Expression of Chr9p21 genes CDKN2B (p15INK4b), CDKN2A (p16INK4a, p14ARF) and MTAP in human atherosclerotic plaque

The Severity of Internal Carotid Artery Stenosis is Associated with the Cyclin-Dependent Kinase Inhibitor 2A Gene Expression

“…INK4a is not affected by the expression of ANRIL NR_003529 transcripts, consistent with the results obtained by Holdt et al 33) Additionally, many SNPs in the 9p21 region may interact with each other, thereby regulating the expression patterns of neighboring genes and influencing the gene expression.…”

“…The authors also stated that the expression levels of ANRIL EU741058 and NR_003529 were not correlated with that of CDKN2A mRNA 33) . In the present study, we found that the level of ANRIL NR_003529 transcripts was inversely correlated with the CDKN2A expression; however, our results were also not statistically significant.…”

“…INK4b and p16 INK4a in human coronary and thoracic atherosclerotic arteries and showed that these proteins are co-localized with macrophages and SMCs 33) . In the present study, we demonstrated however, the results are conflicting.…”

“…To our knowledge, there are two published reports examining the vascular protein expression of genes adjacent to the chromosome 9p21 core region 27,33) .…”

“…Recent studies have shown correlations between 9p21 SNPs and transcription at this locus 28,33,36,37) ; in patients exhibiting severe ICA stenosis. These findings indicate that CDKN2A transcripts may affect the pathogenesis of CA and that the p16 INK4a protein expression levels differ according to the CA subgroup.…”