Expression of Cancer-Testis Genes Prame, Ny-Eso1, Gage1, Mage A3, Mage A6, Mage A12, Ssx1, Sllp1, Pasd1 in Patients With Multiple Myeloma, Their Influence on Overall Survival and Relapse Rate

Abstract

Objective:to study the prognostic significance of the expression of cancer-testis (CT) genes PRAME, NY-ESO1, GAGE1, MAGE A3, MAGE A6, MAGE A12, SSX1, SLLP1, PASD1 in patients with multiple myeloma (MM) and their influence on overall survival and relapse rate. To determine their effect on suсh clinical parameters as levels of lactate dehydrogenase, leucocytes, hemoglobin, calcium, albumen, creatinine, beta-2-microglobulin.Materials and methods.Real-time polymerase chain reaction was performed on complementary DNA obtained from bone marrow of 77 patients with MM. The statistical analysis was performed using the Statistica 10.0 software package. To estimate prognostic values of the CT gene expression data were analyzed by the Kaplan – Meier method.Results.The study was conducted to determine the level of expression of CT genes PRAME, NY-ESO1, GAGE1, MAGE A3, MAGE A6, MAGE A12, SSX1, SLLP1, PASD1 in a group of patients with MM. The group included primary and receiving cancer treatment in MM patients. According to the log-rank criterion expression of any of the CT genes PRAME, NY-ESO1, GAGE1, MAGE A3, MAGE A6, MAGE A12, SSX1, SLLP1, PASD1 exerts a significant influence on overall survival and progression-free survival/relapse. It was also determined that providing expression of some CT genes, the levels of creatinine, calcium, beta-2-microglobulin were much higher to compare with patients without expression.

Prognostic Value of PRAME Activity in Tumor Cells of Follicular Lymphoma

“…Причина заключается в бортезомиб-опосредованной отмене некоторых функций белка PRAME. Действительно, независимые наблюдения показывают, насколько эффективным оказался данный подход при лечении множественной миеломы [18]. Интересно, что на ресурсе clinicaltrials.gov к настоящему моменту (июль 2018 г.)…”