Expression of Collagen IV .ALPHA.1 to .ALPHA.6 Chains in Basement Membranes of Odontogenic Tumors

Abstract

Type IV collagen, the major component of basement membrane (BM), demonstrates a stage-and position-specific distribution of its isoforms during tooth development. To determine its localization in BM of odontogenic neoplasms, immunohistochemistry using six anti-(IV) chain-specific monoclonal antibodies was performed. Expression of 1(IV)/ 2(IV) and 5(IV)/ 6(IV) chains was stronger in the desmoplastic than in ordinary ameloblastomas. The adenomatoid odontogenic tumor distinctly expressed these chains in BM of cribriform areas and hyaline materials (which was also 4(IV)-positive. These five chains also stained BM and tumor cells of ameloblastic fibroma. Present results suggest that collagen IV composition and distribution in the basement membranes of odontogenic neoplasms plays a key role in tumor growth and progression.

Differential Distribution of Type IV Collagen .ALPHA.1 to .ALPHA.6 Chains Suggests Distinct Molecular Interaction between the Epithelial and Mesenchymal Components of Benign Odontogenic Tumors

“…Differential expression of α(IV) chains in BMs of benign and malignant odontogenic tumors have been studied and the authors suggested that modification and remodeling of these molecules occur during odontogenic tumor progression 28,29) .…”

“…chains isoform were performed in mouse tooth germ and in odontogenic tumors independently 27,28,29) . In current study, we exam- (Fig.5, f-k).…”

Co-expression of BMP-2 and -7 in the Tumoral Epithelium of CEOT with Selective BMP-7 Expression in Amyloid Materials

“…Odontogenic tumors constitute a clinically significant group of jawbone neoplasms in the Asian region and are therefore a subject of considerable research [14][15][16][17][18][19][20][21][22][23][24][25] . Among the most well-studied are ameloblastomas [14][15][16][17][18][19] , adenomatoid odontogenic tumor 15,20) , keratocystic odontogenic tumor [21][22][23] and calcifying cystic odontogenic tumor [24][25] . These works have enumerated the clinicopathologic characteristics and clarified the various signaling molecules implicated in the development of the various tumor entities [15][16][17][18][19][20][21][22][23][24][25] .…”

“…Among the most well-studied are ameloblastomas [14][15][16][17][18][19] , adenomatoid odontogenic tumor 15,20) , keratocystic odontogenic tumor [21][22][23] and calcifying cystic odontogenic tumor [24][25] . These works have enumerated the clinicopathologic characteristics and clarified the various signaling molecules implicated in the development of the various tumor entities [15][16][17][18][19][20][21][22][23][24][25] . Limited work has been published on Notch signaling proteins in the squamous odontogenic tumor 26) .…”