Expression of CRH, CRH-related peptide and CRH receptor in the ovary and potential CRH signalling pathways

Importance of adrenergic pathways in women's cancers

“…Activation of the SNS also stimulates the release of CRF by hypothalamic paraventricular nuclei. Thus, the stress-response system functions as a positive, bidirectional feedback loop: activation of one component of the system stimulates the other components at multiple levels [6, 10] . Centrally acting hypothalamic neuropeptide corticotropin-releasing hormone (CRH) inhibits hypothalamic gonadotropin-releasing hormone (GnRH) secretion, which in turn affects pituitary luteinizing hormone (LH) and follicular stimulating hormone (FSH) release and conversely inhibits gonadal estrogen (E) and progesterone (P) secretion.…”

“…Centrally acting hypothalamic neuropeptide corticotropin-releasing hormone (CRH) inhibits hypothalamic gonadotropin-releasing hormone (GnRH) secretion, which in turn affects pituitary luteinizing hormone (LH) and follicular stimulating hormone (FSH) release and conversely inhibits gonadal estrogen (E) and progesterone (P) secretion. Systemically, CRH and associated receptors have been identified in most female reproductive tissues, including the ovary and uterus where they are involved in reproductive function [10]. In addition, glucocorticoids secreted from the adrenal cortex in response to HPA activation also suppress the gonadal axis via receptors in the female reproductive system [11].…”

Effect of Intermittent Feeding on Gonadal Function in Male And Female NMRI Mice During Chronic Stress

“…Steroid hormones can pass through the blood-brain barrier, and affect processes such as neurogenesis, synaptogenesis, dendritic development, and apoptosis 6 . Studies have indicated the presence of CRH and its receptors in the reproductive system 7 . Also, glucocorticoids released from adrenal glands, due to stress, inhibit the production of testosterone in leydig cells 8 .…”

“…For instance, testosterone suppresses HPA axis 8 . On the contrary, estrogen reinforces this axis in many different ways 7 . The activity of gonadal-steroidal hormones, especially testosterone, modulates HPA activity, and thus prevents the harmful effects of HPA activity on the reproductive system function 12 .…”

Association analysis of polymorphisms of the CRHR1 gene with infantile spasms

“…The effect of CRH is mediated via CRH receptors in the cell membrane of effector organs (14). Two major CRH receptors, CRHR1 and CRHR2, have been identified and have functional differences between them (15).…”