Expression of c-Fos, ICER, Krox-24 and JunB in the whisker-to-barrel pathway of rats: time course of induction upon whisker stimulation by tactile exploration of an enriched environment

Bisler, S.; Schleicher, Axel; Gass, Peter; Stehle, Jörg H.; Zilles, Karl; Staiger, Jochen F.

doi:10.1016/s0891-0618(01)00155-7

Cited by 94 publications

(85 citation statements)

References 49 publications

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“…For instance, Btg2 is involved in neuronal differentiation (Bradbury et al, 1991) and plays a crucial role in contextual memory (Farioli-Vecchioli et al, 2008, 2009). The upregulation of Crem during EE confirms previous observations, also in barrel cortex (Bisler et al, 2002), supporting its key role in neuronal plasticity (Mioduszewska et al, 2003). Fos and Jun induce expression of Bdnf (Zhang et al, 2002), one of the pivotal molecules in neuronal plasticity (Greenberg et al, 2009).…”

Section: Discussionsupporting

confidence: 86%

“…Passive whisker stimulation increases brain-derived neurotrophic factor (Bdnf ) (Rocamora et al, 1996), synaptophysin (Ishibashi, 2002), and mRNA of glial glutamate transporters (Genoud et al, 2006). In addition, sensory experience, such as EE, induces expression of the immediate-early genes cAMP responsive element modulator (Crem), Fos, JunB, and early-growth response 1 (Egr1) (Filipkowski et al, 2001;Bisler et al, 2002). However, a genomewide study on genes activated during sensory experience has not been performed yet.…”

Section: Introductionmentioning

confidence: 99%

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Genomewide Analysis of Rat Barrel Cortex Reveals Time- and Layer-Specific mRNA Expression Changes Related to Experience-Dependent Plasticity

Vallès¹,

Boender²,

Gijsbers³

et al. 2011

J. Neurosci.

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Because of its anatomical organization, the rodent whisker-to-barrel system is an ideal model to study experience-dependent plasticity. Manipulation of sensory input causes changes in the properties of the barrels at the physiological, structural, and functional levels. However, much less is known about the molecular events underlying these changes. To explore such molecular events, we have used a genomewide approach to identify key genes and molecular pathways involved in experience-induced plasticity in the barrel cortex of adult rats. Given the natural tendency of rats to explore novel objects, exposure to an enriched environment (EE) was used to stimulate the activity of the whisker-to-barrel cortex in vivo. Microarray analysis at two different time points after EE revealed differential expression of genes encoding transcription factors, including nuclear receptors, as well as of genes involved in the regulation of synaptic plasticity, cell differentiation, metabolism, and, surprisingly, blood vessel morphogenesis. These expression differences reflect changes in somatosensory information processing because unilateral whisker clipping showed EE-induced differential expression patterns in the spared versus deprived barrel cortex. Finally, in situ hybridization revealed cortical layer patterns specific for each selected gene. Together, the present study offers the first genomewide exploration of the key genes regulated by somatosensory stimulation in the barrel cortex and thus provides a solid experimental framework for future in-depth analysis of the mechanisms underlying experience-dependent plasticity.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Genomewide Analysis of Rat Barrel Cortex Reveals Time- and Layer-Specific mRNA Expression Changes Related to Experience-Dependent Plasticity

Vallès¹,

Boender²,

Gijsbers³

et al. 2011

J. Neurosci.

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show abstract

“…To test this, we controlled sensory inputs to different rows in the barrel cortex by trimming all whiskers, except row C, and exposure to an enriched environment for 1 h (ref. 46). Subsequent immunohistochemistry with c-fos antibody revealed increases in the number of c-fospositive cells in the cortical columns corresponding to row C (Fig.…”

Section: Nature Communications | Doi: 101038/ncomms5742mentioning

confidence: 87%

Enhanced synapse remodelling as a common phenotype in mouse models of autism

et al. 2014

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Developmental deficits in neuronal connectivity are considered to be present in patients with autism spectrum disorders (ASDs). Here we examine this possibility by using in vivo spine imaging in the early postnatal cortex of ASD mouse models. Spines are classified by the presence of either the excitatory postsynaptic marker PSD-95 or the inhibitory postsynaptic marker gephyrin. ASD mouse models show consistent upregulation in the dynamics of PSD-95-positive spines, which may subsequently contribute to stable synaptic connectivity. In contrast, spines receiving inputs from the thalamus, detected by the presence of gephyrin clusters, are larger, highly stable and unaffected in ASD mouse models. Importantly, two distinct mouse models, human 15q11-13 duplication and neuroligin-3 R451C point mutation, show highly similar phenotypes in spine dynamics. This selective impairment in dynamics of PSD-95-positive spines receiving intracortical projections may be a core component of early pathological changes and be a potential target of early intervention.

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“…Thus, each cohort consisted of one rat from each of the four conditions, and each cohort finished testing on the same day by staggering the start of habituation. (Gass et al, 1992;Richardson et al, 1992;Bisler et al, 2002;Zangenehpour and Chaudhuri, 2002). The particular time point chosen has allowed distinctions in neuronal activity patterns induced by different radial-arm maze manipulations in previous studies (Maviel et al, 2004).…”

Section: Behavioral Parametersmentioning

confidence: 99%

Qualitatively Different Hippocampal Subfield Engagement Emerges with Mastery of a Spatial Memory Task by Rats

Poirier

Amin²,

Aggleton³

2008

J. Neurosci.

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The parallel, entorhinal cortex projections to different hippocampal regions potentially support separate mnemonic functions. To examine this possibility, rats were trained in a radial-arm maze task so that hippocampal activity could be compared after "early" (two sessions) or "late" (five sessions) learning. Induction of the immediate-early gene Zif268 was then measured, so revealing possible activity differences across hippocampal subfields and the parahippocampal cortices. Each rat in the two experimental groups (early, late) was also yoked to a control rat that obtained the same number of rewards, visited the same number of maze arms, and spent a comparable amount of time in the maze. Although overall Zif268 levels did not distinguish the four groups, significant correlations were found between spatial memory performance and levels of dentate gyrus Zif268 expression in the early but not the late training group. Conversely, hippocampal fields CA3 and CA1 Zif268 expression correlated with performance in the late but not the early training group. This reversal in the correlation pattern was echoed by structural equation modeling, which revealed dynamic changes in effective network connectivity. With early training, the dentate gyrus appeared to help determine CA1 activity, but by late training the dentate gyrus reduced its neural influence. Furthermore, CA1 was distinguished from CA3, each subfield developing opposite relations with task mastery. Thus, functional entorhinal cortex coupling with CA1 activity became more direct with additional training, so producing a trisynaptic circuit bypass. The present study reveals qualitatively different patterns of hippocampal subfield engagement dependent on task demands and mastery.

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Expression of c-Fos, ICER, Krox-24 and JunB in the whisker-to-barrel pathway of rats: time course of induction upon whisker stimulation by tactile exploration of an enriched environment

Cited by 94 publications

References 49 publications

Genomewide Analysis of Rat Barrel Cortex Reveals Time- and Layer-Specific mRNA Expression Changes Related to Experience-Dependent Plasticity

Genomewide Analysis of Rat Barrel Cortex Reveals Time- and Layer-Specific mRNA Expression Changes Related to Experience-Dependent Plasticity

Enhanced synapse remodelling as a common phenotype in mouse models of autism

Qualitatively Different Hippocampal Subfield Engagement Emerges with Mastery of a Spatial Memory Task by Rats

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