Expression of calbindin‐D28k and parvalbumin during development of rat's basolateral amygdaloid complex

Berdel, B; Moryś, Janusz

doi:10.1016/s0736-5748(00)00024-1

Cited by 59 publications

(71 citation statements)

References 70 publications

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“…However, the current study is the first to demonstrate directly the age bias in the effects of stress on GABAergic regulation of LAT neurons. In rats, BLA parvalbumin-positive interneurons reach maturity at~PND 30 (Berdel and Morys, 2000;Legaz et al, 2005;Davila et al, 2008), which overlapped with the start of our repeated restraint protocol during adolescence. Repeated stress may stunt the final phases of prepubertal GABAergic development leading to greater impact of stress on GABAergic systems in adolescence.…”

Section: Discussionmentioning

confidence: 91%

“…The GABAergic system in the BLA is still developing during the first several weeks postnatal. In rodents, the GABAergic interneuron network and basic GABAergic IPSC kinetics do not reach maturity until~PND 14-28 (Berdel and Morys, 2000;Legaz et al, 2005;Olmos et al, 2005;Davila et al, 2008;Ehrlich et al, 2013). GABA also appears to exert differences in inhibitory regulation at later ages.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Repeated Stress on Age-Dependent GABAergic Regulation of the Lateral Nucleus of the Amygdala

Zhang

Rosenkranz

2016

Neuropsychopharmacol

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The adolescent age is associated with lability of mood and emotion. The onset of depression and anxiety disorders peaks during adolescence and there are differences in symptomology during adolescence. This points to differences in the adolescent neural circuitry that underlies mood and emotion, such as the amygdala. The human adolescent amygdala is more responsive to evocative stimuli, hinting to less local inhibitory regulation of the amygdala, but this has not been explored in adolescents. The amygdala, including the lateral nucleus (LAT) of the basolateral amygdala complex, is sensitive to stress. The amygdala undergoes maturational processes during adolescence, and therefore may be more vulnerable to harmful effects of stress during this time period. However, little is known about the effects of stress on the LAT during adolescence. GABAergic inhibition is a key regulator of LAT activity. Therefore, the purpose of this study was to test whether there are differences in the local GABAergic regulation of the rat adolescent LAT, and differences in its sensitivity to repeated stress. We found that LAT projection neurons are subjected to weaker GABAergic inhibition during adolescence. Repeated stress reduced in vivo endogenous and exogenous GABAergic inhibition of LAT projection neurons in adolescent rats. Furthermore, repeated stress decreased measures of presynaptic GABA function and interneuron activity in adolescent rats. In contrast, repeated stress enhanced glutamatergic drive of LAT projection neurons in adult rats. These results demonstrate age differences in GABAergic regulation of the LAT, and age differences in the mechanism for the effects of repeated stress on LAT neuron activity. These findings provide a substrate for increased mood lability in adolescents, and provide a substrate by which adolescent repeated stress can induce distinct behavioral outcomes and psychiatric symptoms.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Effects of Repeated Stress on Age-Dependent GABAergic Regulation of the Lateral Nucleus of the Amygdala

Zhang

Rosenkranz

2016

Neuropsychopharmacol

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“…While the amygdala continues to develop through adolescence, nuclei are distinct by P7 and responsive to olfactory information during the early neonatal period (Schwob et al, 1984;Berdel et al, 1997;Morys et al, 1999;Nair and Gonzalez-Lima, 1999;Berdel and Morys, 2000;Bouwmeester et al, 2002;Wilson, 2003). However, at this age, minimal connections exist between the amygdala and other brain areas considered important in fear conditioning, such as the prefrontal cortex and hippocampus (Nair and Gonzalez-Lima, 1999;Bouwmeester et al, 2002).…”

Section: Methodsmentioning

confidence: 99%

Dual Circuitry for Odor-Shock Conditioning during Infancy: Corticosterone Switches between Fear and Attraction via Amygdala

