Expression of Class II-MHC Antigens on Alveolar and Bronchiolar Epithelial Cells in Fibrosing Alveolitis

Beaumont, F; Schilizzi, B. M.; Kallenberg, Cees G. M.; Ley, Loe de

doi:10.1378/chest.89.3_supplement.136s

Cited by 8 publications

(1 citation statement)

References 8 publications

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“…Despite the lack of classic GVHD histopathology, it is not unreasonable to suggest that pulmonary epithelial and endothelial cells can be potential targets for activated donor T cells after allo SCT. First, the lung is a rich source of major and minor histocompatibility (HC) antigens and professional antigen-presenting cells (62,63) and is the site of complex immunologic networks, the proper balance of which allows for infectious surveillance and maintenance of structural integrity, whereas dysregulation of such networks can result in tissue injury and scarring (64). Furthermore, the inflammatory mediators TNF-a andLPS, which are believed to playa part in GVHD (52,54,65), have also been implicated as contributors to pulmonary dysfunction in several experimental systems and clinical syndromes, including adult respiratory distress syndrome (ARDS), lung allograft rejection, and pneumonitis after toxin exposure (32-36,39,66--69).…”

Section: Pathogenesis Of Idiopathic Pneumonia Syndrome: the Lung As A...mentioning

confidence: 99%

Pathophysiology of Lung Injury After Hematopoietic Stem Cell Transplantation

Cooke¹

2004

Stem Cell Transplantation for Hematologic Malignancies

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Section: Pathogenesis Of Idiopathic Pneumonia Syndrome: the Lung As A...mentioning

confidence: 99%

Pathophysiology of Lung Injury After Hematopoietic Stem Cell Transplantation

Cooke¹

2004

Stem Cell Transplantation for Hematologic Malignancies

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Lung Injury after Hematopoietic Stem Cell Transplantation

Cooke

Yanik

2008

Hematopoietic Stem Cell Transplantation

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Phenotypic characterization of alveolar capillary endothelial cells, alveolar epithelial cells and alveolar macrophages in patients with pulmonary fibrosis, with special reference to MHC class II antigens

Komatsu

Yamamoto

Shimokata

et al. 1989

Vichows Archiv A Pathol Anat

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Major histocompatibility complex (MHC) class II antigens are essential in the presentation of antigens to T lymphocytes, and cells expressing MHC class II antigens are known to play a role as antigen presenting cells (APC). We investigated the distribution of MHC class II antigens and the reactivity of monoclonal antibodies OKM1 and OKM5 in normal and fibrotic lungs immunohistochemically. The results showed that alveolar capillary endothelial cells (ACEnd) expressed MHC class II antigens and were reactive with OKM5 in both normal lungs and the non-thickened parts of alveolar septa of pulmonary fibrosis. However, ACEnd did not express MHC class II antigens and were not reactive with OKM5 in thickened alveolar septa of pulmonary fibrosis. Type II alveolar epithelial cells (AEp) proliferating and replacing type I AEp in pulmonary fibrosis expressed MHC class II antigens strongly. Alveolar macrophages expressed MHC class II antigens strongly and reacted with OKM1 in pulmonary fibrosis, especially in alveolar spaces. These findings suggest that the phenotypic changes of ACEnd may be involved in the process of pulmonary fibrosis, and type II AEp and alveolar macrophages in the parts of thickened alveolar septa may play a role as APC.

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Expression of Class II-MHC Antigens on Alveolar and Bronchiolar Epithelial Cells in Fibrosing Alveolitis

Cited by 8 publications

References 8 publications

Pathophysiology of Lung Injury After Hematopoietic Stem Cell Transplantation

Pathophysiology of Lung Injury After Hematopoietic Stem Cell Transplantation

Lung Injury after Hematopoietic Stem Cell Transplantation

Phenotypic characterization of alveolar capillary endothelial cells, alveolar epithelial cells and alveolar macrophages in patients with pulmonary fibrosis, with special reference to MHC class II antigens

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