Expression of Claudin-4 in Lung Ischemia-Reperfusion Injury in Experimental Lung Transplantation

Is Claudin 4 a Player to Be Reckoned with or Not in the Context of Lung Transplantation?

“…Claudin 4 (CLDN4), is expressed by Type I and Type II epithelial alveolar cells, which covers more or less the entire alveolar epithelium and is a component of tight junction strands and has been shown to have impact in acute lung injury and may also play a role in PGD [8]. Using a pig lung transplantation model Luna-Flores and colleagues have investigated if CLDN4 may be used as a biomarker for PGD [9]. In the present study, all pigs developed primary graft dysfunction with increased pulmonary edema verified both in wet/dry ratio and x-ray in combination with hypoxia.…”