Expression of CD34 antigen in testicular mixed germ cell tumor

Hamazaki, Shuji; Okada, Shigeru

doi:10.1046/j.1440-1827.2003.01566.x

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…Chou et al ( 9) previously reported on expression of CD34 in 5/15 prepubertal testicular GCT, all of which were YST, while no expression of this marker was found in 10 adult tumors consisting of different nonseminoma tumors. In contrast, Hamazaki and Okada (10) detected CD34 in 7/12 testicular YST, in a cohort in which all but one patient were adults. Our data are in agreement with the latter study.…”

Section: Discussionmentioning

confidence: 78%

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Cancer Stem Cell Markers Are Differentially Expressed in Malignant Ovarian Germ Cell Tumors

Davidson

Solheim

2023

International Journal of Gynecological Pathology

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The objective of this study was to analyze the expression and potential clinical role of cancer stem cell (CSC) markers in malignant ovarian germ cell tumors (MOGCT). CD34, CD44, and SOX2 protein expression by immunohistochemistry was analyzed in 49 MOGCT from patients treated in Norway during the period 1980-2011. Expression was analyzed for association with tumor type and clinicopathologic parameters. Tumors were diagnosed as dysgerminoma (DG; n=15), immature teratoma (IT; n=15), yolk sac tumor (YST; n=12), embryonal carcinoma (n=2), and mixed MOGCT (n=5). Tumor cell CD34 expression was significantly more common in YST, whereas stromal expression was only seen in IT (both P<0.001). CD44 was infrequently expressed, most often focally, in tumor cells, particularly in YST (P=0.026). CD44 was widely expressed in leukocytes, most prominently in DG. SOX2 was most frequently expressed in IT, with predominantly focal expression in some YST and uniform absence in DG (P<0.001). Stromal CD34 (P=0.012) and tumor cell SOX2 expression (P=0.004) were negatively associated with the involvement of the ovarian surface, presumably due to the low incidence of this event in IT. No significant association was found between CSC marker expression and other clinicopathologic parameters, including age, laterality, tumor diameter, and FIGO stage. In conclusion, CSC markers are differentially expressed in various MOGCT types, suggesting differences in the regulation of cancer-related processes. Expression of CD34, CD44, and SOX2 does not appear to be associated with clinical parameters in this patient group.

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Section: Discussionmentioning

confidence: 78%

“…Expression of CD34 and CD44 has been reported in testicular GCT (9)(10)(11)(12), but has not, to the best of our knowledge, been studied in MOGCT. The current study analyzed the expression of these markers in a series of 49 tumors.…”

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confidence: 94%