Expression of corticosteroid hormone receptors, prereceptors, and molecular chaperones in hypothalamic-pituitary-adrenal axis and adipose tissue after the administration of growth promoters in veal calves

Cucuzza, L. Starvaggi; Divari, Sara; Biolatti, B.; Cannizzo, Francesca Tiziana

doi:10.1016/j.domaniend.2020.106473

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…Fatty acids in adipose tissue are released by catecholamine and hormonal stimulation of a combination of enzymes, including acyl-triglyceride lipase, HSL, and MAGL ( Zechner et al, 2017 ). Recent studies show the expression of several neurotransmitters and hormone receptors on adipose tissue, suggesting an interaction of the brain and adipose tissue via the hypothalamic-pituitary-adipose axis or Brain-Fat-Axis ( Pedersen et al, 1996 ; Bluher, 2013 ; Kim et al, 2015 ; Cignarelli et al, 2019 ; Starvaggi Cucuzza et al, 2020 ; Im et al, 2021 ). When glucose levels are low or when energy demand is high, sympathetic pathways may stimulate the release of fatty acids through receptor signaling pathways involving PKA/PKG, PKC, tyrosine kinase, and ERK1/ERK2 ( Zechner et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Plasma Lipolysis and Changes in Plasma and Cerebrospinal Fluid Signaling Lipids Reveal Abnormal Lipid Metabolism in Chronic Migraine

Castor

Dawlaty

Arakaki

et al. 2021

Front. Mol. Neurosci.

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BackgroundLipids are a primary storage form of energy and the source of inflammatory and pain signaling molecules, yet knowledge of their importance in chronic migraine (CM) pathology is incomplete. We aim to determine if plasma and cerebrospinal fluid (CSF) lipid metabolism are associated with CM pathology.MethodsWe obtained plasma and CSF from healthy controls (CT, n = 10) or CM subjects (n = 15) diagnosed using the International Headache Society criteria. We measured unesterified fatty acid (UFA) and esterified fatty acids (EFAs) using gas chromatography-mass spectrometry. Glycerophospholipids (GP) and sphingolipid (SP) levels were determined using LC-MS/MS, and phospholipase A2 (PLA2) activity was determined using fluorescent substrates.ResultsUnesterified fatty acid levels were significantly higher in CM plasma but not in CSF. Unesterified levels of five saturated fatty acids (SAFAs), eight monounsaturated fatty acids (MUFAs), five ω-3 polyunsaturated fatty acids (PUFAs), and five ω-6 PUFAs are higher in CM plasma. Esterified levels of three SAFAs, eight MUFAs, five ω-3 PUFAs, and three ω-6 PUFAs, are higher in CM plasma. The ratios C20:4n-6/homo-γ-C20:3n-6 representative of delta-5-desaturases (D5D) and the elongase ratio are lower in esterified and unesterified CM plasma, respectively. In the CSF, the esterified D5D index is lower in CM. While PLA2 activity was similar, the plasma UFA to EFA ratio is higher in CM. Of all plasma GP/SPs detected, only ceramide levels are lower (p = 0.0003) in CM (0.26 ± 0.07%) compared to CT (0.48 ± 0.06%). The GP/SP proportion of platelet-activating factor (PAF) is significantly lower in CM CSF.ConclusionsPlasma and CSF lipid changes are consistent with abnormal lipid metabolism in CM. Since plasma UFAs correspond to diet or adipose tissue levels, higher plasma fatty acids and UFA/EFA ratios suggest enhanced adipose lipolysis in CM. Differences in plasma and CSF desaturases and elongases suggest altered lipid metabolism in CM. A lower plasma ceramide level suggests reduced de novo synthesis or reduced sphingomyelin hydrolysis. Changes in CSF PAF suggest differences in brain lipid signaling pathways in CM. Together, this pilot study shows lipid metabolic abnormality in CM corresponding to altered energy homeostasis. We propose that controlling plasma lipolysis, desaturases, elongases, and lipid signaling pathways may relieve CM symptoms.

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Section: Discussionmentioning

confidence: 99%

Plasma Lipolysis and Changes in Plasma and Cerebrospinal Fluid Signaling Lipids Reveal Abnormal Lipid Metabolism in Chronic Migraine

Castor

Dawlaty

Arakaki

et al. 2021

Front. Mol. Neurosci.

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“…First, the heat challenge was not sufficient to cause changes in the expression of the gene. The second limitation is that only blood samples were used, while other studies analyzed pituitary glands (Li et al, 2017), liver (Depke et al, 2009), and hypothalamus (Cucuzza et al, 2020). Furthermore, the possible adaptation of the Caracu and Nelore breeds to HS conditions may have influenced NR3C1 expression.…”

Section: Tablementioning

confidence: 99%

Análise de parâmetros fisiológicos e perfil de expressão de genes associados ao estresse térmico e eficiência alimentar em bovinos das raças Nelore e Caracu

Pires¹

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Análise de parâmetros fisiológicos e perfil de expressão de genes associados ao estresse térmico e eficiência alimentar em bovinos das raças Nelore e Caracu Ribeirão Preto 2021 BIANCA VILELA PIRES Análise de parâmetros fisiológicos e perfil de expressão de genes associados ao estresse térmico e eficiência alimentar em bovinos das raças Nelore e Caracu "Versão corrigida. A versão original encontra-se disponível tanto na Biblioteca da Unidade que aloja o Programa, quanto na Biblioteca Digital de Teses e Dissertações da USP (BDTD)"

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FKBP5 gene expression in skeletal muscle as a potential biomarker for illegal glucocorticoid treatment in veal calves

Cucuzza

Pregel

Biolatti

et al. 2020

Research in Veterinary Science

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Expression of corticosteroid hormone receptors, prereceptors, and molecular chaperones in hypothalamic-pituitary-adrenal axis and adipose tissue after the administration of growth promoters in veal calves

Cited by 3 publications

References 37 publications

Plasma Lipolysis and Changes in Plasma and Cerebrospinal Fluid Signaling Lipids Reveal Abnormal Lipid Metabolism in Chronic Migraine

Plasma Lipolysis and Changes in Plasma and Cerebrospinal Fluid Signaling Lipids Reveal Abnormal Lipid Metabolism in Chronic Migraine

Análise de parâmetros fisiológicos e perfil de expressão de genes associados ao estresse térmico e eficiência alimentar em bovinos das raças Nelore e Caracu

FKBP5 gene expression in skeletal muscle as a potential biomarker for illegal glucocorticoid treatment in veal calves

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