Expression of c-Fos, Fos B, Jun B, and Zif268 transcription factor proteins in rat barrel cortex following apomorphine-evoked whisking behavior

Filipkowski, Robert K.; Rydz, Marek; Kaczmarek, Leszek

doi:10.1016/s0306-4522(01)00310-4

Cited by 24 publications

(13 citation statements)

References 69 publications

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“…c-Fos is rapidly and transiently induced in many types of neurons in response to calcium influx caused by depolarization (42). Furthermore, patterns of c-Fos induction recapitulate patterns of neuronal activity in many brain areas, including auditory, visual, and somatosensory cortices (43)(44)(45)(46). For example, deflection of one whisker induces c-Fos in a single barrel representing that whisker in rat somatosensory cortex (45,46).…”

mentioning

confidence: 97%

RETRACTED: Odor maps in the olfactory cortex

Zou

Buck

2005

Proc. Natl. Acad. Sci. U.S.A.

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In the olfactory system, environmental chemicals are deconstructed into neural signals and then reconstructed to form odor perceptions. Much has been learned about odor coding in the olfactory epithelium and bulb, but little is known about how odors are subsequently encoded in the cortex to yield diverse perceptions. Here, we report that the representation of odors by fixed glomeruli in the olfactory bulb is transformed in the cortex into highly distributed and multiplexed odor maps. In the mouse olfactory cortex, individual odorants are represented by subsets of sparsely distributed neurons. Different odorants elicit distinct, but partially overlapping, patterns that are strikingly similar among individuals. With increases in odorant concentration, the representations expand spatially and include additional cortical neurons. Structurally related odorants have highly related representations, suggesting an underlying logic to the mapping of odor identities in the cortex

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mentioning

confidence: 97%

RETRACTED: Odor maps in the olfactory cortex

Zou

Buck

2005

Proc. Natl. Acad. Sci. U.S.A.

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“…Passive whisker stimulation increases brain-derived neurotrophic factor (Bdnf ) (Rocamora et al, 1996), synaptophysin (Ishibashi, 2002), and mRNA of glial glutamate transporters (Genoud et al, 2006). In addition, sensory experience, such as EE, induces expression of the immediate-early genes cAMP responsive element modulator (Crem), Fos, JunB, and early-growth response 1 (Egr1) (Filipkowski et al, 2001;Bisler et al, 2002). However, a genomewide study on genes activated during sensory experience has not been performed yet.…”

Section: Introductionmentioning

confidence: 99%

Genomewide Analysis of Rat Barrel Cortex Reveals Time- and Layer-Specific mRNA Expression Changes Related to Experience-Dependent Plasticity

Vallès¹,

Boender²,

Gijsbers³

et al. 2011

J. Neurosci.

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Because of its anatomical organization, the rodent whisker-to-barrel system is an ideal model to study experience-dependent plasticity. Manipulation of sensory input causes changes in the properties of the barrels at the physiological, structural, and functional levels. However, much less is known about the molecular events underlying these changes. To explore such molecular events, we have used a genomewide approach to identify key genes and molecular pathways involved in experience-induced plasticity in the barrel cortex of adult rats. Given the natural tendency of rats to explore novel objects, exposure to an enriched environment (EE) was used to stimulate the activity of the whisker-to-barrel cortex in vivo. Microarray analysis at two different time points after EE revealed differential expression of genes encoding transcription factors, including nuclear receptors, as well as of genes involved in the regulation of synaptic plasticity, cell differentiation, metabolism, and, surprisingly, blood vessel morphogenesis. These expression differences reflect changes in somatosensory information processing because unilateral whisker clipping showed EE-induced differential expression patterns in the spared versus deprived barrel cortex. Finally, in situ hybridization revealed cortical layer patterns specific for each selected gene. Together, the present study offers the first genomewide exploration of the key genes regulated by somatosensory stimulation in the barrel cortex and thus provides a solid experimental framework for future in-depth analysis of the mechanisms underlying experience-dependent plasticity.

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“…The Barrel cortex contains D 1 receptors and its activation, as shown by an increase in immediate-early gene expression, is dependent on both sensory input from the vibrissae, as well as on dopaminergic receptor activation (Filipkowski et al, 2001;Steiner and Gerfen, 1994;Steiner and Kitai, 2000). The increase in Fos-immunoreactivity is most prominent in the deeper layers (4, 5 and 6) (Filipkowski et al, 2001) and concurs with the increased sniffing/whisking behavior, induced by apomorphine administration as well as by copulatory activities (Figs. 3A and 4A).…”

Section: Barrel Cortexmentioning

confidence: 59%

“…The Barrel cortex is the part of the somatosensory cortex, where the mystacial vibrissae are represented (Filipkowski et al, 2001;Steiner and Kitai, 2000). The Barrel cortex contains D 1 receptors and its activation, as shown by an increase in immediate-early gene expression, is dependent on both sensory input from the vibrissae, as well as on dopaminergic receptor activation (Filipkowski et al, 2001;Steiner and Gerfen, 1994;Steiner and Kitai, 2000).…”

Section: Barrel Cortexmentioning

confidence: 99%

Effects of acute and chronic apomorphine on sex behavior and copulation-induced neural activation in the male rat

Olivier

Jong

Dederen

et al. 2007

European Journal of Pharmacology

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Apomorphine is a non-selective dopaminergic receptor agonist. Because of its pro-erectile effects, apomorphine is clinically used for treatment of erectile dysfunction. We investigated the effects of subcutaneous apomorphine administration (0.4 mg/kg rat) on sexual behavior and matinginduced Fos-expression following acute (day 1) or chronic apomorphine treatment (days 8 and 15) in sexually experienced male rats. Consistent facilitatory effects of apomorphine were observed in the reduced numbers of mounts and intromissions over time and an increased ejaculation frequency on day 1. The first post-ejaculatory interval, however, was lengthened, while other behavioral parameters were unaffected. Fosimmunoreactivity induced by acute apomorphine administration (barrel cortex, paraventricular hypothalamic nucleus, central amygdala and locus coeruleus) was strongly reduced after chronic administration. After mating, induction of Fos-immunoreactivity was observed in well-known areas like medial preoptic nucleus and the posterodorsal medial amygdaloid area. Apomorphine, however, reduced mating-induced Fosimmunoreactivity in the nucleus accumbens shell and prevented its occurrence in its core area. This remarkable apomorphine effect was not observed in any other brain area. We conclude that the behavioral (pro-erectile) effects of apomorphine are consistent over time, and that the diminished accumbens-Fos-immunoreactivity and the elongated post-ejaculatory interval may reflect a decreased response to remote cues from the estrus female.

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Expression of c-Fos, Fos B, Jun B, and Zif268 transcription factor proteins in rat barrel cortex following apomorphine-evoked whisking behavior

Cited by 24 publications

References 69 publications

RETRACTED: Odor maps in the olfactory cortex

RETRACTED: Odor maps in the olfactory cortex

Genomewide Analysis of Rat Barrel Cortex Reveals Time- and Layer-Specific mRNA Expression Changes Related to Experience-Dependent Plasticity

Effects of acute and chronic apomorphine on sex behavior and copulation-induced neural activation in the male rat

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