Expression of circulating microRNAs as predictors of diagnosis and surgical outcome in patients with mesial temporal lobe epilepsy with hippocampal sclerosis

Ioriatti, Enrico Salomão; Cirino, Mucio Luiz Assis; Neto, Fermino Sanches Lizarte; Velasco, Tonicarlo Rodrigues; Sakamoto, Américo Ceiki; Freitas‐Lima, Priscila; Tirapelli, Daniela Pretti da Cunha; Carlotti, Carlos Gilberto

doi:10.1016/j.eplepsyres.2020.106373

Cited by 21 publications

(26 citation statements)

References 33 publications

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“…In mesial TLE with hippocampal sclerosis, a study involving serum samples from 28 patients and 11 healthy volunteers, compared individuals with good surgical prognosis and poor surgical prognosis according to the Engel surgical outcome scale. RT-PCR analysis identified miR-654-3p as a potential predictor of good surgical outcomes [56]. If similar observations are found to be associated with other types of epilepsy, miRNA profiling could become a novel gold standard predictor of drug responsiveness or surgical outcomes for epilepsy procedures.…”

Section: Mirnas and Epilepsymentioning

confidence: 86%

Liquid Biopsies in Epilepsy: Biomarkers for Etiology, Diagnosis, Prognosis, and Therapeutics

Whitlock¹,

Soelter²,

Williams³

et al. 2021

Preprint

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Epilepsy is one of the most common disorders of the central nervous system, impacting nearly 50 million people around the world. Heterogeneous in nature, epilepsy presents in children and adults alike. Currently, surgery is the only treatment that can cure epilepsy. However, not all individuals are eligible or have successful outcomes. Difficulty in accessing samples of human brain tissue along with advances in sequencing technology have driven researchers to investigate sampling liquid biopsies in blood, serum, plasma, and cerebrospinal fluid within the context of epilepsy. Liquid biopsies provide minimal or non-invasive sample collection approaches and can be assayed relatively easily across multiple time points, unlike tissue-based sampling. Various efforts have investigated circulating nucleic acids from these samples including microRNAs, cell-free DNA, transfer RNAs, and long non-coding RNAs. Here, we review nucleic acid-based liquid biopsies in epilepsy to improve understanding of etiology, diagnosis, prediction, and therapeutic monitoring.

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Section: Mirnas and Epilepsymentioning

confidence: 86%

Liquid Biopsies in Epilepsy: Biomarkers for Etiology, Diagnosis, Prognosis, and Therapeutics

Whitlock¹,

Soelter²,

Williams³

et al. 2021

Preprint

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show abstract

“…However, miR-328-3p could differentiate controls from Engel I, controls from Engel III-IV and controls from Engel I + Engel III-IV patients with diagnostic power values of 90.3%, 96.8% and 93.5%, respectively. In addition, miR-654-3p could differentiate controls from Engel I patients as well as patients with unfavorable from favorable surgical outcome with lower values [58].…”

Section: Diagnostic/prognostic Role Of Mirnas In Epilepsymentioning

confidence: 97%

Aberrant expression of miRNAs in epilepsy

et al. 2022

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Epilepsy is manifested by intermittent convulsions and alterations in consciousness. This disorder has serious effects on daily functions and physical and mental health of affected patients. A variety of temporary irregularities in the function of brain can results in epilepsy. The molecular mechanism of epilepsy and the underlying causes of abnormal apoptotic responses in neurons, dysregulation of regenerative mechanisms in glial cells and abnormal immune reactions in the context of epilepsy are not clear. microRNAs (miRNAs) as important regulators of cell apoptosis as well as regenerative and immune responses have been shown to affect pathologic events in epilepsy. In the current review, we aimed at defining the role of miRNAs in the pathophysiology of epilepsy. We have listed dysregulated miRNAs in animal models of epilepsy and human subjects. miR-25-3p, miR-494, miR-139-5p, miR-101a-3p, miR-344a, miR-129, miR-298 and miR-187 are among down-regulated miRNAs in epilepsy. Moreover, expressions of miR-132, miR-146a, miR-181a and miR-155 have been reported to be increased in epilepsy. A number of genetic variants within miRNAs can affect risk of epilepsy. We discuss the role of miRNAs in the development of epilepsy.

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“…Serum miR-328-3p is also an important peripheral biomarker for the diagnosis of MTLE-HS with high area under the curve (AUC) values when comparing controls to Engel I (90.3%). For predicting the surgical prognosis of MTLE-HS patients, miR-654-3p had statistical power as a peripheral biomarker (AUC = 73.6%) to differentiate Engel I from Engel III-IV patients (Ioriatti et al, 2020). Wang et al (2015b) used Illumina HiSeq2000 sequencing to screen for differentially expressed miRNAs in the serum of 30 epilepsy patients and 30 healthy controls.…”

Section: Mirnas As Biomarkers Of Epilepsymentioning

confidence: 99%

MicroRNA Dysregulation in Epilepsy: From Pathogenetic Involvement to Diagnostic Biomarker and Therapeutic Agent Development

Wang

Zhao

2021

Front. Mol. Neurosci.

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Epilepsy is the result of a group of transient abnormalities in brain function caused by an abnormal, highly synchronized discharge of brain neurons. MicroRNA (miRNA) is a class of endogenous non-coding single-stranded RNA molecules that participate in a series of important biological processes. Recent studies demonstrated that miRNAs are involved in a variety of central nervous system diseases, including epilepsy. Although the exact mechanism underlying the role of miRNAs in epilepsy pathogenesis is still unclear, these miRNAs may be involved in the inflammatory response in the nervous system, neuronal necrosis and apoptosis, dendritic growth, synaptic remodeling, glial cell proliferation, epileptic circuit formation, impairment of neurotransmitter and receptor function, and other processes. Here, we discuss miRNA metabolism and the roles of miRNA in epilepsy pathogenesis and evaluate miRNA as a potential new biomarker for the diagnosis of epilepsy, which enhances our understanding of disease processes.

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Expression of circulating microRNAs as predictors of diagnosis and surgical outcome in patients with mesial temporal lobe epilepsy with hippocampal sclerosis

Cited by 21 publications

References 33 publications

Liquid Biopsies in Epilepsy: Biomarkers for Etiology, Diagnosis, Prognosis, and Therapeutics

Liquid Biopsies in Epilepsy: Biomarkers for Etiology, Diagnosis, Prognosis, and Therapeutics

Aberrant expression of miRNAs in epilepsy

MicroRNA Dysregulation in Epilepsy: From Pathogenetic Involvement to Diagnostic Biomarker and Therapeutic Agent Development

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