Expression of CD44, CD44v9, ABCG2, CD24, Bmi‑1 and ALDH1 in stage I and II oral squamous cell carcinoma and their association with clinicopathological factors

Tamatani, Tetsuya; Takamaru, Natsumi; Ohe, Go; Akita, Kazuya; Nakagawa, Takayuki; Miyamoto, Youji

doi:10.3892/ol.2018.8703

Cited by 19 publications

(35 citation statements)

References 36 publications

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“…The presence of ALDH1 in cancer cells with a greater invasive capacity has already been described ( 11 , 22 , 23 ). Likewise, previous studies have reported the association between EMT and CSCs markers and ALDH1 expression in primary tumors and regional metastasis ( 12 , 13 , 24 - 26 ). This suggests that ALDH1 positivity can be associated to cells in the EMT process and, consequently, to metastasis ( 24 , 26 ).…”

Section: Discussionsupporting

confidence: 53%

Overexpression of ALDH1 and EMT marker profile are linked with unfavorable outcome in head and neck cancer

Vieira¹,

Campos²,

Jesus³

et al. 2020

Med Oral

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Background The aim of this research was to assess the expression of aldehyde dehydrogenase 1 (ALDH1) and epithelial-mesenchymal transition (EMT) markers in head and neck squamous cell carcinoma (HNSCC), and to correlate them with the clinical and histopathological parameters of a patient cohort with follow-up over an 8-year period. Material and Methods For this, seventeen HNSCC and non-neoplastic adjacent epithelium (AE) samples were subjected to laser microdissection and real-time PCR to evaluate the mRNA expression of ALDH1, E-cadherin (E-CAD), N-cadherin (N-CAD), and vimentin (VIM). Also, immunohistochemistry was performed for ALDH1, E-CAD, N-CAD, and VIM in the tumor center (TC), invasion front (IF), and AE of the seventeen samples. Mann-Whitney, Kruskal-Wallis and Chi-square tests were used to correlate the mRNA and immunohistochemical expression with different variables, considering p <0.05. Kaplan-Meier curves were produced for local recurrence, regional metastasis and treatment. Results A mRNA overexpression of ALDH1 in primary tumors was associated with regional metastasis and a high ALDH1 immunostaining was related to metastasis and a worse patient outcome. Additionally, a favorable outcome was associated with the transition phase and an unfavorable outcome was associated with EMT event. An overall 26.9 months was observed with longer survival associated with surgery and radiotherapy. Conclusions However, due to the intense variability inherent to the indicator proteins in the EMT process, the complete profile markers related to this biological process should be continuous investigated. Key words: Aldehyde dehydrogenase 1, epithelial mesenchymal transition, head and neck cancer, squamous cell carcinoma, follow-up study.

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Section: Discussionsupporting

confidence: 53%

Overexpression of ALDH1 and EMT marker profile are linked with unfavorable outcome in head and neck cancer

Vieira¹,

Campos²,

Jesus³

et al. 2020

Med Oral

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“…35 Assessment of ALDH with clinicopathologic parameters showed significant correlation with respect to site, histological grade, tumor size, and tumor staging. Michifuri et al 38 and Tamatani et al 39 also noted ALDH1 to be significantly associated with increasing histologic grades and lymph node metastasis. Chen et al noted ALDH1 expression to be increased in cases with OSCC showing lymph node metastasis.…”

Section: Discussionmentioning

confidence: 94%

Prognostic Significance of ALDH1, Bmi1, and OCT4 Expression in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma

