Expression of CD44 and its variants on gastric epithelial cells of patients with Helicobacter pylori colonisation.

Fan, X. J.; Long, Aideen; Goggins, Michael; Keeling, P. W. N.; Kelleher, Dermot

doi:10.1136/gut.38.4.507

Cited by 31 publications

(22 citation statements)

References 26 publications

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“…MMP-9 and MMP-2 cleave latent transforming growth factor ␤ (TGF-␤) (10). These changes reflect alterations in cell-cell interactions and cell migration that support and extend previous findings from cell culture and clinical samples (31,32). Together they suggest participation by and interaction among tissue remodeling enzymes, cell surface receptors, and growth factors.…”

Section: Resultssupporting

confidence: 72%

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Gastric Transcription Profile of Helicobacter pylori Infection in the Rhesus Macaque

2004

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Infection with Helicobacter pylori is usually asymptomatic but sometimes progresses to peptic ulcer disease or gastric adenocarcinoma. The development of disease involves both host and bacterial factors. In order to better understand host factors in pathogenesis, we studied the gastric transcription profile of H. pylori infection in the rhesus macaque by using DNA microarrays. Significant changes were found in the expression of genes important for innate immunity, chemokines and cytokines, cell growth and differentiation, apoptosis, structural proteins, and signal transduction and transcription factors. This broad transcription profile demonstrated expected up-regulation of cell structural elements and the host inflammatory and immune response, as well as the novel finding of down-regulation of heat shock proteins. These results provide a unique view of acute H. pylori infection in a relevant animal model system and will direct future studies regarding the host response to H. pylori infection.

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Section: Resultssupporting

confidence: 72%

“…ICAM-5 has previously been associated with expression in neuronal tissue (55). CD44 and ICAM-1 (31). CD44 expression was decreased at 24 weeks postinfection as were the integrins ␣3 and ␣L (CD11A).…”

Section: Resultsmentioning

confidence: 92%

Gastric Transcription Profile of Helicobacter pylori Infection in the Rhesus Macaque

2004

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“…CD44 is highly expressed in gastric cancer cell lines (32), H. pylori-infected human patient epithelia (32,33), gastric carcinomas (34,35), intestinal metaplasia (35,36), and dysplasia (37). Although CD44 is expressed in gastric tumors (32,33,38), its expression has not been characterized in normal mouse corpus gastric epithelial tissue (39), but it has been observed in the antral epithelium (32) and at the squamous-corpus junction (40). We found that CD44 was expressed throughout the scant interglandular mesenchymal cells (supplemental Fig.…”

Section: Cd44 Is Expressed In Isthmal Cells and Regulates Normalmentioning

confidence: 99%

The Hyaluronic Acid Receptor CD44 Coordinates Normal and Metaplastic Gastric Epithelial Progenitor Cell Proliferation

Khurana

Riehl

Moore

et al. 2013

Journal of Biological Chemistry

103

106

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Background: Gastric parietal cell atrophy causes metaplasia, reactive stem cell proliferation, and increased risk for cancer. Results: Atrophy induces proliferation of CD44-positive epithelial cells that requires ERK 3 CD44 3 STAT3 signaling. Conclusion: CD44 is a putative gastric stem cell marker that regulates normal and metaplasia-associated proliferation. Significance: Targeted pharmacological inhibition of ERK/CD44/STAT3 signaling may help block or reverse proliferation in precancerous atrophic/metaplastic lesions.

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“…We and others reported that CD44 is expressed following H. pylori infection in patients and in mouse models in the case of regenerative hyperplasia, intestinal metaplasia, dysplasia, and gastric carcinoma (Figure 2) [35, 36,50,51,65]. Histological and molecular analyses of tumor collections have shown that CD44 is positively and signiicantly associated with tumor recurrence and mortality in gastric cancer, and the expression of CD44 and CD44v has also been associated with metastasis formation [57,[65][66][67][68][69][70].…”

Section: Phenotypic Characterization Of Gastric Cancer Stem Cellsmentioning

confidence: 99%

Gastric Cancer: A Stem Cell Disease?

Giraud¹,

Bessède²,

Mégraud³

et al. 2017

Gastric Cancer

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Gastric stem cells have been recently identiied and are not yet fully characterized. Each gastric gland or unit is composed of diferent specialized cells and a small number of discrete stem cells. These gastric stem cells play key roles. They have self-renewal and multipotent properties and are the origin of specialized gastric epithelial cells. These properties are the basis for the stem cells' role in tissue homeostasis, tissue repair, and cancer. In tumors, growing evidence indicates that a cell subpopulation with stem cell features, the so-called cancer stem cells (CSCs), represents the "fuel" for the tumor: they are at the origin of tumor initiation, growth, and dissemination, and they also display resistance to conventional chemotherapy treatments. The recent identiication of CSCs in gastric carcinoma opens the door to the development of new therapeutic strategies targeting more speciically the CSCs at the origin of the disease, which is the third leading cause of cancer-related deaths worldwide.

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Expression of CD44 and its variants on gastric epithelial cells of patients with Helicobacter pylori colonisation.

Abstract: Background-Studies have suggested that expression of the adhesion molecule CD44 may be of prognostic importance in gastric cancer. In addition, there is strong

Cited by 31 publications

References 26 publications

Gastric Transcription Profile of Helicobacter pylori Infection in the Rhesus Macaque

Gastric Transcription Profile of Helicobacter pylori Infection in the Rhesus Macaque

The Hyaluronic Acid Receptor CD44 Coordinates Normal and Metaplastic Gastric Epithelial Progenitor Cell Proliferation

Gastric Cancer: A Stem Cell Disease?

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