Expression of bmp2a and bmp2b in late-stage zebrafish median fin development

Crotwell, Patricia L.; Sommervold, Amber R.; Mabee, Paula M.

doi:10.1016/j.modgep.2004.07.001

Cited by 25 publications

(20 citation statements)

References 18 publications

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“…Many of the fin modules that we expected to find are deduced from molecular and developmental data (Ruvinsky and GibsonBrown 2000;Crotwell et al 2001Crotwell et al , 2004Mabee et al 2002;Cloutier 2010;Tanaka and Onimaru 2012), while our analysis focused on variational modules. Variational modules may differ from developmental modules because the combined effect of two or more of the latter on covariance patterns can partially overwrite each other (Hallgrímsson et al 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Lending support to this hypothesis, in the zebrafish, it was found that the dynamic expression patterns of the genes involved during fin formation (e.g., Gdf5,bmp2a,bmp2b) are similar for both the dorsal and anal fins and are associated with the bidirectional radial development patterns observed in both of these fins (Crotwell et al 2001(Crotwell et al , 2004. The integrated development of the endo-and exoskeletal components of the median fins is also thought to be regulated by a developmental module (Mabee et al 2002).…”

Section: Introductionmentioning

confidence: 91%

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Head, Body and Fins: Patterns of Morphological Integration and Modularity in Fishes

2015

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Actinopterygians demonstrate high levels of morphological disparity, especially in the variation of fin positions, sizes and shapes. One hypothesis to explain the diversity of fin morphologies is that it is facilitated by a modular organization. According to this hypothesis, fin modules would be quasi-independent during ontogeny or evolution, facilitating their evolvability. We investigated variational modularity of fins in two cyprinid species, the zebrafish (Danio rerio) and the Northern redbelly dace (Chrosomus eos), to determine which subsets of fins are quasi-independent and which are most highly integrated in positioning. Hypotheses of modularity were evaluated using a combination of methods suitable for analyses of landmarks. The hypothesis that the dorsal and anal fins belong to a posterior trunk and tail module is strongly supported, a finding that can be explained by the use of subcarangiform locomotion in these two species. There is also some support for the hypothesis that the paired fins and head region each constitute variational modules. The support for fin variational modules is weaker than expected considering the wealth of developmental evidence supporting fin modularity. This might be related to a dissociation of the fin positioning modules during actinopterygian evolution, a process that had already been suggested for the dorsal and anal fins. Alternatively, the fin modules inferred from developmental data might not directly translate into variational modules: variational modules can incorporate the signals from numerous partially overlapping developmental processes so that one to one correspondence between developmental and variational modules is not always expected.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

Head, Body and Fins: Patterns of Morphological Integration and Modularity in Fishes

2015

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“…6). The median fins endoskeleton largely consists of repeated elements: the radials in the dorsal and anal fins (segmented into proximal and distal elements), and the hypurals in the caudal fin (Bird and Mabee, 2003;Crotwell et al, 2004). These rod-like elements support the dermal rays and progressively undergo endochondral ossification.…”

Section: Fin Endoskeleton and Expression In Older Larvaementioning

confidence: 99%

Characterization of two new zebrafish members of the hedgehog family: Atypical expression of a zebrafish indian hedgehog gene in skeletal elements of both endochondral and dermal origins

Avaron¹,

Hoffman

Guay³

et al. 2005

Developmental Dynamics

107

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“…In the zebrafish (Danio rerio), a teleost, Crotwell et al (2004) found that Bmp2 is expressed in developing dorsal, anal, and caudal fins. In mammals, expression levels of Bmp2 are affected by androgen and estrogen (Ide et al, 1997;Yamamoto et al, 2002); therefore, we also examined Bmp2 expression levels in fins.…”

Section: Introductionmentioning

confidence: 99%

Expression Levels of Hormone Receptors and Bone Morphogenic Protein in Fins of Medaka

et al. 2009

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In the genus Oryzias, the morphologies of the dorsal and anal fins are typical secondary sex characters. In the Japanese medaka (Oryzias latipes) and Thai medaka (Oryzias minutillus), androgen receptor (AR) expression levels in the dorsal, anal, and pectoral fins were higher in males than in females. Conversely, in both species estrogen receptor (ER) β expression levels in the dorsal and anal fins were higher in females than in males. AR and ERβ expression levels in the dorsal and anal fins of sex-undeterminable individuals of Thai medaka were intermediate between those in normal male and female Thai medaka. There was no difference in the bone morphogenic protein (Bmp) 2b expression level between male and female Japanese medaka. In contrast, the Bmp2b expression level in the dorsal fin of sex-undeterminable individuals was lower than in normal male and female Thai medaka. It is thus clear that androgen and estrogen regulate the sexdependent characters of fin morphology in both Oryzias species. In sex-undeterminable individuals of Thai medaka, the low levels of Bmp2b expression in the dorsal fin are evidence that androgen and estrogen are necessary for adequate expression of Bmp2b in the normal development of at least the dorsal fin.

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Expression of bmp2a and bmp2b in late-stage zebrafish median fin development

Cited by 25 publications

References 18 publications

Head, Body and Fins: Patterns of Morphological Integration and Modularity in Fishes

Head, Body and Fins: Patterns of Morphological Integration and Modularity in Fishes

Characterization of two new zebrafish members of the hedgehog family: Atypical expression of a zebrafish indian hedgehog gene in skeletal elements of both endochondral and dermal origins

Expression Levels of Hormone Receptors and Bone Morphogenic Protein in Fins of Medaka

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