Expression of connexin 30 in the developing mouse cochlea

Xia, Anping; Katori, Yukio; Oshima, Takeshi; Watanabe, Kenji; Kikuchi, Toshihiko; Ikeda, Katsuhisa

doi:10.1016/s0006-8993(01)02216-8

Cited by 37 publications

(31 citation statements)

References 17 publications

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“…The Cx30 blocking peptide was kindly provided by Zymed. These antibodies have been previously characterized (20 -22, 24, 32), and the Cx30 antibody used in the present studies has been demonstrated to recognize Cx30 in the brain and cochlea using both immunoblot and immunohistochemistry of mouse and rat tissue (22,24,32). The mouse monoclonal anti-pendrin antibody was purchased from MBL International (Woburn, MA).…”

Section: Methodsmentioning

confidence: 99%

Localization of connexin 30 in the luminal membrane of cells in the distal nephron

McCulloch

Chambrey²,

Eladari³

et al. 2005

American Journal of Physiology-Renal Physiology

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Section: Methodsmentioning

confidence: 99%

Localization of connexin 30 in the luminal membrane of cells in the distal nephron

McCulloch

Chambrey²,

Eladari³

et al. 2005

American Journal of Physiology-Renal Physiology

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“…Immunostaining demonstrated that connexin26 (Cx26) is expressed by both systems (Kikuchi et al 1995). The distribution and expression of Cx30 were found to be nearly the same as that of Cx26 (Xia et al 2001). The dense immunoreactivity of Cx31 was observed in the fibrocytes of the spiral ligament and the spiral limbus, but not in the epithelial gap junctional system (Xia et al 2000).…”

Section: Gap Junction Proteinsmentioning

confidence: 95%

Gene-Based Deafness Research: Ion Transport and Hearing

Ikeda

2004

Tohoku J. Exp. Med.

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The cochlea is a sensory organ that converts physical (sound) stimulation into electrical signals. This process is fundamentally and substantially based upon the ion transport system. Here, I summarize the physiological and molecular biological aspects of transporters, channels and receptors expressed in the cochlea. With reference to these findings, recent advances in genetic research on hereditary deafness are discussed.deafness; ion transport; hereditary deafness; DNA

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“…Cx30 and Cx43 have been detected in the rat cochlea as well as Cx26 [48, 49]; Cx26 and Cx30 have also been identified in the inner ear of human and rat embryos [50, 51]. Cx31 has been found to be expressed in the developing mouse cochlea [52].…”

Section: Can Other Gene Variations Modulate the Effects Of Gjb2 Mutatmentioning

confidence: 99%

Progress in Understanding GJB2-Linked Deafness

Gualandi¹,

Calzolari²

2003

Public Health Genomics

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Mutations in the GJB2 gene (encoding for Connexin 26 protein) represent a leading cause of genetic hearing impairment. Extensive epidemiological and molecular studies have been reported, describing GJB2 mutations type, frequency and distribution. Moreover, several aspects of GJB2 mutations pathogenic effects have been elucidated taking advantage of in vitro and in vivo experimental approaches. Progress through reported studies is reviewed, highlighting recent major achievements in this field. Attention is focused on different unresolved questions regarding GJB2 deafness pathogenesis and genotype-phenotype relationships. Clarification of these important clues will significantly increase our understanding of the molecular basis of hearing loss and will improve the effectiveness of diagnosis and counselling of this frequent disease.

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Expression of connexin 30 in the developing mouse cochlea

Cited by 37 publications

References 17 publications

Localization of connexin 30 in the luminal membrane of cells in the distal nephron

Localization of connexin 30 in the luminal membrane of cells in the distal nephron

Gene-Based Deafness Research: Ion Transport and Hearing

Progress in Understanding GJB2-Linked Deafness

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