Moriceau

Wilson

Levine

et al. 2006

Journal of Neuroscience

207

231

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Rat pups must learn maternal odor to support attachment behaviors, including nursing and orientation toward the mother. Neonates have a sensitive period for rapid, robust odor learning characterized by increased ability to learn odor preferences and decreased ability to learn odor aversions. Specifically, odor-0.5 mA shock association paradoxically causes an odor preference and coincident failure of amygdala activation in pups until postnatal day 10 (P10). Because sensitive-period termination coincides with a declining "stress hyporesponsive period" when corticosterone release is attenuated, we explored the role of corticosterone in sensitive-period termination. Odor was paired with 0.5 mA shock in either sensitive-period (P8) or postsensitive-period (P12) pups while manipulating corticosterone. We then assessed preference/aversion learning and the olfactory neural circuitry underlying its acquisition. Although sensitive-period control paired odor-shock pups learned an odor preference without amygdala participation, systemic (3 mg/kg, i.p.; 24 h and 30 min before training) or intra-amygdala corticosterone (50 or 100 ng; during training) permitted precocious odor-aversion learning and evoked amygdala neural activity similar to that expressed by older pups. In postsensitive-period (P12) pups, control paired odor-shock pups showed an odor aversion and amygdala activation, whereas corticosterone-depleted (adrenalectomized) paired odor-shock pups showed odor-preference learning and activation of an odor learning circuit characteristic of the sensitive period. Intra-amygdala corticosterone receptor antagonist (0.3 ng; during training) infused into postsensitive-period (P12) paired odor-shock pups also showed odor-preference learning. These results suggest corticosterone is important in sensitive-period termination and developmental emergence of olfactory fear conditioning, acting via the amygdala as a switch between fear and attraction. Because maternal stimulation of pups modulates the pups' endogenous corticosterone, this suggests maternal care quality may alter sensitive-period duration.

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“…2, available at www.jneurosci.org as supplemental material). A recent study has suggested that parvalbumin-positive interneurons in the rat BLA undergo significant developmental changes in their distribution and morphology between the ages of postnatal day 21 (P21) and P30 (Berdel and Morys, 2000). Our studies have been limited to animals aged P16 -P25 with most experiments being done on animals aged around P16 -P18.…”

Section: Identification and Classification Of Pv؉ Interneuronsmentioning

confidence: 99%

Networks of Parvalbumin-Positive Interneurons in the Basolateral Amygdala

Woodruff¹,

Sah²

2007

J. Neurosci.

194

228

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The amygdala is a temporal lobe structure that is required for processing emotional information. Polymodal sensory information enters the amygdala at the level of the basolateral amygdala (BLA) and undergoes local processing, after which the behavioral and autonomic responses that accompany emotions are initiated. Two main neuron types are present in the BLA, pyramidal-like principal neurons that use glutamate as their transmitter, and local circuit interneurons that use GABA as their transmitter. Although the properties of principal neurons are known in some detail, very little is known about the properties of BLA interneurons or the local circuits in which they are involved. Using mice in which EGFP (enhanced green fluorescent protein) is expressed under the control of the parvalbumin promoter, we characterized the properties of parvalbumin-positive interneurons in the BLA. By making recordings from interneuron-interneuron and interneuron-principal neuron pairs, we analyzed the intrinsic circuitry of the BLA. We show that parvalbumin-positive interneurons can be divided into four subtypes as defined by their firing properties. Interneurons are electrically coupled in subtype-specific networks and exhibit subtype-specific heterogeneities in their synaptic dynamics and patterns of connectivity. We propose that these properties allow networks of parvalbumin-expressing neurons to perform an array of information-processing tasks within the BLA.

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Expression of calbindin‐D28k and parvalbumin during development of rat's basolateral amygdaloid complex

Cited by 59 publications

References 70 publications

Effects of Repeated Stress on Age-Dependent GABAergic Regulation of the Lateral Nucleus of the Amygdala

Effects of Repeated Stress on Age-Dependent GABAergic Regulation of the Lateral Nucleus of the Amygdala

Dual Circuitry for Odor-Shock Conditioning during Infancy: Corticosterone Switches between Fear and Attraction via Amygdala

Networks of Parvalbumin-Positive Interneurons in the Basolateral Amygdala

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