Expression of Cell Cycle Regulatory Proteins and Analysis of Apoptosis in Normal Nasal Mucosa and in Nasal Polyps

Garavello, Werner; Viganò, Paola; Romagnoli, Marco; Sordo, Lorenza; Berti, Emilio; Tredici, G; Gaini, Renato Maria

doi:10.1177/194589240501900603

Cited by 15 publications

(15 citation statements)

References 23 publications

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“…In addition, Garavello et al . 15 and Chalastras et al . 14 showed higher Bcl-2 expression in NP using immunohistochemistry.…”

Section: Discussionmentioning

confidence: 93%

“…Cho et al 18 found no differences in XIAP expression between NP and control patients. In addition, Garavello et al 15 and Chalastras et al 14 showed higher Bcl-2 expression in NP using immunohistochemistry. Because Bcl-2 protein is an inhibitor of cytochrome c release, its increased expression could represent increased activity and, therefore, could lead to inhibition of caspase 9 production and changes in the intrinsic pathway of apoptosis.…”

Section: Discussionmentioning

confidence: 96%

“…Garavello et al . 15 reported p53 expression only in the mucosa, both normal and metaplastic, of CRSwNP patients.…”

mentioning

confidence: 99%

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Expression of Apoptosis Mediators p53 and Caspase 3, 7, and 9 in Chronic Rhinosinusitis with Nasal Polyposis

Küpper

Valera

Malinsky

et al. 2014

Am J Rhinol�Allergy

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“…In addition, Garavello et al . 15 and Chalastras et al . 14 showed higher Bcl-2 expression in NP using immunohistochemistry.…”

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Expression of Apoptosis Mediators p53 and Caspase 3, 7, and 9 in Chronic Rhinosinusitis with Nasal Polyposis

Küpper

Valera

Malinsky

et al. 2014

Am J Rhinol�Allergy

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“…Cellular growth seems to be dysregulated in polyps. A greater proportion of proliferating cells and increased apoptosis have been identified in the epithelial cells of polyps compared with normal mucosa [22]. …”

Section: Discussionmentioning

confidence: 99%

Increased Activation and Differentiated Localization of Native and Phosphorylated STAT3 in Nasal Polyps

Linke

Pries²,

Könnecke³

et al. 2013

Int Arch Allergy Immunol

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Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disease; the underlying mechanisms of cell signalling are not fully understood. STAT3 (signal transducer and activator of transcription 3) is a phosphokinase and a key signalling molecule implicated in cell cycle regulation. We studied the distribution and expression of STAT3 to examine the role of STAT3 in the pathogenesis of CRSwNP. Methods: We investigated tissue samples of the nasal polyps and inferior turbinate of patients with CRSwNP as well as samples of the inferior turbinate of subjects without chronic sinusitis. The expression levels of STAT3 and its activated form pSTAT3 were analysed using Western blotting, protein array, DNA microarray and immunohistochemistry. Results: No significant differences were found in STAT3-mRNA levels between the samples of nasal polyps and inferior turbinates of the same patient. However, the amount of pSTAT3 was increased in the polyp tissue compared to the inferior turbinates from both CRSwNP patients and control subjects (p < 0.01), indicating an activation of STAT3 in polyps. We identified a varying distribution pattern of pSTAT3; pSTAT3 was primarily found in superficial epithelial cells but not in the basal layer of the epithelium of the turbinate, whereas pSTAT3 was located in all layers of the epithelium of the polyp and mostly noted in the basal layer. Conclusions: Our results of the activation and varying localisation of STAT3 and its phosphorylated form in nasal polyps suggest that pSTAT3 plays a crucial role in the proliferative development of nasal polyps.

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“…The immunohistochemical protein expression patterns of cell-cycle-regulators p53, p21, p27 and proliferation marker Ki-67 have been studied in IP and sinonasal carcinoma, which gave clues to this progression [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of P53, P63, P21, P27, Ki-67 in Paranasal Sinus Squamous Cell Carcinoma and Inverted Papilloma

Öncel

Cosgul

Çallı

et al. 2011

Indian J Otolaryngol Head Neck Surg

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Using a molecular genetic approach, we try to confirm the molecular alterations of inverted papilloma and clarify its status as a putative precursor lesion of sinonasal squamous cell carcinoma. To better understand its genetics, we investigated the immunohistochemical protein expression patterns of cell-cycle-regulators p53, p63, p21, p27 and proliferation marker Ki-67 in 22 inverted papilloma and 9 squamous cell carcinoma of the sinonasal tract. Significantly elevated levels of p53 and p63 in squamous cell carcinoma of sinonasal tract compared with inverted papilloma were revealed. Ki-67-stained neoplastic cell nuclei were found in a significantly higher percentage of squamous cell carcinoma of sinonasal tract than in inverted papilloma, whereas no variation of p21 and p27 expression was identified. This work first examined the immunohistochemical overexpression of p63 in sinonasal inverted papilloma and squamous cell carcinoma. In conclusion, this is a first study shedding light on the expression of p63 in tumors of paranasal sinuses.

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Expression of Cell Cycle Regulatory Proteins and Analysis of Apoptosis in Normal Nasal Mucosa and in Nasal Polyps

Cited by 15 publications

References 23 publications

Expression of Apoptosis Mediators p53 and Caspase 3, 7, and 9 in Chronic Rhinosinusitis with Nasal Polyposis

Expression of Apoptosis Mediators p53 and Caspase 3, 7, and 9 in Chronic Rhinosinusitis with Nasal Polyposis

Increased Activation and Differentiated Localization of Native and Phosphorylated STAT3 in Nasal Polyps

Evaluation of P53, P63, P21, P27, Ki-67 in Paranasal Sinus Squamous Cell Carcinoma and Inverted Papilloma

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