Expression of Cholecystokinin Type A Receptor Gene Correlates with DNA Demethylation during Postnatal Development of Rat Pancreas

Matsusue, Kimihiko; Takiguchi, Soichi; Takata, Yutaka; Funakoshi, Akihiro; Miyasaka, Kyoko; Kono, Akira

doi:10.1006/bbrc.1999.1459

Cited by 14 publications

(8 citation statements)

References 16 publications

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“…Actually, the polymorphic Ϫ128 G is also in the CpG dinucleotide sequence. If an effect of methylation, as shown for rat CCKAR expression, 19 is also found for human CCKAR expression, this polymorphism may have some effect on transcription of this gene. This must be examined in further studies.…”

Section: Discussionmentioning

confidence: 85%

Promoter analysis of human cholecystokinin type-A receptor gene

Takata

Takeda

Kawanami

et al. 2002

Journal of Gastroenterology

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Section: Discussionmentioning

confidence: 85%

Promoter analysis of human cholecystokinin type-A receptor gene

Takata

Takeda

Kawanami

et al. 2002

Journal of Gastroenterology

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“…CCK-AR is rich in the pancreas of rats, mice, and guinea pigs [4,19], and pancreatic protein secretion is fully responsible for CCK in these animals. However, a disruption of the CCK-AR gene showed no serious changes in the pancreas except for no response to CCK [8].…”

Section: Discussionmentioning

confidence: 99%

Importance of CCK-A Receptor for Gallbladder Contraction and Pancreatic Secretion: A Study in CCK-A Receptor Knockout Mice.

Suzuki

Takiguchi²,

Sato³

et al. 2001

JJP

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“…The gene expression and/or protein distribution of CCK1 and CCK2 have been reported (Wank 1995, Bourassa et al 1999. CCK1 is enriched in the pancreas and specific brain regions, whereas CCK2 is widely distributed throughout the CNS (Honda et al 1993, Wank 1995, Matsusue et al 1999. However, the expression of CCK receptors in mature sperm has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Cholecystokinin receptors regulate sperm protein tyrosine phosphorylation via uptake of HCO3−

Zhou

Shi

et al. 2015

Reproduction

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Cholecystokinin (CCK), a peptide hormone and a neurotransmitter, was detected in mature sperm two decades ago. However, the exact role of CCK and the types of CCK receptors (now termed CCK1 and CCK2) in sperm have not been identified. Here, we find that CCK1 and CCK2 receptors are immunolocalized to the acrosomal region of mature sperm. The antagonist of CCK1 or CCK2 receptor strongly activated the soluble adenylyl cyclase/cAMP/protein kinase A signaling pathway that drives sperm capacitation-associated protein tyrosine phosphorylation in dose-and time-dependent manners. But these actions of stimulation were abolished when sperm were incubated in the medium in the absence of HCO 3 K . Further investigation demonstrated that the inhibitor of CCK1 or CCK2 receptor could accelerate the uptake of HCO 3 K and significantly elevate the intracellular pH of sperm. Interestingly, the synthetic octapeptide of CCK (CCK8) showed the same action and mechanism as antagonists of CCK receptors. Moreover, CCK8 and the antagonist of CCK1 or CCK2 receptor were also able to accelerate human sperm capacitation-associated protein tyrosine phosphorylation by stimulating the influx of HCO 3 K . Thus, the present results suggest that CCK and its receptors may regulate sperm capacitation-associated protein tyrosine phosphorylation by modulating the uptake of HCO 3 K .Reproduction (2015) 150 257-268

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Expression of Cholecystokinin Type A Receptor Gene Correlates with DNA Demethylation during Postnatal Development of Rat Pancreas

Cited by 14 publications

References 16 publications

Promoter analysis of human cholecystokinin type-A receptor gene

Promoter analysis of human cholecystokinin type-A receptor gene

Importance of CCK-A Receptor for Gallbladder Contraction and Pancreatic Secretion: A Study in CCK-A Receptor Knockout Mice.

Cholecystokinin receptors regulate sperm protein tyrosine phosphorylation via uptake of HCO3−

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