Expression of COX-2, CD44v6 and CD147 and Relationship with Invasion and Lymph Node Metastasis in Hypopharyngeal Squamous Cell Carcinoma

Abstract

To assess the expression of COX-2,CD44v6 and CD147 in hypopharyngeal squamous cell carcinomas and the three biomarkers correlation with tumor invasion and lymph node metastasis of Chinese people. 101 cases of surgically excised primary tumor were included in this study, and 40 tissues of epithelium adjacent to carcinoma were used as controls. We characterized the immunohistochemical expression of COX-2, CD44v6, and CD147 in141 formalin-fixed, paraffin-embedded tissues, and measured the mean optical density (OD) of the positive area to identify the expression of the three bio-markers and relationship with tumor invasion and lymph node metastasis. Our study demonstrates that the expression of the COX-2 and CD147 were significantly increased in carcinoma tissues compared to the epithelium adjacent to carcinoma. We also observed that the expression of COX-2, CD44v6, and CD147 were significantly associated with T classification, lymph node metastasis and clinical stage. There was strong significant correlation among the three biomarkers as well. Additionally, we indicated that recurrence and ≥P50 level of COX-2 expression had an independent prognostic effect on prognosis. In conclusion, the three biomarkers play important roles in tumor invasion and lymph node metastases and might be valuable indicators of tumor metastasis in hypopharyngeal squamous cell carcinoma.

Study on extracellular matrix metalloproteinase inducer and human epidermal growth factor receptor-2 protein expression in papillary thyroid carcinoma using a quantum dot-based immunofluorescence technique

“…This shows that EMMPRIN protein expression is closely associated with LNM. The result corresponds well with the previously reported literature ( 24 , 25 ).…”

Clinicopathological and prognostic significance of cyclooxygenase-2 expression in head and neck cancer: A meta-analysis

“…9 studies were excluded as they did not provide sufficient data for extracting odds ratio (OR) or hazard ratio (HR) or 95% confidence intervals (CI) [28–36], leaving 29 studies that fulfilled the eligibility criteria [22–27, 37–59] (Table 1). Four studies reported no site-specific HNC [24, 54–57] and others recorded site-specific HNC. There were 7, 6 and 9 studies focused on oral cancer (OC) [22, 25, 27, 37–40], laryngeal cancer (LC) [41–46] and nasopharyngeal cancer (NPC) [23, 26, 47–53], respectively.…”

The altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters

“…Multivariate analysis has revealed that the expression of CD147 is an independent prognostic indicator for patients with HCC and non-small cell lung cancer [ 58 , 136 ]. In addition, low CD147 expression has also been suggested as a significantly favorable prognostic factor in gastric carcinoma [ 137 ], glioblastoma [ 138 ], endometrial cancer [ 139 ], and hypopharyngeal squamous cell carcinoma [ 140 ]. In patients with urothelial carcinoma of the bladder (UCB), univariate analysis revealed that high MCT1 and CD147 expressions were correlated with poor overall survival, whereas high MCT4 expression was associated with poor recurrence-free survival.…”