Expression of Co-stimulatory Molecules on Langerhans Cells in Lesional Epidermis of Human Atopic Dermatitis

Fesenkova, Valentyna I.; Kurchenko, A.I.; Castellani, M.L.; Conti, Pio; Anogeianaki, A.; Caraffa, Auro; Kalogeromitros, D.

doi:10.1080/08923970701675101

Cited by 5 publications

(2 citation statements)

References 52 publications

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“…The NAB2 , which also interacts with the transmembrane protein KIAA0286 in our asthma model, has been shown to modulate the vascular endothelial growth factor ( VEGF ) pathway. We and others have previously shown that the VEGF pathway is implicated in asthma pathogenesis and airway remodeling that occurs in persistent asthmatics (28). These gene relationships, which could not be identified by our single‐SNP analysis, are interesting biologic candidates for follow‐up investigation.…”

Section: Discussionmentioning

confidence: 99%

Association of variants in innate immune genes with asthma and eczema

Sharma

Poon

Himes

et al. 2011

Pediatric Allergy Immunology

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Background The innate immune pathway is important in the pathogenesis of asthma and eczema. However, only a few variants in these genes have been associated with either disease. We investigate the association between polymorphisms of genes in the innate immune pathway with childhood asthma and eczema. In addition, we compare individual associations with those discovered using a multivariate approach. Methods Using a novel method, case control based association testing (C2BAT), 569 single nucleotide polymorphisms (SNPs) in 44 innate immune genes were tested for association with asthma and eczema in children from the Boston Home Allergens and Asthma Study and the Connecticut Childhood Asthma Study. The screening algorithm was used to identify the top SNPs associated with asthma and eczema. We next investigated the interaction of innate immune variants with asthma and eczema risk using Bayesian networks. Results After correction for multiple comparisons, 7 SNPs in 6 genes (CARD25, TGFB1, LY96, ACAA1, DEFB1, and IFNG) were associated with asthma (adjusted p-value<0.02), while 5 SNPs in 3 different genes (CD80, STAT4, and IRAKI) were significantly associated with eczema (adjusted p-value < 0.02). None of these SNPs were associated with both asthma and eczema. Bayesian network analysis identified 4 SNPs that were predictive of asthma and 10 SNPs that predicted eczema. Of the genes identified using Bayesian networks, only CD80 was associated with eczema in the single-SNP study. Using novel methodology that allows for screening and replication in the same population, we have identified associations of innate immune genes with asthma and eczema. Bayesian network analysis suggests that additional SNPs influence disease susceptibility via SNP interactions. Conclusion Our findings suggest that innate immune genes contribute to the pathogenesis of asthma and eczema, and that these diseases likely have different genetic determinants.

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Section: Discussionmentioning

confidence: 99%

Association of variants in innate immune genes with asthma and eczema

Sharma

Poon

Himes

et al. 2011

Pediatric Allergy Immunology

View full text Add to dashboard Cite

show abstract

“…They bind with corresponding receptor or ligand on T cells surface, which serves as the second signal for T cell activation. Recent study reported that the CD80/CD86 mediated signal determines the polarization of the T cell differentiation towards either Th1 or Th2 [24]. In our in vitro experiments, we showed that VIP significantly up-regulated the expression of CD80, CD86, CD40, CD54 in a dose dependent manner.…”

Section: Discussionmentioning

confidence: 54%