Expression of COX-2 in Stomach Carcinogenesis

Forones, Nora Manoukian; Kawamura, Kharen Yaemi; Segreto, Helena Regina Cômodo; Neto, Ricardo Artigiani; Focchi, Gustavo Rubino de Azevedo; Oshima, Celina Tizuko Fujiyama

doi:10.1007/s12029-008-9039-6

Cited by 19 publications

(12 citation statements)

References 28 publications

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“…30,32,39,122 In addition to colorectal cancer, many other types of human malignancies have now been shown to overexpress COX-2, such as breast, pulmonary, head and neck, pancreatic, prostatic, and gastric cancers. 17,26,29,33,36,46,48,113 Several pieces of experimental evidence also support a role of COX-2 in the tumorigenic process of these cancers (see following sections). Although some studies revealing the expression of COX-1 in some cancers suggest that COX-1 could also contribute to oncogenesis in humans, notably in ovarian cancer, 22,34 this review does not address the possible role of COX-1 in animal cancers as there is currently little information on the subject.…”

Section: Cyclooxygenases and Cancermentioning

confidence: 91%

“…28,66,127 Similarly, the prognostic significance of COX-2 expression in other types of human cancers is controversial, with some studies supporting COX-2 as a useful predictive factor and other studies refuting such a role. 4,26,29,46,61,70,83,103,117,131 In animal cancers, there is currently not enough information to clearly define the prognostic significance of COX-2 expression. In most studies addressing COX-2 expression in animal cancers, a follow-up of the subjects is not available.…”

Section: Prognostic Significance Of Cox-2 Expressionmentioning

confidence: 99%

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Cyclooxygenase-2 Expression in Animal Cancers

Doré

2010

Vet Pathol

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Cyclooxygenase (COX; also known as prostaglandin endoperoxide synthase) is a key enzyme in the biochemical pathway leading to the synthesis of prostaglandins. A large amount of epidemiological and experimental evidence supports a role for COX-2, the inducible form of the enzyme, in human tumorigenesis, notably in colorectal cancer. COX-2 mediates this role through the production of PGE 2 that acts to inhibit apoptosis, promote cell proliferation, stimulate angiogenesis, and decrease immunity. Similarly, COX-2 is believed to be involved in the oncogenesis of some cancers in domestic animals. Here, the author reviews the current knowledge on COX-2 expression and role in cancers of dogs, cats, and horses. Data indicate that COX-2 upregulation is present in many animal cancers, but there is presently not enough information to clearly define the prognostic significance of COX-2 expression. To date, only few reports document an association between COX-2 expression and survival, notably in canine mammary cancers and osteosarcomas. Some evidence suggests that COX inhibitors could be useful in the prevention and/or treatment of certain cancers in domestic animals, the best example being urinary transitional cell carcinomas in dogs. However, determination of the levels of COX-2 in a tumor does not appear to be a good prognostic factor or a good indicator for the response to nonsteroidal anti-inflammatory drug therapy. Clearly, additional research, including the development of in vitro cell systems, is needed to determine if COX-2 expression can be used as a reliable prognostic factor and as a definite therapeutic target in animal cancers.

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Section: Cyclooxygenases and Cancermentioning

confidence: 91%

Section: Prognostic Significance Of Cox-2 Expressionmentioning

confidence: 99%

Cyclooxygenase-2 Expression in Animal Cancers

Doré

2010

Vet Pathol

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“…COX-2 expression is more prominent in intestinaltype gastric cancer when compared to the diffuse type (21,22). Ma et al (23) reported that COX-2 expression is essential for the survival and proliferation of gastric cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Assessment of COX-2 expression presence and severity by immunohistochemical method in patients with chronic active gastritis and intestinal metaplasia

Erkan

Gönül²,

Kandılcı³

et al. 2012

Turk J Gastroenterol

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“…High expression of COX-2 in a wide variety of solid epithelial tumors also favors the growth of malignant cells by inhibition of apoptosis and the promotion of angiogenesis [8]. Some studies have found a high correlation between the expression of this enzyme and cancer growth or prognosis [9,10].…”

Section: Original Studymentioning

confidence: 99%