Expression of Coxsackievirus and Adenovirus Receptor Isoforms in Developing Mouse Bladder Uroepithelium

Gye, Myung Chan; Oh, Yeong Seok; Lee, Jae Eun; Shim, Sarah; Choi, Kyung San; Ahn, Hyun Soo

doi:10.1016/j.urology.2010.11.005

Cited by 5 publications

(3 citation statements)

References 26 publications

(40 reference statements)

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“…Permanently mounted slides were observed and images were captured using a microscope (IX71, Olympus, Japan) equipped with a digital imaging system (DP71, Olympus). Quantitative imaging of ER␣ and ER␤ staining was conducted in four different sections using a commercially available image analysis program (IMT iSolution Lite, version 7.8, iMTechnology, Vancouver, British Columbia, Canada), according to the method described by Gye et al (2011).…”

Section: Immunohistochemistry and Image Analysismentioning

confidence: 99%

Sensitization of vitellogenin gene expression by low doses of octylphenol is mediated by estrogen receptor autoregulation in the Bombina orientalis (Boulenger) male liver

Park

Gye

2014

Aquatic Toxicology

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Section: Immunohistochemistry and Image Analysismentioning

confidence: 99%

Sensitization of vitellogenin gene expression by low doses of octylphenol is mediated by estrogen receptor autoregulation in the Bombina orientalis (Boulenger) male liver

Park

Gye

2014

Aquatic Toxicology

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“…In contrast, viral vector‐based gene delivery can avoid the need for frequent administration of short half‐life peptides, and the lack of off‐target activity suggests that this type of delivery can avoid systemic side‐effects that have also been observed using direct delivery of therapeutic protein(s) . The physiological barrier function of normal urothelial cells, which possess tight junctions and high epithelial resistance, can prevent effective passage and infection/transfer of genes; whereas, the efficiency of delivering a genetic payload to the target cell is higher compared with non‐viral systems, because over millennia, viruses have acquired effective methods to deliver their own genetic material to cells to replicate their genomes and further propagate themselves. However there are potential risks with viral vectors, such as endogenous viral recombination, cancer development and immunological reactions …”

Section: Gene Delivery Strategymentioning

confidence: 99%

Gene therapy for lower urinary tract dysfunction

et al. 2012

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Abbreviations & Acronyms AAV1 = adeno-associated virus type 1 BOO = bladder outlet obstruction DRG = dorsal root ganglion GABA = g-aminobutyric acid GAD = glutamic acid decarboxylase HGF = hepatocyte growth factor HSV = herpes simplex virus IC/BPS = interstitial cystitis/bladder pain syndrome IL = interleukin LUT = lower urinary tract LUTS = lower urinary tract symptoms MnSOD = manganese superoxide dismutase NGF = nerve growth factor POMC = pro-opiomelanocortin SERCA = sarco/endoplasmic reticulum calcium ATPase SR = sarco/endoplasmic reticulum SUI = stress urinary incontinence TNFa = tumor necrosis factor a TNFasR = tumor necrosis factor a soluble receptor Abstract: Lower urinary tract dysfunction is caused by functional and pathophysiological alterations of the peripheral organs, including the urothelium and detrusor smooth muscle, as well as peripheral and central nervous systems. Recent research in this field has increased our understanding of the mechanisms of lower urinary tract dysfunction, and new drugs have been developed, leading to increased treatment options and changing medical care for lower urinary tract symptoms. Nevertheless, clinicians still often experience refractory and treatment-resistant cases against conventional therapeutic modalities. For such cases, gene therapy targeting for the lower urinary tract and its afferent pathway is anticipated to offer a new therapeutic approach. Therefore, in this article, we review the possibility and current status of gene therapy for lower urinary tract dysfunction.

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“…In mice, CAR is mainly distributed in the heart, liver, brain, kidneys and lungs, with the highest expression level observed in the liver (5–7). Numerous studies have shown that CAR significantly functions as an important adhesion protein and molecule in viral infection (8–11) and the tumour development process (12–16).…”

Section: Introductionmentioning

confidence: 99%

Effects of heat stress on the expression of the coxsackievirus and adenovirus receptor in mouse skin keratinocytes

Deng

Jia

Chen

et al. 2013

Experimental and Therapeutic Medicine

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The aim of this study was to investigate the effects of heat stress on the expression of the coxsackievirus and adenovirus receptor (CAR) in mouse skin keratinocytes. Twenty BALB/c mice were randomly divided into two groups: the sham heat (control) and scald groups. Skin specimens were obtained 6 h after the treatments. Changes in the expression of CAR in skin keratinocyte samples were detected by immunohistochemistry, quantitative polymerase chain reaction and western blotting. In an in vitro assay, mouse skin keratinocytes were cultured and randomly divided into two groups: the normal control and heat stress groups. Six hours subsequently, the changes in CAR expression in the two groups were estimated by flow cytometry to determine the differences between the two groups. Heat stress significantly increased the expression of CAR in the mouse skin keratinocytes (P<0.05). The upregulation of CAR in mouse keratinocytes in burn wounds may be beneficial for restoring healing in organisms.

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Expression of Coxsackievirus and Adenovirus Receptor Isoforms in Developing Mouse Bladder Uroepithelium

Cited by 5 publications

References 26 publications

Sensitization of vitellogenin gene expression by low doses of octylphenol is mediated by estrogen receptor autoregulation in the Bombina orientalis (Boulenger) male liver

Sensitization of vitellogenin gene expression by low doses of octylphenol is mediated by estrogen receptor autoregulation in the Bombina orientalis (Boulenger) male liver

Gene therapy for lower urinary tract dysfunction

Effects of heat stress on the expression of the coxsackievirus and adenovirus receptor in mouse skin keratinocytes

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