Expression of CC Chemokine Receptor-7 and Regional Lymph Node Metastasis of B16 Murine Melanoma

Wiley, Henry; Gonzalez, Erik B.; Maki, Wusi C.; Wu, Meng; Hwang, Samuel T

doi:10.1093/jnci/93.21.1638

Cited by 356 publications

(309 citation statements)

References 32 publications

(24 reference statements)

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“…For instance CXCL12, the ligand for CXCR4, is strongly expressed in lung, liver, bone marrow and lymph nodes while CCL21, the ligand for CCR7, is strongly expressed in lymph nodes [52]. In a melanoma model, transfection of CCR7 promotes lymph node metastases while transfection of CXCR4 promotes lung metastases [53,54]. These data indirectly support the absence of relationship between axillary lymph node involvement and detection of circulating breast cancer cells.…”

Section: Discussionmentioning

confidence: 94%

Detection of human mammaglobin mRNA in serial peripheral blood samples from patients with non-metastatic breast cancer is not predictive of disease recurrence

Marques

Teixeira

Diamond

et al. 2008

Breast Cancer Res Treat

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International audienceHuman mammaglobin (hMAM) mRNA is a sensitive and specific marker of breast cancer cells. We evaluated if hMAM mRNA detection in serial peripheral blood samples from non-metastatic breast cancer patients predicts for disease recurrence. Patients scheduled for adjuvant or neoadjuvant chemotherapy were eligible. Serial blood samples were collected up to 5 years, the first before (neo)adjuvant chemotherapy. hMAM gene expression was analysed by RT-PCR. Specificity was evaluated in blood samples from healthy volunteers. A total of 321 patients were included. The incidence of pre-chemotherapy hMAM-positive samples was similar in patients who latter experienced cancer recurrence (22.4%) and those who remained disease-free (17.9%; = 0.46). Similarly, the mean number of positive follow-up samples was similar in both groups (0.15 ± 0.22 and 0.13 ± 013; = 0.29). Furthermore, there was no difference in disease-free (= 0.63) or overall survival (= 0.57) in patients with and without positive baseline samples or between patients whose follow-up samples were always hMAM negative and those with at least one positive sample. Multivariate survival analysis confirmed that hMAM mRNA detection before or after (neo)adjuvant chemotherapy was not predictive of recurrence. There is no evidence that hMAM mRNA detection at diagnosis or during follow-up predicts for breast cancer recurrence

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Section: Discussionmentioning

confidence: 94%

Detection of human mammaglobin mRNA in serial peripheral blood samples from patients with non-metastatic breast cancer is not predictive of disease recurrence

Marques

Teixeira

Diamond

et al. 2008

Breast Cancer Res Treat

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“…It was also reported that Caco 2 metastasized to LNs at a low frequency (1/10) with a cecal CXCR3 in colon cancer metastasis to lymph nodes K Kawada et al transplantation model (Flatmark et al, 2004). Recent studies showed that CCR7 was involved in LN metastasis in breast and stomach cancers, and melanoma (Mu¨ller et al, 2001;Wiley et al, 2001;Mashino et al, 2002). Among the colon cancer cell lines tested by RT-PCR and flow cytometry, however, we found expression of CCR7 only in SW480 and Caco2 that rarely metastasized to LNs (Figure 1b and c).…”

Section: Expression Of Chemokine Receptors Cxcr3 Cxcr4 and Ccr7 In Cmentioning

confidence: 97%

Chemokine receptor CXCR3 promotes colon cancer metastasis to lymph nodes

et al. 2007

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Chemokines and their receptors are essential for leukocyte trafficking, and also implicated in cancer metastasis to specific organs. We have recently demonstrated that CXCR3 plays a critical role in metastasis of mouse melanoma cells to lymph nodes. Here, we show that some human colon cancer cell lines express CXCR3 constitutively. We constructed cells that expressed CXCR3 cDNA ('DLD-1-CXCR3'), and compared with nonexpressing controls by rectal transplantation in nude mice. Although both cell lines disseminated to lymph nodes at similar frequencies at 2 weeks, DLD-1-CXCR3 expanded more rapidly than the control in 4 weeks. In 6 weeks, 59% of mice inoculated with DLD1-CXCR3 showed macroscopic metastasis in para-aortic lymph nodes, whereas only 14% of those with the control (Po0.05). In contrast, metastasis to the liver or lung was rare, and unaffected by CXCR3 expression. In clinical colon cancer samples, we found expression of CXCR3 in 34% cases, most of which had lymph node metastasis. Importantly, patients with CXCR3-positive cancer showed significantly poorer prognosis than those without CXCR3, or those expressing CXCR4 or CCR7. These results indicate that activation of CXCR3 with its ligands stimulates colon cancer metastasis preferentially to the draining lymph nodes with poorer prognosis.

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“…breast, melanoma, gastric, non-small cell lung cancer, head and neck tumors, colorectal carcinoma), CCR7 is upregulated and mediates tumor cell dissemination to lymph nodes [101][102][103][104][105][106]. In a recent study, brain infiltration by T-cell leukemic blasts was mediated by CCR7 [15].…”

Section: Tumor Cell Invasion and Migration To Distant Organsmentioning

confidence: 99%

Chemokines in cancer related inflammation

Allavena

Germano

Marchesi

et al. 2011

Experimental Cell Research

199

140

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Chemokines are key players of the cancer-related inflammation. Chemokine ligands and receptors are downstream of genetic events that cause neoplastic transformation and are abundantly expressed in chronic inflammatory conditions which predispose to cancer. Components of the chemokine system affect multiple pathways of tumor progression including: leukocyte recruitment, neo-angiogenesis, tumor cell proliferation and survival, invasion and metastasis.Evidence in pre-clinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies

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Expression of CC Chemokine Receptor-7 and Regional Lymph Node Metastasis of B16 Murine Melanoma

Abstract: Expression of a single chemokine receptor gene, CCR7, increased B16 cell metastasis to draining lymph nodes, suggesting that cancer cells may co-opt normal mechanisms of lymph node homing during metastasis.

Cited by 356 publications

References 32 publications

Detection of human mammaglobin mRNA in serial peripheral blood samples from patients with non-metastatic breast cancer is not predictive of disease recurrence

Detection of human mammaglobin mRNA in serial peripheral blood samples from patients with non-metastatic breast cancer is not predictive of disease recurrence

Chemokine receptor CXCR3 promotes colon cancer metastasis to lymph nodes

Chemokines in cancer related inflammation

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