Expression of Concern on “miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14”

International, BioMed Research

doi:10.1155/2019/8739375

Cited by 3 publications

(3 citation statements)

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“…MiR-195-5p was reported to function as a suppressor in tumor development. In oral squamous cell carcinoma, miR-195-5p can suppress cell proliferation, migration and invasion via targeting TRIM14 [39]. In ovarian cancer, overexpression of miR-195-5p can reduce cisplatin resistance and angiogenesis via PSAT1-depedent GSK3β/β-catenin signaling pathway [40].…”

Section: Discussionmentioning

confidence: 99%

MiR-195-5p is a Potential Factor Responsible for CPNE1 Differential Expression between Subtypes of Non-Small Cell Lung Cancer

Liu

Zhang

et al. 2020

J. Cancer

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Purpose: Lung cancer is the most common malignancy with poor 5-year survival among men and women. Previous studies have shown that CPNE1 is up-regulated in non-small cell lung cancer (NSCLC). However, whether and how CPNE1 expression varies between different subtypes of NSCLC remains less understood. Methods: Bioinformatical analysis and GSE19188 were selected to confirm CPNE1 expression in different subtypes of NSCLC. Four microRNA prediction websites and GSE53883, GSE43000 were used to evaluate the possible targeting microRNAs. Kaplan-Meier survival curves were drawn based on Tumor Lung Bild-114 dataset using R2, UCSC Xena browser or linkedomics platform. Furthermore, we verified our prediction via qRT-PCR, and western blot and luciferase reporter assays. Results: we demonstrated that higher CPNE1 expression was associated with poorer survival in NSCLC patients. Moreover, among the different subtypes, patients with squamous cell lung cancer (SCC) exhibited higher level of CPNE1 expression, as well as substantially poorer survival. MiR-195-5p was down-regulated in NSCLC tissues. Interestingly, SCC patients showed lower miR-195-5p expression compared to patients with lung adenocarcinoma (ADC). In addition, functional assays proved that miR-195-5p overexpression inhibited the proliferation, migration, and invasion of NSCLC-derived cells by directly targeting CPNE1. Pathway analysis showed decreased expression of p-AKT, pErk , and Snail after transfection with miR-195-5p mimics in both lung adenocarcinoma and squamous cell lines. Conclusion: Our findings suggested that miR-195-5p regulation contributed to the differential expression of CPNE1 in NSCLC subtypes.

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Section: Discussionmentioning

confidence: 99%

MiR-195-5p is a Potential Factor Responsible for CPNE1 Differential Expression between Subtypes of Non-Small Cell Lung Cancer

Liu

Zhang

et al. 2020

J. Cancer

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“…Epithelial to mesenchymal transition (EMT) as well as many other processes such as cell migration and proliferation are influenced by miRNAs [6]. Several studies on the molecular mechanisms involved in different kinds of cancers have revealed that the expression of miR-195-5p is dysregulated [7]. During oncogenesis, a process in which normal cells transform into carcinoma cells in situ, EMT plays a crucial role [8].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of gastric cancer cell growth, invasion and metastasis by tocotrienolic amide

Huang¹,

Xu²

2021

Trop. J. Pharm Res

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Purpose: To investigate the effect of tocotrienolic amide on gastric cancer (GC) cell growth and metastasis, and the underlying mechanism of action.Methods: Gastric cancer (GC) cell lines MKN28 and NCI-N87 were cultured in Dulbecco's modified Eagle medium (DMEM) supplemented with 10 % fetal bovine serum (FBS) and 1 % penicillin/streptomycin solution at 37 ˚C in a humidified atmosphere of 5 % CO2 and 95 % air. Cell invasion and migration were determined using Transwell and wound healing assays, respectively. Realtime quantitative polymerase chain reaction (qRT-PCR) and Western blotting were used for the determination of changes in the levels of expression of Snail, E-cadherin, vimentin, and microRNA-195-5p (miR-195-5p). In vivo tumor growth inhibition was determined 45 days after establishment of GC xenografts in nude mice.Results: Treatment of MKN28 and NCI-N87 cells with tocotrienolic amide significantly and dosedependently reduced their invasiveness and migratory capacity (p < 0.05). It also significantly and dosedependently downregulated the mRNA and protein expressions of Snail and vimentin, but significantly upregulated E-cadherin expression (p < 0.05). The mRNA expression of miR-195-5p was significantly and dose-dependently upregulated in MKN28 and NCI-N87 cells treated with tocotrienolic amide, but was downregulated after transfection with miR-195-5p inhibitor (p < 0.05). Transfection of MKN28 and NCI-N87 cells with miR-195-5p inhibitor significantly and dose-dependently upregulated mRNA and protein expressions of Snail (p < 0.05). Moreover, treatment of GC mice with TCTA led to significant and dose-dependent reduction in tumor weight and volume (p < 0.05).Conclusion: These results suggest that tocotrienolic amide inhibits the growth and metastasis of GC cells by directly targeting Snail and vimentin genes, and thus can potentially be developed for the management of gastric cancer. Keywords: Gastric cancer, Metastasis, Protein expression, Tocotrienolic amide, Tumor volume

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“…In the article titled “miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14” [ 1 ], a figure duplication was identified in Figure 4(f) as noted in an earlier Expression of Concern [ 2 ]. With the agreement of the editorial board, the authors have repeated the migration and invasion experiments and provided a revised Figure 4 as below:…”

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confidence: 99%

Corrigendum to “miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14”

Wang

Ren

Liu

et al. 2022

BioMed Research International

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Expression of Concern on “miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14”

Cited by 3 publications

References 1 publication

MiR-195-5p is a Potential Factor Responsible for CPNE1 Differential Expression between Subtypes of Non-Small Cell Lung Cancer

MiR-195-5p is a Potential Factor Responsible for CPNE1 Differential Expression between Subtypes of Non-Small Cell Lung Cancer

Inhibition of gastric cancer cell growth, invasion and metastasis by tocotrienolic amide

Corrigendum to “miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14”

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