Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer

Custódio, Marcos; Pelissari, Cibele; Santana, Thalita; Trierveiler, Marília

doi:10.1007/s00405-018-5002-8

Cited by 12 publications

(8 citation statements)

References 29 publications

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“…ALDH1 is associated with tumor malignancy and self-renewal properties of stem cells in HNCs ( 182 ) and has been associated with poorer prognosis and failure of chemoradiotherapy in HNCs ( 13 , 183 ). ALDH1 acts as a stem cell marker for HNCs such as oral cancer ( 184 ), eyelid sebaceous gland carcinoma ( 185 ), benign epithelial odontogenic lesions ( 186 ), salivary gland tumor ( 187 , 188 ), lip cancer ( 189 ), sublingual adenoma ( 190 ).…”

Section: Aldh1 and Various Solid Tumorsmentioning

confidence: 99%

ALDH1: A potential therapeutic target for cancer stem cells in solid tumors

Wei

Chen

et al. 2022

Front. Oncol.

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Solid tumors can be divided into benign solid tumors and solid malignant tumors in the academic community, among which malignant solid tumors are called cancers. Cancer is the second leading cause of death in the world, and the global incidence of cancer is increasing yearly New cancer patients in China are always the first. After the concept of stem cells was introduced in the tumor community, the CSC markers represented by ALDH1 have been widely studied due to their strong CSC cell characteristics and potential to be the driving force of tumor metastasis. In the research results in the past five years, it has been found that ALDH1 is highly expressed in various solid cancers such as breast cancer, lung cancer, colorectal cancer, liver cancer, gastric cancer, cervical cancer, esophageal cancer, ovarian cancer, head,and neck cancer. ALDH1 can activate and transform various pathways (such as the USP28/MYC signaling pathway, ALDH1A1/HIF-1α/VEGF axis, wnt/β-catenin signaling pathway), as well as change the intracellular pH value to promote formation and maintenance, resulting in drug resistance in tumors. By targeting and inhibiting ALDH1 in tumor stem cells, it can enhance the sensitivity of drugs and inhibit the proliferation, differentiation, and metastasis of solid tumor stem cells to some extent. This review discusses the relationship and pathway of ALDH1 with various solid tumors. It proposes that ALDH1 may serve as a diagnosis and therapeutic target for CSC, providing new insights and new strategies for reliable tumor treatment.

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Section: Aldh1 and Various Solid Tumorsmentioning

confidence: 99%

ALDH1: A potential therapeutic target for cancer stem cells in solid tumors

Wei

Chen

et al. 2022

Front. Oncol.

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“…CD44 expression in OSCC samples even showed a diminished rate (53). Another study on actinic cheilitis demonstrated that while the expression increases both in intensity and extent with dysplastic severity, cell distinction using CD44 is not easily possible in different tissue conditions (54). Several studies report that different CD44 variants are associated with higher grades, higher drug resistance, and poor prognosis in head and neck SCC (52,(55)(56)(57).…”

Section: Cd44mentioning

confidence: 99%

“…CD271 is found basically on neurons, and it was later found to be a marker for stem cells (76). More recently, it has been proposed as a putative CSC marker in the oral dysplastic and malignant epithelium (mostly in conjunction with other markers such as CD44 and ALDH1) (40,54). Some studies on the expression of p75NTR have shown that its staining pattern does not differ much between normal oral mucosa and dysplastic lesions, being confined to the basal layer (40,77).…”

Section: P75ntrmentioning

confidence: 99%

Cancer Stem Cells and Oral Carcinogenesis; a Review Article

Ghazi¹,

Ghazi

Ansari

et al. 2019

Int J Cancer Manag

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Context: Epithelial carcinogenesis is a multistep process. Transmission from normal oral epithelium to oral dysplasia and cancer is believed to result from several genetic alterations. Despite recent advances in the treatment approaches over the last decades, the mortality and morbidity rate of patients with oral squamous cell carcinoma (OSCC) has not been markedly improved. A small subset of cells, cancer stem cells (CSCs) with self-renewal properties, is a major focus of the current research. Here, we present a review of CSCs and their role in oral premalignant and malignant lesions, offering an insight into the stem cell markers, their putative role, and the means of targeting them in treatments. Evidence Acquisition: Using the main keywords of "cancer stem cell", "oral squamous cell carcinoma", and "cancer stem cell marker", a comprehensive search was done among several research databases. Results: Accumulating evidence supports the existence of CSCs as small subpopulations in OSCC, which are associated with tumor progression and therapy resistance. A number of cell surface markers have been used to identify these cells by various studies. Therefore, identifying a reliable CSC marker that is associated with OSCC seems to be necessary. Conclusions: The identification of the mechanisms underlying oral cancer initiation and progression is of the utmost importance. CSC markers that could act as a therapeutic target could play an important role in the effective treatment strategies of OSCC.

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“…[17] Although many studies have inspected the effect of UV light on the skin, very few studies have investigated the mechanisms of AC and SCC development. [18][19][20][21][22] Thus, it is important to understand the mechanism underlying the development of SCC. This study aims to investigate nuclear expressions of p16 INK4a , p14 ARF , and p53 in normal lip mucosa, AC, and SCC of the lip, and therefore, to determine the potential importance of these markers in early carcinogenesis, as well as their relationship with histopathological prognostic factors.…”

Section: Introductionmentioning

confidence: 99%

p16 INK4a , and p14 ARF Expressions in Carcinogenesis of Squamous Cell Carcinoma of the Lip

Akatlı¹,

Ayva²,

Bozdoğan³

2022

Clin Cancer Investig J

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The goal of this study was to clarify the role of p16 INK4a , p14 ARF, and p53 protein expressions in carcinogenesis in squamous cell carcinomas of the lip. The expressions of the p53, p16 INK4a , and p14 ARF proteins were examined in 46 formaline-fixed paraffin embedded tissue specimens, which included 19 cases of squamous cell carcinoma of the lip, 14 cases of actinic cheilitis, and 13 cases of normal mucosa. Immunoreactivity in the peritumoral epithelium adjacent to squamous cell carcinomas was also evaluated. p16 INK4a expression was increased in actinic cheilitis in comparison with normal mucosa (p=0.001). p14 ARF expression progressively increased from normal mucosa to actinic cheilitis (p=0.001) and was observed to decrease significantly during the process of transition from actinic cheilitis to carcinoma (p=0.003). p53 values progressively increased from normal mucosa to actinic cheilitis (p=0.001) and carcinoma (p=0.008). A significant positive correlation was found between p14 ARF and p53 in the peritumoral epithelium adjacent to carcinomas. Our findings indicated that p16 INK4a and p14 ARF immunohistochemistry does not determine whether or not actinic cheilitis has the potential to develop carcinoma. The p14 ARF /p53 pathway is activated in the peritumoral epithelium adjacent to carcinoma; however, this activation would not be adequate to prevent carcinogenesis.

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Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer

Abstract: CSC markers are expressed in potentially malignant and malignant lesions of the lip. Their expressions were invariable between AC and LSCC and unrelated to p53. p75NTR expression increased with the worsening of epithelial dysplasia grade.

Cited by 12 publications

References 29 publications

ALDH1: A potential therapeutic target for cancer stem cells in solid tumors

ALDH1: A potential therapeutic target for cancer stem cells in solid tumors

Cancer Stem Cells and Oral Carcinogenesis; a Review Article

p16 INK4a , and p14 ARF Expressions in Carcinogenesis of Squamous Cell Carcinoma of the Lip

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