Expression of collagenase-3 (matrix metalloproteinase-13) in human gastric cancer

Abstract

tive form of MMP-13 or one of its intermediate forms. Also, zymographic analysis of the tumor specimens revealed strong gelatinolytic bands of MMP-13 and MMP-2, whereas these bands in normal mucosa were weak. There was no significant relationship between MMP-13 mRNA expression and histologic type, lymph node metastasis, wall invasion, or distant metastasis. However, patients with MMP-13 mRNA-positive tumors had a poorer prognosis than those with MMP-13-mRNA-negative cancer. Furthermore, patients with simultaneous expression of MMP-13 and MT1-MMP mRNA showed the poorest prognosis, as compared with those having tumors expressing either MMP-13 or MT1-MMP, or neither MMP-13 nor MT1-MMP mRNA. Conclusion. These findings suggest that MMP-13 expression may contribute to the progression of gastric cancer, and its coordinate overexpression with MT1-MMP and/or MMP-2 may have a cooperative effect in the progression of gastric cancer.

Quantitative Real-Time RT-PCR of ITGA7, SVEP1, TNS1, LPHN3, SEMA3G, KLB and MMP13 mRNA Expression in Breast Cancer

“…MMP13 or collagenase-3 is a member of the matrix metalloproteinase family of endopeptidases that have potent degrading activity for degrading the major protein components of the extracellular matrix and basement membranes of the cells (Pendás et al, 2000). MMP13 is induced during invasion and metastasis of head and neck cancer, skin cancer, gastric cancer and breast cancer (Nielsen et al, 2001;Elnemr et al,2003;Luukkaa et al, 2006;Lederle et al, 2010). This study demonstrated that mRNA expression of LPHN3 and MMP13 is directly linked to tumor aggressiveness, since the common first route of spread for breast carcinoma is through the axillary lymph nodes.…”

“…These genes play a role in cell adhesion and migration (Elnemr et al, 2003;Shur et al, 2007;Karayan-Tapon et al, 2008;Hall et al, 2009;Zhu et al, 2010;Martinez et al, 2011;. Moreover, the association between mRNA expression and the clinical characteristics of these patients was evaluated.…”

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

“…MMP-13 was originally found in breast carcinoma, but it is now associated with other types of human cancer, such as chondrosarcomas (Uria et al, 1998), gastric cancer (Elnemr et al, 2003), basal cell carcinomas (Hattori et al, 2003), and squamous cell carcinomas of the head and neck, larynx, vulva, and epithelium of the skin (Airola et al, 1997;Cazorla et al, 1998;Johansson et al, 1997bJohansson et al, , 1999). An extensive overview of MMP-13 expression in malignant tumors has been recently published .…”

Matrix metalloproteinases and gastrointestinal cancers: Impacts of dietary antioxidants

“…In addition to MMPs, TIMP-1 and TIMP-2 were detected in approximately 50% of gastric tumors. Progression of gastric cancer is associated with MMP-13 expression along with its coexpression with MT1-MMP and/or MMP-2 that may have a synergistic effect in the progression of the disease [36] . The expression of TIMP-3 was significantly higher than that of MMP-3, and MMP-3/TIMP-3 was lower in gastric cancer tissue at the early stages (n = 18) than in that of the advanced stage group (n = 26) (P < 0.05) [37] .…”