Expression of candidate plasticity-related gene 15 is increased following traumatic brain injury

He, Yalong; Yang, Guitao; Wang, Yangang; Ren, Yi; He, Xiaosheng; Zhang, Xiang; Fei, Zhou

doi:10.1179/1743132812y.0000000134

Cited by 12 publications

(2 citation statements)

References 23 publications

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“…It is highly expressed in the developing nervous system, with the level decreasing upon maturation (Naeve et al, 1997). However, Neuritin is upregulated in adult neural structures, such as the olfactory bulb, hippocampus, visual cortex, and Purkinje fibers (Nedivi et al, 1996, 2001; Yamagata et al, 1998) as well as during transient global ischemia, traumatic brain injury, spinal cord injury, and androgen treatment (Di Giovanni et al, 2005b; Han et al, 2007; Fargo et al, 2008; He et al, 2013). The latter was shown to promote functional recovery of injured facial nerves, which was associated with Neuritin upregulation; conversely, blocking androgen reduced Neuritin expression, suggesting a correlation between Neuritin, and functional recovery of injured facial nerves (Fargo et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Recombinant hNeuritin Promotes Structural and Functional Recovery of Sciatic Nerve Injury in Rats

Wang

Shan

et al. 2016

Front. Neurosci.

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Neuritin is a new neurotropic factor implicated in nervous system development and plasticity. Studies have shown that Neuritin is upregulated in injured nerves, suggesting that it is involved in nerve repair. To test this hypothesis, we investigated whether recombinant human Neuritin could restore nerve structure and function in a rat model of sciatic nerve injury. Neuritin treatment had a dose-dependent effect on functional recovery 4 weeks after injury, as determined by the walking-track test. Similar trends were observed for gastrocnemius muscular strength and nerve conduction velocity. Additionally, sciatic nerve fiber density and organization as well as degree of remyelination were increased, while growth-associated protein 43 and neurofilament 200 expression was upregulated upon treatment with Neuritin. These findings demonstrate that Neuritin stimulates nerve regeneration and functional recovery and thus promotes the repair of injured sciatic nerves.

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Section: Introductionmentioning

confidence: 99%

Recombinant hNeuritin Promotes Structural and Functional Recovery of Sciatic Nerve Injury in Rats

Wang

Shan

et al. 2016

Front. Neurosci.

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“…In addition, neuritin was found to signi cantly promote the growth and branching of neural processes, enhance the maturation of synapses, increase the number and length of synaptic connections [19], promote the establishment of functional synaptic connections [20], and contribute to the survival of neurons by inhibiting apoptosis [21,22]. Neuritin expression in the damaged site was consistent with functional recovery during nerve injury repair, suggesting that its expression was related to structural and functional repair of the damaged site [23].…”

Section: Introductionmentioning

confidence: 91%

Neuritin restores auditory following cochlear spiral ganglion neuron denervation of gerbils

Gui

Song

Wang

et al. 2023

Preprint

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Spiral ganglion neurons (SGNs) transmit sound signals received by hair cells to the auditory center to produce hearing. The quantity and function are important for maintaining normal hearing function. Limited by the regenerative capacity, SGNs are unable to regenerate spontaneously after injury. Various neurotrophic factors play an important role in the regeneration process. Neuritin, a neurite outgrowth factor, is a neurotrophic factor closely related to neural plasticity. In this study, we used bioinformatics analysis to show that neuritin was negatively correlated with cochlear damage. Then, we aimed to establish a cochlear spiral ganglion-specific sensorineural deafness model in gerbils using ouabain and determine the effects of exogenous neuritin protein in protecting damaged cochlear SGNs and repairing damaged auditory nerve function. The provides a new research strategy and scientific basis for the prevention and treatment of sensorineural deafness caused by the loss of SGNs. We found that neuritin is expressed throughout the development of the gerbil cochlea, primarily in the SGNs and Corti regions. The expression of neuritin was negatively correlated with the sensorineural deafness model. In vitro and in vivo revealed that neuritin significantly maintained the number and arrangement of SGNs and nerve fibers in the damaged cochlea and effectively protected the high-frequency listening function of gerbils.

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Neuritin improves the neurological functional recovery after experimental intracerebral hemorrhage in mice

Zhao

et al. 2021

Neurobiology of Disease

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Expression of candidate plasticity-related gene 15 is increased following traumatic brain injury

Cited by 12 publications

References 23 publications

Recombinant hNeuritin Promotes Structural and Functional Recovery of Sciatic Nerve Injury in Rats

Recombinant hNeuritin Promotes Structural and Functional Recovery of Sciatic Nerve Injury in Rats

Neuritin restores auditory following cochlear spiral ganglion neuron denervation of gerbils

Neuritin improves the neurological functional recovery after experimental intracerebral hemorrhage in mice

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