Expression of CXCR6 and its ligand CXCL16 in the lung in health and disease

Morgan, Angela; Guillén, Cristina; Symon, F A; Huynh, Tam T.; Berry, Michael A.; Entwisle, James; Briskin, Michael; Pavord, Ian D.; Wardlaw, Andrew J.

doi:10.1111/j.1365-2222.2005.02383.x

Cited by 87 publications

(83 citation statements)

References 24 publications

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“…It has been shown that similar chemokine receptor expression profiles are found on BAL T cells from healthy controls and asthmatic subjects (27)(28)(29)(30)(31), so the increased expression of specific chemokine receptors on BAL T cells as compared with PB T cells is likely to be related to both an increase in memory T cells in the BAL as compared with PB and to the requirement for specific chemoattractant receptors in trafficking to the BAL and other tissue sites. In addition to the skin-associated (CCR4 and CCR10) and gut-associated (CCR9) chemoattractant receptors, certain receptors are enriched on tissue-localized T cells as compared with PB T cells, including but not limited to CXCR3, CXCR6, CCR5, and CCR6.…”

Section: Discussionmentioning

confidence: 80%

Multiple Chemokine Receptors, Including CCR6 and CXCR3, Regulate Antigen-Induced T Cell Homing to the Human Asthmatic Airway

Thomas

Banerji

Medoff

et al. 2007

The Journal of Immunology

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Human allergic asthma is a chronic inflammatory disease of the airways thought to be driven by allergen-specific Th2 cells, which are recruited into the lung in response to inhaled allergen. To identify chemoattractant receptors that control this homing pattern, we used endobronchial segmental allergen challenge in human atopic asthmatics to define the pattern of chemoattractant receptor expression on recruited T cells as well as the numbers of recruited CD1d-restricted NKT cells and levels of chemokines in the bronchoalveolar (BAL) fluid. CD1d-restricted NKT cells comprised only a small minority of BAL T cells before or after Ag challenge. BAL T cells were enriched in their expression of specific chemoattractant receptors compared with peripheral blood T cells prechallenge, including CCR5, CCR6, CXCR3, CXCR4, and BLT1. Surprisingly, following segmental allergen challenge, no chemoattractant receptor was specifically increased. However, CCR6 and CXCR3, which were expressed on virtually all CD4+ BAL T cells prechallenge, were markedly decreased on all recruited BAL T cells following Ag challenge, suggesting that these receptors were internalized following encounter with ligand in the airway. Our data therefore suggests a role for CCR6 and CXCR3, in conjunction with other chemoattractant receptors, in the recruitment of inflammatory T cells into the BAL during the allergic asthmatic response.

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Section: Discussionmentioning

confidence: 80%

Multiple Chemokine Receptors, Including CCR6 and CXCR3, Regulate Antigen-Induced T Cell Homing to the Human Asthmatic Airway

Thomas

Banerji

Medoff

et al. 2007

The Journal of Immunology

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“…These mice did not exhibit any obvious pathologies and, subsequently, they were used to investigate the function of CXCR6 in T-cell subsets. These studies led to the proposal that CXCR6 and its ligand CXCL16 play important roles in lung lymphocyte homing (36,37) and liver-based immune responses (38) although the precise mechanism of action is unclear. We observed our Cxcr6 mutant mice for a period of 12 months and made the surprising observation that a small number of both heterozygous and homozygous mice , n = 1; Cxcr6 À/À , n = 4) stained positive for both glial fibrillary acidic protein and synaptophysin (Fig.…”

Section: Resultsmentioning

confidence: 99%

Medulloblastomas Derived from Cxcr6 Mutant Mice Respond to Treatment with a Smoothened Inhibitor

et al. 2007

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“…CXCL16 has also been independently cloned and named SRPSOX (21). Moreover, CXCL16/CXCR6 signaling has been associated with liver-specific homing (19,(28)(29)(30) and lung-specific homing (31,32) in the events of inflammation. To our knowledge, this is the first report presenting evidence for the expression and function of both CXCL16 and CXCR6 in prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

CXCL16 Functions as a Novel Chemotactic Factor for Prostate Cancer Cells In vitro

Lü

Wang

et al. 2008

Molecular Cancer Research

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A variety of tumor cells produce chemokines that promote tumor cell proliferation and chemotaxis. We previously reported that CXCL16 production is increased in aggressive prostate cancer cells compared with the less aggressive tumor cells and benign cells as identified in a cytokine antibody array. The functional contribution of CXCL16 in prostate cancer development has not yet been evaluated. Accordingly, mRNA expression of CXCL16 and its receptor, CXCR6, were determined by real-time reverse transcription-PCR in various cancer cell lines, including prostate cancer and tissues obtained from localized and metastatic prostate cancer. Consistent with our finding on CXCL16 protein production by prostate cancer cells, aggressive prostate cancer C4-2B and PC3 cells, as well as bone and liver metastatic tissues, expressed higher levels of both CXCL16 and CXCR6 mRNA compared with the less aggressive prostate cancer LNCaP cells, nonneoplastic PrEC and RWPE-1 cells, and benign prostate tissues, respectively. Furthermore, CXCR6 and CXCL16 protein expressions were examined in tissue specimens by immunohistochemistry. Immunohistochemical examination of CXCR6 expression showed strong epithelial staining that correlated with Gleason score, whereas CXCL16 staining was not. Finally, we found that both interleukin-1B and tumor necrosis factor A significantly induced CXCL16 production by prostate epithelial cells, thereby indicating that inflammatory cytokines may play a role in the CXCL16 induction. CXCL16 was found to promote prostate cancer cell migration and invasion in vitro. Therefore, we concluded that CXCL16 functions, through CXCR6, as a novel chemotactic factor for prostate cancer cells.

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Expression of CXCR6 and its ligand CXCL16 in the lung in health and disease

Abstract: This data suggests that CXCR6 and CXCL16 may play a role in T cell recruitment to the lung.

Cited by 87 publications

References 24 publications

Multiple Chemokine Receptors, Including CCR6 and CXCR3, Regulate Antigen-Induced T Cell Homing to the Human Asthmatic Airway

Multiple Chemokine Receptors, Including CCR6 and CXCR3, Regulate Antigen-Induced T Cell Homing to the Human Asthmatic Airway

Medulloblastomas Derived from Cxcr6 Mutant Mice Respond to Treatment with a Smoothened Inhibitor

CXCL16 Functions as a Novel Chemotactic Factor for Prostate Cancer Cells In vitro

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