls G1-S phase progression through fostering enhanced translation of the D-type cyclins, which promote cell cycle progression through activation of CDK4/6. However, the D-type cyclins harbor additional, CDK4/6 kinase-independent, functions through manipulation of transcription factors, including AR. It was previously established that cyclins D1 and D3 have the potential to modulate AR, and with regard to cyclin D1, disruption of this function occurs in human tumors. Therefore, it was essential to interrogate cyclin D3 function in this tumor type. Here, we show that cyclin D3 is found in association with AR in PCa cells, as mediated through a conserved motif. Cyclin D3 functions to attenuate AR activity through defined mechanisms that include modulation of ligand-dependent conformational changes and modulation of chromatin binding activity. Accumulated cyclin D3 slows cell proliferation in AR-dependent cells, thus suggesting that androgen-induced D-type cyclin production serves to temper the mitogenic response to androgen. Supporting this hypothesis, it is shown that cyclin D3 expression is reduced in primary PCas as a function of tumor grade, and inversely correlates with the proliferative index. In total, these data identify cyclin D3 as a critical modulator of the androgen response, whose deregulation may foster unchecked AR activity in PCa.

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Section: Cyclin D3 Expression Is Altered In Pca Progressioncontrasting

confidence: 93%

Section: Cyclin D3 Expression Is Altered In Pca Progressionmentioning

confidence: 99%

Cyclin D3 action in androgen receptor regulation and prostate cancer

et al. 2007

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“…Different types of cyclins, alphabetically ordered, have been identified, and for some of these, particularly D1, D2, and E cyclins, the possible role in human carcinogenesis has been investigated [14,15]. On the contrary, there are not many studies regarding cyclin B1 and D3 expression in gastric cancer.…”

Section: Introductionmentioning

confidence: 99%

p27 downregulation and metallothionein overexpression in gastric cancer patients are associated with a poor survival rate

Galizia

Ferraraccio

Lieto

et al. 2006

Journal of Surgical Oncology

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“…The fact that first-degree relatives of gastric cancer patients have a significantly increased risk for developing gastric cancer compared to patients without a family history further emphasizes the importance of genetic factors. For example, our group found some important gastric cancer related genes to be more prevalent in the gastric mucosa of first-degree relatives [45][46][47][48][49] . The infection with H pylori trig gers an extensive systemic and local inflammator y response.…”

Section: Host Genetic Factorsmentioning

confidence: 99%

Eradication of H pylori for the prevention of gastric cancer

Trautmann¹,

Stolte²,

Miehlke³

2006

WJG

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Infection with H pylori is the most important known etiological factor associated with gastric cancer. While colonization of the gastric mucosa with H pylori results in active and chronic gastritis in virtually all individuals infected, the likelihood of developing gastric cancer depends on environmental, bacterial virulence and host specific factors. The majority of all gastric cancer cases are attributable to H pylori infection and therefore theoretically preventable. There is evidence from animal models that eradication of H pylori at an early time point can prevent gastric cancer development. However, randomized clinical trials exploring the prophylactic effect of H pylori eradication on the incidence of gastric cancer in humans remain sparse and have yielded conflicting results. Better markers for the identification of patients at risk for H pylori induced gastric malignancy are needed to allow the development of a more efficient public eradication strategy. Meanwhile, screening and treatment of H pylori in first-degree relatives of gastric cancer patients as well as certain high-risk populations might be beneficial.

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Expression of cyclins in gastric carcinoma and in the gastric mucosa of first-degree relatives

Cited by 6 publications

References 0 publications

Cyclin D3 action in androgen receptor regulation and prostate cancer

Cyclin D3 action in androgen receptor regulation and prostate cancer

p27 downregulation and metallothionein overexpression in gastric cancer patients are associated with a poor survival rate

Eradication of H pylori for the prevention of gastric cancer

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