Rao

Augustine

et al. 2020

Cancer Control

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Background: Increasing evidence suggests the involvement of cancer stem cells (CSCs) in both oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Among the various CSC markers, aldehyde dehydrogenase (ALDH) 1, B cell-specific Moloney murine leukaemia virus integration site 1 (Bmi1), and octamer-binding protein 4 (OCT4) have been noted to increase in OSCC. The aim of the study was to analyze ALDH1, Bmi1, and OCT4 expression in OED and OSCC with clinicopathologic correlation and survival analysis. Methods: A total of 40 cases each of OED and OSCC were retrieved from departmental archives. Expression of ALDH1, Bmi1, and OCT4 was analyzed using immunohistochemistry and was correlated with clinicopathological parameters. A follow-up ranging from 6 to 52 months was considered for Kaplan-Meier survival analysis. The log-rank test was performed to analyze significant difference in survival rates. Results: The expression levels of ALDH1, Bmi1, and OCT4 increased significantly from OED through OSCC ( P < .05). The expression of ALDH1 and OCT4 showed a significant correlation with lymph node metastasis. Positive cases of ALDH1 showed a significantly reduced survival rate compared to cases showing negative expression. Kaplan-Meier survival analysis showed a significant reduction of survival rate ( P = .00) in patients showing a positive expression for all the 3 markers. Conclusion: ALDH1 and OCT4 could be used as individual prognostic markers for assessing prognosis. ALDH1, Bmi1, and OCT4 could be used as a collective panel of markers to enable surgeons in predicting the prognosis of patients and thereby carry out prompt follow-up for such cases.

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“…The studies by Tamatani et al (44) and Hayry et al (72) showed a negative connection between BMI1 upregulation and tumor invasion, as well as overall survival rate. This can be due to the fact that these studies only investigated patients in the early stages of their disease.…”

Section: Bmi1mentioning

confidence: 92%

“…The presence of ALDH + cells is significantly correlated with the histopathologic differentiation of the malignant tumor (41)(42)(43). Interestingly, although ALDH1 + cells are scattered in the OSCC microenvironment, they are not found in the areas adjacent to the keratin pearls (44). High ALDH expression has also been linked with a decreased overall 5year survival of patients (43,44).…”

Section: Aldh1mentioning

confidence: 99%

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Cancer Stem Cells and Oral Carcinogenesis; a Review Article

Ghazi¹,

Ghazi

Ansari

et al. 2019

Int J Cancer Manag

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Context: Epithelial carcinogenesis is a multistep process. Transmission from normal oral epithelium to oral dysplasia and cancer is believed to result from several genetic alterations. Despite recent advances in the treatment approaches over the last decades, the mortality and morbidity rate of patients with oral squamous cell carcinoma (OSCC) has not been markedly improved. A small subset of cells, cancer stem cells (CSCs) with self-renewal properties, is a major focus of the current research. Here, we present a review of CSCs and their role in oral premalignant and malignant lesions, offering an insight into the stem cell markers, their putative role, and the means of targeting them in treatments. Evidence Acquisition: Using the main keywords of "cancer stem cell", "oral squamous cell carcinoma", and "cancer stem cell marker", a comprehensive search was done among several research databases. Results: Accumulating evidence supports the existence of CSCs as small subpopulations in OSCC, which are associated with tumor progression and therapy resistance. A number of cell surface markers have been used to identify these cells by various studies. Therefore, identifying a reliable CSC marker that is associated with OSCC seems to be necessary. Conclusions: The identification of the mechanisms underlying oral cancer initiation and progression is of the utmost importance. CSC markers that could act as a therapeutic target could play an important role in the effective treatment strategies of OSCC.

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Expression of CD44, CD44v9, ABCG2, CD24, Bmi‑1 and ALDH1 in stage I and II oral squamous cell carcinoma and their association with clinicopathological factors

Cited by 19 publications

References 36 publications

Overexpression of ALDH1 and EMT marker profile are linked with unfavorable outcome in head and neck cancer

Overexpression of ALDH1 and EMT marker profile are linked with unfavorable outcome in head and neck cancer

Prognostic Significance of ALDH1, Bmi1, and OCT4 Expression in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma

Cancer Stem Cells and Oral Carcinogenesis; a Review Article

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